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Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice

Cunjian Yi, Lei Zhang, Fayun Zhang, Li Li, Shengrong Ling, Xiaowen Wang, Xiangqiong Liu, Wei Liang

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 101-105 doi: 10.1007/s11684-014-0315-5

Abstract:

This study used different methods to establish an animal model of orthotopic transplantation for ovariancancer to provide an accurate simulation of the mechanism by which tumor occurs and develops in theThis study successfully established an orthotopic transplantation model of ovarian cancer with high ratesThis study also provided a methodological basis for future establishment of an animal model of ovariancancer in humans.

Keywords： ovarian cancer orthotopic transplantation animal model

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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Frontiers of Medicine 2023, Volume 17, Issue 5, Pages 924-938 doi: 10.1007/s11684-023-1004-z

Abstract: However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancerIn the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors comparedcancer cells in vivo and in vitro.Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poorcancer, which may be a potential prognostic biomarker.

Keywords： ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1

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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract:

A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively

Keywords： ovarian carcinoma prognostic factors surgery chemotherapy survival

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Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 96-100 doi: 10.1007/s11684-014-0316-4

Abstract:

Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer.Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conductedConsequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, whichhas an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary

Keywords： ovarian cancer para-aortic lymph node pelvic lymph node

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Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface

Linlin LIANG, Bei XU, Guijin ZHU

Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 220-226 doi: 10.1007/s11684-009-0037-2

Abstract: This study aimed to evaluate the effect of repeated ovarian stimulation (OS) on the ovarian folliculartotal of 75 mice were enrolled in this experiment and randomly assigned into three groups: repeated ovarianIn the three groups, the single ovarian stimulation treatment significantly increased the mean numberIn conclusion, single ovarian stimulation may produce more oocytes/embryos.cancer.

Keywords： gonadotropin-releasing hormone ovarian reserve embryo developmental ability ovarian surface epithelium

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Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 214-222 doi: 10.1007/s11684-017-0518-7

Abstract: cancer has been reached.The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue comparedOverexpression of miR-9 could promote the cell migration and invasion in ovarian cancer, and these processesThus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherinand a novel potential therapeutic approach to control metastasis of ovarian cancer.

Keywords： ovarian cancer metastasis miR-9 E-cadherin

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Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 509-517 doi: 10.1007/s11684-017-0554-3

Abstract: outcomes of childbearing-age women treated with fertility-sparing surgery (FSS) for non-epithelial ovarianOne hundred and forty eight non-epithelial ovarian tumor women treated with FSS between January 1, 2000Non-epithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy.

Keywords： malignant germ cell tumors ovarian sex cord-stromal tumors fertility-sparing surgery prognosis fertility

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Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Frontiers of Medicine 2024, Volume 18, Issue 3, Pages 430-445 doi: 10.1007/s11684-023-1049-z

Abstract: Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progressionA tumor subpopulation called liver cancer stem cells (CSCs) significantly accounts for the initiation, metastasis, therapeutic resistance, and recurrence of liver cancer.This review sheds light on the bidirectional crosstalk between liver CSCs and immune cells for liver cancerFinally, we discuss the potential application of liver CSCs-targeted immunotherapy for liver cancer treatment

Keywords： liver cancer cancer stem cell immune cell immunotherapy

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords： pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition cancer metastasis cancer stem cell

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Metformin for cancer prevention

Yonghua Yang

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 115-117 doi: 10.1007/s11684-011-0112-3

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancerand we found that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancerand other types of cancer.

Keywords： orlistat ferroptosis FAF2 lung cancer

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

Keywords： FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis

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Low-dose CT for lung cancer screening: opportunities and challenges

Hongbing Shen

Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 116-121 doi: 10.1007/s11684-017-0600-1

Abstract:

Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancerScreening for lung cancer coupled with earlier intervention has long been studied as an approach to mortalityOn the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populationsThis paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancerComplementary biomarkers and technical improvement are expected in the field of lung cancer screening

Keywords： lung cancer low-dose computerized tomography early detection opportunities challenges

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Title Author Date Type Operation

Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice

Cunjian Yi, Lei Zhang, Fayun Zhang, Li Li, Shengrong Ling, Xiaowen Wang, Xiangqiong Liu, Wei Liang

Journal Article

Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

Journal Article

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer

Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He

Journal Article

Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface

Linlin LIANG, Bei XU, Guijin ZHU

Journal Article

Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li

Journal Article

Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely

Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li

Journal Article

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg