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Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 104-113 doi: 10.15302/J-FASE-2014003

Abstract: The cytoplasmic milieu most likely contains all of the specific transcription and/or reprogramming factorsCertain transcription factors in the cytoplast may be critical as has been demonstrated for induced pluripotentThe maternal pronucleus exerts a predominant, transcription-dependent effect on embryo cytofragmentationWith deep analysis of transcriptomics in oocytes and early developmental stage embryos more maternal transcription

Keywords： nuclear reprogramming     somatic cell     transcription factors     transcriptomics    

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediatingRecent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target

Keywords： FOXO3a     FOXM1     transcription factor     cancer     drug resistance     tumorigenesis    

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 412-425 doi: 10.1007/s11684-018-0650-z

Abstract:

Transcription factor networks have evolved in order to control, coordinate, and separate, the functions

Keywords： network     transcription     cancer     MYC     MAX     MLX    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play

Keywords： climacteric fruit ripening / phytohormones / TFs / epigenetic modifications    

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RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Frontiers of Agricultural Science and Engineering   Pages 314-334 doi: 10.15302/J-FASE-2021386

Abstract: Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play

Keywords： climacteric fruit ripening     phytohormones     TFs     epigenetic modifications    

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Characterization of chromatin accessibility in psoriasis

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 483-495 doi: 10.1007/s11684-021-0872-3

Abstract: Our results provided candidate transcription factors and a foundational framework of the regulomes of

Keywords： psoriasis     ATAC-seq     epigenetics     transcription factor    

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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: of tumor suppressor XAF1 gene expression in digestive system cancers, we studied XAF1 gene promoter transcriptionpolymerase chain reaction (PCR) and cloned into pGL3-basic vector and pEGFP-1 vector to assay its promoter transcriptionThe promoter transcription activity was determined by dual-luciferase report assay, and enhanced greenThe dual-luciferase reporter assay showed that the promoter transcription activity in digestive systemremarkably down-regulated XAF1 mRNA expression in digestive system cancer cell lines may be due to loss of transcription

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 295-304 doi: 10.15302/J-FASE-2017159

Abstract: development in the chicken, such as gene polymorphisms, epigenetic modification, noncoding RNAs and transcription

Keywords： chicken     epigenetic modification     miRNAs     skeletal muscle development     SNP     transcription factor    

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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 541-550 doi: 10.1007/s11684-020-0780-y

Abstract: Synthetic lethal screening, which exploits the combination of mutations that result in cell death, is a promising method for identifying novel drug targets. This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc. Here, we revisit current methods used to target c-Myc and discuss the important functional nodes related to c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny but not for normal cells. We further discuss strategies to identify these functional nodes in the context of synthetic lethality. We review the progress and shortcomings of this research field and look forward to opportunities offered by synthetic lethal screening to treat tumors potently.

Keywords： synthetic lethality     undruggable     transcription factor     c-Myc    

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Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 15-26 doi: 10.1007/s11705-017-1629-z

Abstract: Overproduction of small-molecule chemicals using engineered microbial cells has greatly reduced the production cost and promoted environmental protection. Notably, the rapid and sensitive evaluation of the concentrations of the desired products greatly facilitates the optimization process of cell factories. For this purpose, many genetic components have been adapted into biosensors of small molecules, which couple the intracellular concentrations of small molecules to easily detectable readouts such as fluorescence, absorbance, and cell growth. Such biosensors allow a high-throughput screening of the small-molecule products, and can be roughly classified as protein-based and RNA-based biosensors. This review summarizes the recent developments in the design and applications of biosensors for small-molecule products.

Keywords： biosensor     small molecule product     transcription factor     riboswitch     high-throughput screening    

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Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 363-370 doi: 10.1007/s11684-010-0210-7

Abstract: Transcription factors and kinases such as retinoic acid receptor-alpha (RARα), acute myeloid leukemia

Keywords： protein degradation     leukemia     chemical biology     transcription factors     oncoprotein    

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Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 197-203 doi: 10.1007/s11684-009-0036-3

Abstract: The expression of PRL-1 and PRL-3 mRNA was detected by using reverse transcription polymerase chain reaction

Keywords： carcinoma of bladder     phosphatase of regenerating liver 1     phosphatase of regenerating liver 3     reverse transcription    

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SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 81-92 doi: 10.15302/J-FASE-2017180

Abstract:

Sall4 as one of the spalt family members contains several alternative splicing variants, which are differentially expressed and has a key role in maintaining pluripotent stem cells. However, the molecular features and function of SALL4 have not been well elucidated in porcine induced pluripotent stem cells (piPSCs). In this study, we identified splice variants and found two splicing variants through analysis of the porcine transcriptome data derived from piPSCs. SALL4A was only detected in piPSCs but SALL4B was globally expressed in porcine tissues and piPSCs. The level of SALL4B was significantly reduced when piPSCs differentiation occurred, however, the expression of SALL4A was not affected, indicating that SALL4B may be essential for the maintenance of piPSCs self-renewal. Overexpression of SALL4A and SALL4B in PEF cells could significantly stimulated expression of endogenous pluripotent genes, when SALL4B significantly promoted OCT4 expression. Conversely, SALL4A significantly promoted KLF4 expression. Additionally, both SALL4A and SALL4B could repress promoter activity in a dose-dependent manner. Conversely, OTX2 also negatively regulated SALL4 expression. These observations indicate that a negative feedback regulatory mechanism may exist between SALL4 and OTX2, which is useful for the maintenance of the self-renewal of piPSCs.

Keywords： OTX2     pluripotency     pig     SALL4     transcription regulation    

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Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 336-340 doi: 10.1007/s11684-009-0053-2

Abstract: Furthermore, we observed its influence on pro-oncogene by reverse transcription polymerase chain reactionHowever, we observed that repressed transcription at a low concentration.

Keywords： proliferation     c-met     invasion     lanthanum chloride    

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On the principles of Parsimony and Self-consistency for the emergence of intelligence Position Paper

Yi MA, Doris TSAO, Heung-Yeung SHUM

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 9,   Pages 1298-1323 doi: 10.1631/FITEE.2200297

Abstract: Ten years into the revival of and artificial , we propose a theoretical framework that sheds light on understanding within a bigger picture of in general. We introduce two fundamental principles, and , which address two fundamental questions regarding : what to learn and how to learn, respectively. We believe the two principles serve as the cornerstone for the emergence of , artificial or natural. While they have rich classical roots, we argue that they can be stated anew in entirely measurable and computable ways. More specifically, the two principles lead to an effective and efficient computational framework, compressive , which unifies and explains the evolution of modern and most practices of artificial . While we use mainly visual data modeling as an example, we believe the two principles will unify understanding of broad families of autonomous intelligent systems and provide a framework for understanding the brain.

Keywords： Intelligence     Parsimony     Self-consistency     Rate reduction     Deep networks     Closed-loop transcription    

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Title Author Date Type Operation

Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Journal Article

Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Journal Article

The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Journal Article

RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC

Yinglin JI, Mingyang XU, Aide WANG

Journal Article

Characterization of chromatin accessibility in psoriasis

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Journal Article

Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Journal Article

Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Journal Article

Molecular mechanisms of leukemia-associated protein degradation

Ying-Li WU, Guo-Qiang CHEN, Hu-Chen ZHOU,

Journal Article

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

Bin HAO, Changwei LIU, Huixiang LI

Journal Article

SALL4 maintains self-renewal of porcine pluripotent stem cells through downregulation of OTX2

Ning WANG, Sile WANG, Yaxian WANG, Yuanxing CAI, Fan YANG, Huayan WANG

Journal Article

Effect of lanthanum chloride on growth of breast cancer cells and regulation of transcription

Xue LI MM , Ping HE MM , Jie XIA MM , Shiwei SONG BS , Jinhai LU BM , Yunde LIU MM ,

Journal Article

On the principles of Parsimony and Self-consistency for the emergence of intelligence

Yi MA, Doris TSAO, Heung-Yeung SHUM

Journal Article