Objective：To analyze data of disabled children of Lianyungang City，to intervene disabled children parents checked in pregnancy healthy birth in nearly five years，and prevent the incidence of sick and disabled children. Methods：The condition of the change in the numbers，regional distribution，sex distribution，and classification of diseases were compared by the data of disabled children after medical identification of Lianyungang City in 2008―2012. Previous basic situation of procreation disabled children was understood by questionnaires issued in disabled children family，intervention effect was analyzed in eugenic guide of the hospital，malformations checking of color doppler imaging ，Tang screening，pregnancy outcome and delivery way. Result：There has no obvious change of 1 046 cases of disabled children according with the standard of the medical identification in nearly five years，the town was more than the countryside，the boys was more than the girls，congenital heart disease ranged the first site in the disease sequence. According to intervention，72 reproduction parents questionnaire of congenital heart disease was normal and 35 reproduction parents of cerebral palsy ranging the second in the disease sequence was also normal .Conclusion：It is obvious that disabled childish parents according to progestational health check perform a series of intervention in preconception care from health education and risk assessment to personal consultant and give birth to all normal children，it cut down the happening of ill-natured pregnancy outcome and disabled childish birth.