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Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
Cunjian Yi, Lei Zhang, Fayun Zhang, Li Li, Shengrong Ling, Xiaowen Wang, Xiangqiong Liu, Wei Liang
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 101-105 doi: 10.1007/s11684-014-0315-5
This study used different methods to establish an animal model of orthotopic transplantation for ovariancancer to provide an accurate simulation of the mechanism by which tumor occurs and develops in theThis study successfully established an orthotopic transplantation model of ovarian cancer with high ratesThis study also provided a methodological basis for future establishment of an animal model of ovariancancer in humans.
Keywords: ovarian cancer orthotopic transplantation animal model
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the
Frontiers of Medicine 2023, Volume 17, Issue 5, Pages 924-938 doi: 10.1007/s11684-023-1004-z
Keywords: ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1
Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 91-95 doi: 10.1007/s11684-014-0305-7
A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectively
Keywords: ovarian carcinoma prognostic factors surgery chemotherapy survival
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 96-100 doi: 10.1007/s11684-014-0316-4
Lymph node metastasis has an important effect on prognosis of patients with ovarian cancer.Analysis of the correlation between PAN clearance and prognosis in epithelial ovarian cancer was conductedConsequently, in ovarian carcinoma cytoreductive surgery, resection of the para-aortic lymph node, whichhas an important function in clinical treatment and prognosis of patients with ovarian cancer, is necessary
Keywords: ovarian cancer para-aortic lymph node pelvic lymph node
Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface
Linlin LIANG, Bei XU, Guijin ZHU
Frontiers of Medicine 2009, Volume 3, Issue 2, Pages 220-226 doi: 10.1007/s11684-009-0037-2
Keywords: gonadotropin-releasing hormone ovarian reserve embryo developmental ability ovarian surface epithelium
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 214-222 doi: 10.1007/s11684-017-0518-7
Keywords: ovarian cancer metastasis miR-9 E-cadherin
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 509-517 doi: 10.1007/s11684-017-0554-3
Keywords: malignant germ cell tumors ovarian sex cord-stromal tumors fertility-sparing surgery prognosis fertility
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
Frontiers of Medicine 2024, Volume 18, Issue 3, Pages 430-445 doi: 10.1007/s11684-023-1049-z
Keywords: liver cancer cancer stem cell immune cell immunotherapy
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 942-942 doi: 10.1007/s11684-021-0876-z
Progress and challenges in RET-targeted cancer therapy
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 207-219 doi: 10.1007/s11684-023-0985-y
Keywords: pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Yun Zhang, Robert A. Weinberg
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 361-373 doi: 10.1007/s11684-018-0656-6
Keywords: epithelial-to-mesenchymal transition cancer metastasis cancer stem cell
Metformin for cancer prevention
Yonghua Yang
Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 115-117 doi: 10.1007/s11684-011-0112-3
Orlistat induces ferroptosis-like cell death of lung cancer cells
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 922-932 doi: 10.1007/s11684-020-0804-7
Keywords: orlistat ferroptosis FAF2 lung cancer
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
Fung Zhao, Eric W.-F. Lam
Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 376-380 doi: 10.1007/s11684-012-0228-0
The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.
Keywords: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
Low-dose CT for lung cancer screening: opportunities and challenges
Hongbing Shen
Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 116-121 doi: 10.1007/s11684-017-0600-1
Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancerScreening for lung cancer coupled with earlier intervention has long been studied as an approach to mortalityOn the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populationsThis paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancerComplementary biomarkers and technical improvement are expected in the field of lung cancer screening
Keywords: lung cancer low-dose computerized tomography early detection opportunities challenges
Title Author Date Type Operation
Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice
Cunjian Yi, Lei Zhang, Fayun Zhang, Li Li, Shengrong Ling, Xiaowen Wang, Xiangqiong Liu, Wei Liang
Journal Article
Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the
Journal Article
Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-line
Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie
Journal Article
Clinical significance of para-aortic lymph node dissection and prognosis in ovarian cancer
Xianxian Li, Hui Xing, Lin Li, Yanli Huang, Min Zhou, Qiong Liu, Xiaomin Qin, Min He
Journal Article
Effect of repeated gonadotropin stimulation on ovarian reserves and proliferation of ovarian surface
Linlin LIANG, Bei XU, Guijin ZHU
Journal Article
Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer
Bo Zhou, Hongbin Xu, Meng Xia, Chaoyang Sun, Na Li, Ensong Guo, Lili Guo, Wanying Shan, Hao Lu, Yifan Wu, Yuan Li, Degui Yang, Danhui Weng, Li Meng, Junbo Hu, Ding Ma, Gang Chen, Kezhen Li
Journal Article
Possibility of women treated with fertility-sparing surgery for non-epithelial ovarian tumors to safely
Bin Yang, Yan Yu, Jing Chen, Yan Zhang, Ye Yin, Nan Yu, Ge Chen, Shifei Zhu, Haiyan Huang, Yongqun Yuan, Jihui Ai, Xinyu Wang, Kezhen Li
Journal Article
Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression
Journal Article
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer
Journal Article
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Yun Zhang, Robert A. Weinberg
Journal Article
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
Fung Zhao, Eric W.-F. Lam
Journal Article