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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamics. By facilitating cell reprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumour metastasis. Here we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

Keywords： cancer-testis     TH2B     TH2A     H1T     H1.0     H1F0     linker histones    

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Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 2,   Pages 109-109 doi: 10.1007/s11705-009-0258-6

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The 9th China Engineering Management Forum Guangzhou Consensus

Frontiers of Engineering Management 2015, Volume 2, Issue 2,   Pages 105-107 doi: 10.15302/J-FEM-2015019

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Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 491-494 doi: 10.1007/s11684-009-0066-x

Abstract: As a different subset from the Thl and Th2 cells, Th17 cells play an important role in the developmentAs our knowledge on Th17 family members is rapidly growing and changing, it will be important to specifyHerein, we review the key features of Th17 cells and discuss their potential relevance to transplantation

Keywords： TH17 cells     regulation     allograft     rejection    

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2015 International Summit Forum on Engineering Science and Technology Development Strategy, the 205thChina Engineering Science and Technology Forum, and the 9th China Engineering Management Forum Held

China Engineering Management Forum Organization Committee

Frontiers of Engineering Management 2015, Volume 2, Issue 2,   Pages 195-197 doi: 10.15302/J-FEM-2015032

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Special Issue for the 14th Global Chinese Chemical Engineering Symposium

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1321-1322 doi: 10.1007/s11705-023-2351-7

Abstract: Special Issue for the 14th Global Chinese Chemical Engineering Symposium
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Superunderactuated Multifingered Hand for Humanoid Robot

ZHANG Wen-zeng, CHEN Qiang, SUN Zhen-guo, XU Lei

Frontiers of Mechanical Engineering 2006, Volume 1, Issue 1,   Pages 33-39 doi: 10.1007/s11465-005-0015-6

Abstract: A novel superunderactuated multifingered hand (TH-2 Hand) for a humanoid robot was designed based onThe TH-2 Hand was attached to a humanoid robot because of its high personification, superunderactuation

Keywords： control     real-time control     superunderactuation     TH-2     personification    

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Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 461-463 doi: 10.1007/s11705-020-2026-6

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The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 147-152 doi: 10.15302/J-FASE-2016099

Abstract: maintenance of pregnancy and successful embryo development is dependent on the maternal immunomodulation of Th-relatedHowever, investigation of the relationship between P4 and Th immunity in cattle remains incomplete.Therefore, we evaluated plasma P4 concentrations and expressions of three Th-related cytokines, interleukinsIn conclusion, there was no clear relationship between P4 and Th immunity in maternal plasma in the pregnant

Keywords： dairy cow     progesterone     pregnancy     cytokine    

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Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 1,   Pages 3-11 doi: 10.1007/s11465-015-0359-5

Abstract: Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16thand 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa

Keywords： Vitruvius’ De Architectura     Xu Guangqi’s Taixi Shuifa     Jesuit missionaries     Italian Renaissance     drawing     representation    

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Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 1,   Pages 33-43 doi: 10.1007/s11465-016-0373-2

Abstract: second stage, a type of simple roller bearing was used for astronomical instruments not later than the 13thA similar bearing was also applied to an abridged armillary in the 17th century.third stage, the Chinese began studying and using the so-called European-style bearing since the 17th

Keywords： bearing movement     rolling-element bearing     China     early rolling bearings     technology transfer    

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Th17 Cells in autoimmune diseases

Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 10-19 doi: 10.1007/s11684-015-0388-9

Abstract:

Th17 cells are a new subset of CD4+ T cells involved in the clearance of extracellularAccumulating evidence suggests that Th17 cells and their signature cytokines have a pivotal role in theHere, we summarize recent research progress on Th17 function in the development and pathogenesis of autoimmuneWe also propose to identify new small molecule compounds to manipulate Th17 function for potential therapeutic

Keywords： IL-17     Th17 cells     RORγt     autoimmune diseases     posttranslational modification     inhibitors    

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Analysis and Policy Suggestions on Development of Chinese Husbandry Industry during the Period of the 13th

Research Group of Strategic Planning of Chinese Husbandry Development for the 13th Five-Year Plan

Strategic Study of CAE 2016, Volume 18, Issue 1,   Pages 17-21 doi: 10.15302/J-SSCAE-2016.01.003

Abstract:

During the period of the 13th Five-Year Plan and even in a long period in the future, the demand forAiming at the 13th Five-Year Plan, the paper develops the strategic objectives, strategic priorities

Keywords： huasbandry industry     sustainable development     the 13th Five-Year Plan     trend analysis     food safety    

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Dynamic mechanism for the decline of China’s energy intensity during the 11th FYP (Five-Year Plan)

Minghui LI

Frontiers in Energy 2011, Volume 5, Issue 3,   Pages 237-249 doi: 10.1007/s11708-010-0130-x

Abstract: its goal of achieving approximately a 20% reduction in energy intensity during the period of the 11thproperties of the mechanism for the decrease in China’s energy intensity since the beginning of the 11thFirst, compared with the period of the 10th FYP, technical, structural, and residential energy-savingsbefore 2000, technical energy savings have been the main driver of momentum since the beginning of the 11th

Keywords： energy intensity     structural energy savings     technical energy savings    

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Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems None

Santiago RUIZ-ARENAS, Zoltán RUSÁK, Imre HORVÁTH, Ricardo MEJÍ-GUTIERREZ

Frontiers of Information Technology & Electronic Engineering 2019, Volume 20, Issue 2,   Pages 152-175 doi: 10.1631/FITEE.1700277

Abstract:

Malfunction or breakdown of certain mission critical systems (MCSs) may cause losses of life, damage the environments, and/or lead to high costs. Therefore, recognition of emerging failures and preventive maintenance are essential for reliable operation of MCSs. There is a practical approach for identifying and forecasting failures based on the indicators obtained from real life processes. We aim to develop means for performing active failure diagnosis and forecasting based on monitoring statistical changes of generic signal features in the specific operation modes of the system. In this paper, we present a new approach for identifying emerging failures based on their manifestations in system signals. Our approach benefits from the dynamic management of the system operation modes and from simultaneous processing and characterization of multiple heterogeneous signal sources. It improves the reliability of failure diagnosis and forecasting by investigating system performance in various operation modes, includes reasoning about failures and forming of failures using a failure indicator matrix which is composed of statistical deviation of signal characteristics between normal and failed operations, and implements a failure indicator concept that can be used as a plug and play failure diagnosis and failure forecasting feature of cyber-physical systems. We demonstrate that our method can automate failure diagnosis in the MCSs and lend the MCSs to the development of decision support systems for preventive maintenance.

Keywords： Failure indicators     Failure classification     Failure detection and diagnosis     Complex systems    

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Title Author Date Type Operation

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

Preface of special issue of the 10 th International Conference on CO 2 Utilization

Changjun LIU,

Journal Article

The 9th China Engineering Management Forum Guangzhou Consensus

Journal Article

Relationship between Th17 cells and allograft rejection

Zhikun ZHENG MM, Jinsong LI MD, Ke JIANG MD,

Journal Article

2015 International Summit Forum on Engineering Science and Technology Development Strategy, the 205thChina Engineering Science and Technology Forum, and the 9th China Engineering Management Forum Held

China Engineering Management Forum Organization Committee

Journal Article

Special Issue for the 14th Global Chinese Chemical Engineering Symposium

Journal Article

Superunderactuated Multifingered Hand for Humanoid Robot

ZHANG Wen-zeng, CHEN Qiang, SUN Zhen-guo, XU Lei

Journal Article

Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

Journal Article

The relationship between progesterone and Th-related cytokines in plasma during early pregnancy in cows

Lei CHENG,Youdong XIN,Xiaohua LIU,Xiuzhong HU,Min XIANG,Dingfa WANG,Shuhong ZHAO

Journal Article

Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

Journal Article

Rolling-element bearings in China: From ancient times to the 20th century

Lie SUN,Ang LI

Journal Article

Th17 Cells in autoimmune diseases

Lei Han,Jing Yang,Xiuwen Wang,Dan Li,Ling Lv,Bin Li

Journal Article

Analysis and Policy Suggestions on Development of Chinese Husbandry Industry during the Period of the 13th

Research Group of Strategic Planning of Chinese Husbandry Development for the 13th Five-Year Plan

Journal Article

Dynamic mechanism for the decline of China’s energy intensity during the 11th FYP (Five-Year Plan)

Minghui LI

Journal Article

Systematic exploration of signal-based indicators for failure diagnosis in the context of cyber-physical systems

Santiago RUIZ-ARENAS, Zoltán RUSÁK, Imre HORVÁTH, Ricardo MEJÍ-GUTIERREZ

Journal Article