[ 1 ] Havelaar AH, Kirk MD, Torgerson PR, Gibb HJ, Hald T, Lake RJ, et al. World Health Organization Global Estimates and Regional Comparisons of the Burden of Foodborne Disease in 2010. PLoS Med 2015;12(12):e1001923. 链接1

[ 2 ] Sun H, Wan Y, Du P, Bai L. The epidemiology of monophasic Salmonella Typhimurium. Foodborne Pathog Dis 2020;17(2):87‒97. 链接1

[ 3 ] Petrovska L, Mather AE, AbuOun M, Branchu P, Harris SR, Connor T, et al. Microevolution of monophasic Salmonella Typhimurium during epidemic, United Kingdom, 2005‒2010. Emerg Infect Dis 2016;22(4):617‒24. 链接1

[ 4 ] FDA. 2019 NARMS Update: Integrated Report Summary [Internet]. Silver Spring: FDA; 2022 Apr 22 [cited 2022 May 1]. Available from: https://www. fda.‍gov/animal-veterinary/national-antimicrobial-resistance-monitoringsystem/2019-narms-update-integrated-report-summary. 链接1

[ 5 ] World Health Organization. Disease Outbreak News; Multicountry outbreak of Salmonella Typhimurium linked to chocolate products- Europe and the United States of America [Internet]. Geneva: World Health Organizatio; 2022 Apr 26 [cited 2022 May 1]. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON369. 链接1

[ 6 ] Laorden L, Herrera-Leo´n S, Marti´nez I, Sanchez A, Kromidas L, Bikandi J, et al. Genetic evolution of the Spanish multidrug-resistant Salmonella enterica 4,5,12:i:- monophasic variant. J Clin Microbiol 2010;48(12):4563‒6. 链接1

[ 7 ] Lucarelli C, Dionisi AM, Filetici E, Owczarek S, Luzzi I, Villa L. Nucleotide sequence of the chromosomal region conferring multidrug resistance (R-type ASSuT) in Salmonella Typhimurium and monophasic Salmonella Typhimurium strains. J Antimicrob Chemother 2012;67(1):111‒4. 链接1

[ 8 ] Boland C, Bertrand S, Mattheus W, Dierick K, Jasson V, Rosseel T, et al. Extensive genetic variability linked to IS26 insertions in the fljB promoter region of atypical monophasic variants of Salmonella enterica serovar Typhimurium. Appl Environ Microbiol 2015;81(9):3169‒75. 链接1

[ 9 ] Ingle DJ, Ambrose RL, Baines SL, Duchene S, Gonçalves da Silva A, Lee DYJ, et al. Evolutionary dynamics of multidrug resistant Salmonella enterica serovar 4, [5],12:i:- in Australia. Nat Commun 2021;12:4786. 链接1

[10] Van Puyvelde S, Pickard D, Vandelannoote K, Heinz E, Barbé B, de Block T, et al. An African Salmonella Typhimurium ST313 sublineage with extensive drugresistance and signatures of host adaptation. Nat Commun 2019;10:4280. 链接1

[11] Van Boeckel TP, Pires J, Silvester R, Zhao C, Song J, Criscuolo NG, et al. Global trends in antimicrobial resistance in animals in low- and middle-income countries. Science 2019;365(6459):eaaw1944. 链接1

[12] Kuehn B. Multidrug-resistant Salmonella. JAMA 2019;322(14):1344. 链接1

[13] Zeng X, Lv S, Qu C, Lan L, Tan D, Li X, et al. Serotypes, antibiotic resistance, and molecular characterization of non-typhoidal Salmonella isolated from diarrheic patients in Guangxi Zhuang Autonomous Region, China, 2014‒2017. Food Control 2021;120:107478. 链接1

[14] He J, Sun F, Sun D, Wang Z, Jin S, Pan Z, et al. Multidrug resistance and prevalence of quinolone resistance genes of Salmonella enterica serotypes 4,[5],12:i:- in China. Int J Food Microbiol 2020;330:108692. 链接1

[15] Xie X, Wang Z, Zhang K, Li Y, Hu Y, Pan Z, et al. Pig as a reservoir of CRISPR type TST4 Salmonella enterica serovar Typhimurium monophasic variant during 2009‒2017 in China. Emerg Microbes Infect 2020;9(1):1‒4. 链接1

[16] Jiang Z, Anwar TM, Peng X, Biswas S, Elbediwi M, Li Y, et al. Prevalence and antimicrobial resistance of Salmonella recovered from pig-borne food products in Henan. China Food Control 2021;121:107535. 链接1

[17] Zheng D, Ma K, Du J, Zhou Y, Wu G, Qiao X, et al. Characterization of human origin Salmonella serovar 1,4,[5],12:i:‍-in eastern China, 2014 to 2018. Foodborne Pathog Dis 2021;18(11):790‒7. 链接1

[18] Liu JK, Bai L, Li WW, Han HH, Fu P, Ma XC, et al. Trends of foodborne diseases in China: lessons from laboratory-based surveillance since 2011. Front Med 2018;12(1):48‒57. 链接1

[19] Xia S, Hendriksen RS, Xie Z, Huang L, Zhang J, Guo W, et al. Molecular characterization and antimicrobial susceptibility of Salmonella isolates from infections in humans in Henan Province. China J Clin Microbiol 2009;47(2):401‒9. 链接1

[20] Nucera DM, Maddox CW, Hoien-Dalen P, Weigel RM. Comparison of API 20E and invA PCR for identification of Salmonella enterica isolates from swine production units. J Clin Microbiol 2006;44(9):3388‒90. 链接1

[21] Prendergast DM, Hand D, Ghallchóir EN, McCabe E, Fanning S, Griffin M, et al. A multiplex real-time PCR assay for the identification and differentiation of Salmonella enterica serovar Typhimurium and monophasic serovar 4,[5],12:-. Int J Food Microbiol 2013;166(1):48‒53. 链接1

[22] CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 28th ed. CLSI supplement M100. CLSI, Wayne, PA, USA. 2018.

[23] The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0, 2020 [Internet]. Växjö: The European Committee on Antimicrobial Susceptibility Testing; 2022 Apr 21 [cited 2022May 1]. Available from: http://www.eucast.org. 链接1

[24] Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol 2012;19(5):455‒77. 链接1

[25] Wick RR, Judd LM, Gorrie CL, Holt KE, Phillippy AM. Unicycler: resolving bacterial genome assemblies from short and long sequencing reads. PLoS Comput Biol 2017;13(6):e1005595. 链接1

[26] Li R, Chen K, Chan EWC, Chen S. Resolution of dynamic MDR structures among the plasmidome of Salmonella using MinION single-molecule, long-read sequencing. J Antimicrob Chemother 2018;73(10):2691‒5. 链接1

[27] Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinformatics 2014;30(14):2068‒9. 链接1

[28] Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V, et al. ResFinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother 2020;75(12):3491‒500. 链接1

[29] Kichenaradja P, Siguier P, Perochon J, Chandler M. ISbrowser: an extension of ISfinder for visualizing insertion sequences in prokaryotic genomes. Nucleic Acids Res 2010;38(Database issue):D62‒8. 链接1

[30] Carattoli A, Zankari E, García-Fernández A, Voldby Larsen M, Lund O, Villa L, et al. In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing. Antimicrob Agents Chemother 2014;58(7):3895‒903. 链接1

[31] Liu B, Zheng D, Jin Q, Chen L, Yang J. VFDB 2019: a comparative pathogenomic platform with an interactive web interface. Nucleic Acids Res 2019;47(D1): D687‒92. 链接1

[32] Li H, Handsaker B, Wysoker A, Fennell T, Ruan J, Homer N, et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 2009;25(16):2078‒9. 链接1

[33] Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods 2012;9(4):357‒U54. 链接1

[34] Elbediwi M, Wu B, Pan H, Jiang Z, Biswas S, Li Y, et al. Genomic characterization of mcr-1-carrying Salmonella enterica serovar 4,[5],12:i:- ST34 clone isolated from pigs in China. Front Bioeng Biotechnol 2020;8:663. 链接1

[35] Price MN, Dehal PS, Arkin AP, Poon AF. FastTree 2—approximately maximumlikelihood trees for large alignments. PLoS ONE 2010;5(3):e9490. 链接1

[36] Letunic I, Bork P. Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees. Nucleic Acids Res 2016;44(W1):W242‒5. 链接1

[37] Drummond AJ, Rambaut A. BEAST: Bayesian evolutionary analysis by sampling trees. BMC Evol Biol 2007;7(1):1‒8. 链接1

[38] Yoshida CE, Kruczkiewicz P, Laing CR, Lingohr EJ, Gannon VP, Nash JH, et al. The Salmonella In Silico Typing Resource (SISTR): an open web-accessible tool for rapidly typing and subtyping draft Salmonella genome assemblies. PLoS ONE 2016;11(1):e0147101. 链接1

[39] Garcia P, Malorny B, Rodicio MR, Stephan R, Hachler H, Guerra B, et al. Horizontal acquisition of a multidrug-resistance module (R-type ASSuT) is responsible for the monophasic phenotype in a widespread clone of Salmonella serovar 4,[5],12:i:-. Front Microbiol 2016;7:680. 链接1

[40] Fang LX, Li XP, Deng GH, Li SM, Yang RS, Wu ZW, et al. High genetic plasticity in multidrug-resistant sequence type 3-IncHI2 plasmids revealed by sequence comparison and phylogenetic analysis. Antimicrob Agents Chemother 2018;62(4):e02068-17. 链接1

[41] Li R, Lu X, Peng K, Liu Y, Xiao X, Wang Z. Reorganization of mcr-1-bearing large MDR plasmids resolved by nanopore sequencing. J Antimicrob Chemother 2020;75(6):1645‒7. 链接1

[42] Guo Q, Ding B, Jové T, Stoesser N, Cooper VS, Wang M, et al. Characterization of a novel IncHI2 plasmid carrying tandem copies of blaCTX-M-2 in a fosA6- harboring Escherichia coli sequence type 410 strain. Antimicrob Agents Chemother 2016;60(11):6742‒7. 链接1

[43] Elnekave E, Hong S, Mather AE, Boxrud D, Taylor AJ, Lappi V, et al. Salmonella enterica serotype 4,[5],12:i:- in swine in the United States Midwest: an emerging multidrug-resistant clade. Clin Infect Dis 2018;66(6):877‒85. 链接1

[44] Patchanee P, Tanamai P, Tadee P, Hitchings MD, Calland JK, Sheppard SK, et al. Whole-genome characterisation of multidrug resistant monophasic variants of Salmonella Typhimurium from pig production in Thailand. PeerJ 2020;8:e9700. 链接1

[45] Elnekave E, Hong SL, Lim S, Boxrud D, Rovira A, Mather AE, et al. Transmission of multidrug-resistant Salmonella enterica subspecies enterica 4,[5],12:i:- sequence type 34 between Europe and the United States. Emerg Infect Dis 2020;26(12):3034‒8. 链接1

[46] Mather AE, Phuong TLT, Gao Y, Clare S, Mukhopadhyay S, Goulding DA, et al. New variant of multidrug-resistant Salmonella enterica serovar Typhimurium associated with invasive disease in immunocompromised patients in Vietnam. mBio 2018;9(5):e01056-18. 链接1

[47] Diaconu EL, Alba P, Feltrin F, Di Matteo P, Iurescia M, Chelli E, et al. Emergence of IncHI2 plasmids with mobilized colistin resistance (mcr)-9 gene in ESBLproducing, multidrug-resistant Salmonella Typhimurium and its monophasic variant ST34 from food-producing animals in Italy. Front Microbiol 2021;12:705230. 链接1

[48] Macesic N, Blakeway LV, Stewart JD, Hawkey J, Wyres KL, Judd LM, et al. Silent spread of mobile colistin resistance gene mcr-9.1 on IncHI2 ‘superplasmids’ in clinical carbapenem-resistant Enterobacterales. Clin Microbiol Infect 2021;27(12). 1856.e7-13. 链接1

[49] Li L, Liao XP, Liu ZZ, Huang T, Li X, Sun J, et al. Co-spread of oqxAB and blaCTX-M-9G in non-typhi Salmonella enterica isolates mediated by ST2-IncHI2 plasmids. Int J Antimicrob Agents 2014;44(3):263‒8. 链接1

[50] Garcia-Fernandez A, Carattoli A. Plasmid double locus sequence typing for IncHI2 plasmids, a subtyping scheme for the characterization of IncHI2 plasmids carrying extended-spectrum beta-lactamase and quinolone resistance genes. J Antimicrob Chemother 2010;65(6):1155‒61. 链接1

[51] Billman-Jacobe H, Liu Y, Haites R, Weaver T, Robinson L, Marenda M, et al. pSTM6-275, a conjugative IncHI2 plasmid of Salmonella enterica that confers antibiotic and heavy-metal resistance under changing physiological conditions. Antimicrob Agents Chemother 2018;62(5):e02357‒17. 链接1

[52] Branchu P, Charity OJ, Bawn M, Thilliez G, Dallman TJ, Petrovska L, et al. SGI-4 in monophasic Salmonella Typhimurium ST34 is a novel ICE that enhances resistance to copper. Front Microbiol 2019;10:1118. 链接1

[53] Bearson BL, Trachsel JM, Shippy DC, Sivasankaran SK, Kerr BJ, Loving CL, et al. The role of Salmonella genomic Island 4 in metal tolerance of Salmonella enterica serovar I 4,[5],12:i:- pork outbreak isolate USDA15WA-1. Genes 2020;11(11):1291. 链接1

[54] Arnott A, Wang Q, Bachmann N, Sadsad R, Biswas C, Sotomayor C, et al. Multidrug-resistant Salmonella enterica 4,[5],12:i:- sequence type 34, New South Wales, Australia, 2016‒2017. Emerg Infect Dis 2018;24(4):751‒3. 链接1