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产品设计；知识推送系统；增强训练集；多分类神经网络；知识匹配 1

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Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

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《医学前沿（英文）》 2015年 第9卷 第1期   页码 46-56 doi: 10.1007/s11684-015-0375-1

摘要：

Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.

关键词： oxidative stress     Nrf2     triterpenoids     sickle cell disease     vaso-occlusion     CDDO-Me    

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Effects of ancillary ligands in acceptorless benzyl alcohol dehydrogenation mediated by phosphine-free cobalt complexes

《化学科学与工程前沿（英文）》 2023年 第17卷 第3期   页码 314-325 doi: 10.1007/s11705-022-2219-2

摘要： Acceptorless alcohol dehydrogenation stands out as one of the most promising strategies in hydrogen storage technologies. Among various catalytic systems for this reaction, cost-effective molecular catalysts using phosphine-free ligands have gained considerable attention. However, the central challenge for using non-precious metals is to overcome the propensity of reacting by one-electron pathway. Herein, we synthesized a phosphine-free η5-C5Me5-Co complex by using the metal–ligand cooperative strategy and compared its activity with analogous catalysts toward acceptorless alcohol dehydrogenation. The catalyst showed excellent performance with a turnover number of 130.4 and a selectivity close to 100%. The improved performance among the class of η5-C5Me5-Co complexes could be attributed to the more accessible Co center and its cooperation with the redox-active ligand. To further study the systematic structure-activity relationship, we investigated the electronic structures of η5-C5Me5-Co complexes by a set of characterizations. The results showed that the redox-active ligand has a significant influence on the η5-C5Me5-Co moiety. In the meantime, the proximal O−/OH group is beneficial for shuttling protons. For the catalytic cycle, two dehydrogenation scenarios were interrogated through density functional theory, and the result suggested that the outer-sphere pathway was preferred. The formation of a dihydrogen complex was the rate-determining step with a ΔG value of 16.9 kcal∙mol‒1. The electron population demonstrated that the η5-C5Me5 ligand played a key role in stabilizing transition states during dehydrogenation steps. This work identified the roles of vital ligand components to boost catalytic performance and offered rationales for designing metal–ligand cooperative nonprecious metal complexes.

关键词： acceptorless alcohol dehydrogenation     η5-C5Me5-Co     metal–ligand cooperation     theoretical calculation    

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第四届设计、机械和材料工程国际会议(D2ME 2019)

会议日期： 2019年09月26日

会议地点： 釜山，韩国

主办单位： HKSME

第四届设计、机械和材料工程国际会议(D2ME 2019)

会议日期： 2019年09月26日

会议地点： 釜山，韩国

主办单位： HKSME

知识推送系统中一种基于多分类径向基神经网络的知识匹配方法 Research Articles

张树有,顾叶,伊国栋,王自立

《信息与电子工程前沿（英文）》 2020年 第21卷 第7期   页码 963-1118 doi: 10.1631/FITEE.1900057

摘要： 聚焦知识匹配领域，开展提高产品设计中知识推送系统性能的探索性研究。传统匹配算法需重复计算，导致响应时间长，准确性也有待提高。本文目标是实现对设计者知识需求的快速响应，并提供优质知识推送服务。在改进之前工作基础上，研究实际操作中增强有限训练集的两种方法：案例特征向量中振荡特征权值和修正案例特征。此外，提出一种多分类径向基神经网络，可从知识库中一次性匹配知识并保证推送结果准确性。使用数控机床中导轨设计的训练集训练和测试该方法，实验结果表明增强训练集有效，本文提出的方法优于其他匹配方法。

关键词： 产品设计；知识推送系统；增强训练集；多分类神经网络；知识匹配    

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标题 作者 时间 类型 操作

Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review

null

期刊论文

Effects of ancillary ligands in acceptorless benzyl alcohol dehydrogenation mediated by phosphine-free cobalt complexes

期刊论文

第四届设计、机械和材料工程国际会议(D2ME 2019)

2019年09月26日

会议信息

第四届设计、机械和材料工程国际会议(D2ME 2019)

2019年09月26日

会议信息

知识推送系统中一种基于多分类径向基神经网络的知识匹配方法

张树有,顾叶,伊国栋,王自立

期刊论文