The application of bio-entropy in evaluation of natural medicine: Drugs, particularly natural medicines, can act on one or multiple targets, amplifying the body's self-organization, defense, self-healing, ware resistance, and adaptability. This process reverses disease-induced entropy increase, thus aiding recovery. By integrating physiological signal entropy with large-scale AI model analysis to predict overall biological entropy, drug discovery can be optimized across target selection, composition refinement, determination of formula and delivery route, and clinical trial design, leading to the development of safer, more cost-effective, and compliant drugs.