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Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice

Cunjian Yi, Lei Zhang, Fayun Zhang, Li Li, Shengrong Ling, Xiaowen Wang, Xiangqiong Liu, Wei Liang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 101-105 doi: 10.1007/s11684-014-0315-5

Abstract:

This study used different methods to establish an animal model of orthotopic transplantation for ovariancancer to provide an accurate simulation of the mechanism by which tumor occurs and develops in theThis study successfully established an orthotopic transplantation model of ovarian cancer with high ratesThis study also provided a methodological basis for future establishment of an animal model of ovariancancer in humans.

Keywords: ovarian cancer     orthotopic transplantation     animal model    

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract:

A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively

Keywords: ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Frontiers of Medicine   Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancerIn the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors comparedcancer cells in vivo and in vitro.Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poorcancer, which may be a potential prognostic biomarker.

Keywords: ovarian cancer     lncRNA LOC646029     metastasis     microRNA 627-3p     SPRED1    

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 96-100 doi: 10.1007/s11684-014-0316-4

Abstract:

Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer.Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conductedConsequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, whichhas an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary

Keywords: ovarian cancer     para-aortic lymph node     pelvic lymph node    

Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface

Linlin LIANG, Bei XU, Guijin ZHU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 220-226 doi: 10.1007/s11684-009-0037-2

Abstract: This study aimed to evaluate the effect of repeated ovarian stimulation (OS) on the ovarian folliculartotal of 75 mice were enrolled in this experiment and randomly assigned into three groups: repeated ovarianIn the three groups, the single ovarian stimulation treatment significantly increased the mean numberIn conclusion, single ovarian stimulation may produce more oocytes/embryos.cancer.

Keywords: gonadotropin-releasing hormone     ovarian reserve     embryo developmental ability     ovarian surface epithelium    

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 214-222 doi: 10.1007/s11684-017-0518-7

Abstract: cancer has been reached.The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue comparedOverexpression of miR-9 could promote the cell migration and invasion in ovarian cancer, and these processesThus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherinand a novel potential therapeutic approach to control metastasis of ovarian cancer.

Keywords: ovarian cancer     metastasis     miR-9     E-cadherin    

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarianOne hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy.

Keywords: malignant germ cell tumors     ovarian sex cord-stromal tumors     fertility-sparing surgery     prognosis     fertility    

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords: pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug    

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords: epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

Metformin for cancer prevention

Yonghua Yang

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 115-117 doi: 10.1007/s11684-011-0112-3

Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancerand we found that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancerand other types of cancer.

Keywords: orlistat     ferroptosis     FAF2     lung cancer    

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

Keywords: FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Frontiers of Medicine doi: 10.1007/s11684-023-1050-6

Abstract: Pancreatic cancer, notorious for its late diagnosis and aggressive progression, poses a substantial challengeThis review endeavors to furnish a holistic insight into pancreatic cancer, encompassing its epidemiologyand explore recent research advancements in precursor lesions and molecular subtypes of pancreatic cancerAdditionally, we highlight the development and application of multi-omics approaches in pancreatic cancerresearch and discuss the latest combinations of pancreatic cancer biomarkers and their efficacy.

Keywords: pancreatic cancer     cancer screening     single cell     molecular alterations     precancerous lesion     therapy    

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding

Keywords: non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

Title Author Date Type Operation

Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice

Cunjian Yi, Lei Zhang, Fayun Zhang, Li Li, Shengrong Ling, Xiaowen Wang, Xiangqiong Liu, Wei Liang

Journal Article

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Journal Article

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Journal Article

Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface

Linlin LIANG, Bei XU, Guijin ZHU

Journal Article

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Journal Article

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article

Metformin for cancer prevention

Yonghua Yang

Journal Article

Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article