Objective：To study the relationship between maternal risk factors and fetus congenital heart disease in Jiangsu province for exploration of effective prevention strategy．Methods：By 1:1.4 case-control study, 373 valid questionnaires were collected from July 2012 to December 2013 and the environmental risk factors of congenital heart disease were analyzed．Results：It showed that the risks such as congenital heart disease family history,history of miscarriage,adverse pregnancy history,history of pesticide exposure during pregnancy,early pregnancy sickness, early pregnancy medication, pregnancy fetal abnormalities,were the most important determinants associated with CHD of children(P<0.05).Conclusions：It is particularly important of maternal health, reducing exposure to risk factors and periodic prenatal for reducing the risk of congenital heart disease.