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Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1447-x
• The optimum SCR activity was realized by tuning the acid pretreatment.
Keywords: Air pollution control Nitrogen oxides Selective catalytic reduction Red mud Solid waste utilization
The microRNA, miR-29c, participates in muscle development through targeting the
Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI
Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 4, Pages 311-317 doi: 10.15302/J-FASE-2015075
Keywords: pig miR-29c skeletal muscle expression SNP
Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2, Pages 123-138 doi: 10.1007/s11705-022-2194-7
Keywords: NAD(P)H:quinone oxidoreductase 1 cancer therapy target probe nanosystem
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5, Pages 889-901 doi: 10.1007/s11705-020-1919-8
Keywords: gene carriers multitargeting function ECs transfection efficiency
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 290-303 doi: 10.1007/s11684-022-0956-8
Keywords: benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma
Rhizosphere immunity: targeting the underground for sustainable plant health management
Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN
Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 3, Pages 317-328 doi: 10.15302/J-FASE-2020346
Managing plant health is a great challenge for modern food production and is further complicated by the lack of common ground between the many disciplines involved in disease control. Here we present the concept of rhizosphere immunity, in which plant health is considered as an ecosystem level property emerging from networks of interactions between plants, microbiota and the surrounding soil matrix. These interactions can potentially extend the innate plant immune system to a point where the rhizosphere immunity can fulfil all four core functions of a full immune system: pathogen prevention, recognition, response and homeostasis. We suggest that considering plant health from a meta-organism perspective will help in developing multidisciplinary pathogen management strategies that focus on steering the whole plant-microbe-soil networks instead of individual components. This might be achieved by bringing together the latest discoveries in phytopathology, microbiome research, soil science and agronomy to pave the way toward more sustainable and productive agriculture.
Keywords: rhizosphere soil microbiome plant immunity microbial ecology plant health soilborne pathogens
Ruiting Han, Junli Ma, Houkai Li
Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 645-657 doi: 10.1007/s11684-018-0645-9
Keywords: gut microbiota NAFLD obesity insulin resistance bile acids probiotic
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1, Pages 72-80 doi: 10.15302/J-FASE-2016089
Keywords: miR-148b hair follicle proliferation NFAT5 Wnt10b
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1, Pages 220-220 doi: 10.1007/s11705-020-1995-9
Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1, Pages 66-72 doi: 10.15302/J-FASE-2018229
Porcine viral diarrhea is an acute and highly contagious enteric disease of pigs that causes huge economic losses worldwide. Porcine epidemic diarrhea virus (PEDV) and transmissible gastroenteritis virus (TGEV) are the main pathogens responsible for piglet viral diarrhea. However, currently there is no specific drug available for the effective treatment of viral diarrhea. Therefore, it is necessary to seek an effective method to diminish PEDV and TGEV infection rates. RNA interference has been applied successfully to inhibit the virus replication. It provides a potential strategy for breeding resistant pigs. In this study, four promoters and four short hairpin RNA (shRNA) vectors with LoxP sites at each end of the selectable marker genes were constructed to target PEDV and TGEV. These vectors were then transfected into porcine fetal fibroblasts, G418 resistant transfectants were confirmed by PCR and transgenic SCNT porcine blastocysts were obtained. These results have paved the way for future production of marker-free transgenic resistant to PEDV and TEGV pigs by SCNT.
Keywords: piglet diarrhea RNAi PEDV TGEV transgenic resistance breeding
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 449-461 doi: 10.1007/s11684-017-0589-5
In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus, and Zika virus. These viruses can interfere with the specific steps of viral life cycle by blocking the binding between virus and host cells, disrupting viral endocytosis, disturbing membrane fusion, and interrupting viral RNA replication and translation, thereby demonstrating potent therapeutic effect against various emerging and re-emerging viruses. We also discuss some general strategies for developing small-molecule viral inhibitors.
Keywords: emerging and re-emerging viruses small-molecule inhibitor coronavirus Ebola virus Zika virus life cycle
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
Frontiers of Medicine 2008, Volume 2, Issue 1, Pages 19-24 doi: 10.1007/s11684-008-0005-2
Keywords: therapy Sprague administration cardiac hypertrophy valsartan
Gene silencing efficiency of shRNA expression vectors targeting Cx43
Cuihong ZHENG, Yunxia WU, Guangying HUANG, Wei WANG
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 130-135 doi: 10.1007/s11684-009-0030-9
Keywords: RNA interference connexin 43 small hairpin RNA (shRNA) acupuncture
SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping
Frontiers of Medicine 2007, Volume 1, Issue 4, Pages 359-363 doi: 10.1007/s11684-007-0069-4
Keywords: control interruption cytoplasm number growth
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 214-222 doi: 10.1007/s11684-017-0518-7
Keywords: ovarian cancer metastasis miR-9 E-cadherin
Title Author Date Type Operation
Precise regulation of acid pretreatment for red mud SCR catalyst: Targeting on optimizing the acidity
Journal Article
The microRNA, miR-29c, participates in muscle development through targeting the
Weiya ZHANG,Wei WEI,Yuanyuan ZHAO,Shuhong ZHAO,Xinyun LI
Journal Article
Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review
Journal Article
Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
Journal Article
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
Journal Article
Rhizosphere immunity: targeting the underground for sustainable plant health management
Zhong WEI, Ville-Petri FRIMAN, Thomas POMMIER, Stefan GEISEN, Alexandre JOUSSET, Qirong SHEN
Journal Article
Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota
Ruiting Han, Junli Ma, Houkai Li
Journal Article
MicroRNA-148b promotes proliferation of hair follicle cells by targeting
Wanbao YANG,Qinqun LI,Bo SU,Mei YU
Journal Article
Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting
Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng
Journal Article
Construction of multiple shRNA vectors targeting PEDV and TGEV and production of transgenic SCNT porcine
Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG
Journal Article
Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
Journal Article
Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy
ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen
Journal Article
Gene silencing efficiency of shRNA expression vectors targeting Cx43
Cuihong ZHENG, Yunxia WU, Guangying HUANG, Wei WANG
Journal Article
Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell
SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping
Journal Article
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li
Journal Article