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《医学前沿(英文)》 2023年 第17卷 第3期 页码 476-492 doi: 10.1007/s11684-022-0966-6
关键词: EIF4A1 G-quadruplex hepatocellular carcinoma tRNA-derived small RNA translation initiation
《医学前沿(英文)》 页码 805-822 doi: 10.1007/s11684-023-1025-7
关键词: CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic strategies
《化学科学与工程前沿(英文)》 2022年 第16卷 第7期 页码 1090-1100 doi: 10.1007/s11705-021-2091-5
关键词: synthesis pyrimidin-4-amine derivatives 1 2 4-oxadiazole insecticidal activity structure-activity relationship
用以产生高纯度涡旋波束的宽带圆极化透射阵 Correspondence
邱靓婕1,2,3,4,李秀萍1,2,3,4,齐紫航1,2,3,4,赵文禹1,2,3,4,黄雨菡5
《信息与电子工程前沿(英文)》 2023年 第24卷 第6期 页码 927-934 doi: 10.1631/FITEE.2200539
Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO
《化学科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 186-191 doi: 10.1007/s11705-009-0004-0
关键词: microwave-assisted synthesis naphthyl thiazolidin-4-one antimicrobial
新闻媒体眼中的中国:新冠肺炎疫情下的案例研究 Research Article
黄宏1,2,3,4,陈哲学1,2,3,4,石宣化1,2,3,4,王晨旭1,2,3,4,何泽鹏1,2,3,4,金海1,2,3,4,张明新5,李宗亚5
《信息与电子工程前沿(英文)》 2021年 第22卷 第11期 页码 1443-1457 doi: 10.1631/FITEE.2000689
4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine
Hui QIU, Hui ZHANG, Zuohua FENG
《医学前沿(英文)》 2009年 第3卷 第1期 页码 20-25 doi: 10.1007/s11684-009-0006-9
关键词: 4-1BB ligand tumor immunotherapy tumor microenvironment
基于半导体纳米晶体的神经突触器件 Review
步明轩1,2,王越1,2,尹蕾1,2,童周禹1,2,张懿强3,杨德仁1,2,4,5,皮孝东1,2,4,5
《信息与电子工程前沿(英文)》 2022年 第23卷 第11期 页码 1579-1601 doi: 10.1631/FITEE.2100551
近年来,人们对信息处理的需求日益增长,脑启发式神经形态器件得到了广泛的关注。突触器件作为一类重要的神经形态器件,在短短几年内迅速升温。在用于制备突触器件的各种材料中,半导体纳米晶体(NCs)因其优异的电学和光学性能而成为首选材料之一。本综述论文首先介绍了基于半导体纳米晶体的突触器件的研究背景及半导体纳米晶体的基本性质。然后,根据器件有源层所用纳米晶体种类的不同,分类介绍了基于纳米晶体的突触器件的最新研究进展。最后,讨论了基于半导体纳米晶体的突触器件目前仍面临的问题和挑战。
关键词: 半导体纳米晶体;突触器件;神经形态计算
基于二硫化钛可饱和吸收体的被动锁模掺铒光纤激光器 Research Articles
尚新新1,3,4,郭林广1,3,4,张华年2,李登旺1,3,4,岳庆炀1,3,4
《信息与电子工程前沿(英文)》 2021年 第22卷 第5期 页码 615-766 doi: 10.1631/FITEE.2000341
空间衍射望远系统发展现状 Review Article
赵维1,3,4,王新1,刘华‡2,4,陆子凤2,4,卢振武5
《信息与电子工程前沿(英文)》 2020年 第21卷 第6期 页码 809-962 doi: 10.1631/FITEE.1900529
关键词: 薄膜衍射光学元件;衍射望远系统;超大口径
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化 Article
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
《工程(英文)》 2024年 第32卷 第1期 页码 58-69 doi: 10.1016/j.eng.2023.09.019
Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liver, creating a regulatory transcriptional loop. The Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase genes. Our in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studied in this work confirms a significant enrichment of these transcription factors specifically in the liver. Our previous studies identified HNF1A as a master regulator of fucosylation, glycan branching, and galactosylation of plasma glycoproteins. Here, we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan phenotype. We used the state-of-the-art clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A, HNF4A, and FOXA2 genes in HepG2 cells—a human liver cancer cell line. The results show that the downregulation of all three genes individually and in pairs affects the transcriptional activity of many glyco-genes, although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan structures. The effect is better seen as an overall change in the total HepG2 N-glycome, primarily due to the extension of biantennary glycans. We propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan structure. We also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.
关键词: Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) Epigenetics Hepatocyte nuclear factor 1 alpha (HNF1A) Hepatocyte nuclear factor 4 alpha (HNF4A) Forkhead box protein A2 (FOXA2) N-glycosylation HepG2 cells
Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE
《化学科学与工程前沿(英文)》 2009年 第3卷 第3期 页码 305-309 doi: 10.1007/s11705-009-0021-z
利用CES1和DPP-IV的组织残余活性准确评估和追踪特异性肝损伤过程 Article
潘秋莎, 宋培放, 倪振华, 钱星凯, 王安琪, 邹立伟, 刘勇, 王平, 张卫东, 马红, 杨凌
《工程(英文)》 2022年 第19卷 第12期 页码 153-165 doi: 10.1016/j.eng.2021.09.014
《环境科学与工程前沿(英文)》 2023年 第17卷 第3期 doi: 10.1007/s11783-023-1631-2
● All 1,4-naphthoquinone hybrids exhibited significant antimicrobial activity.
关键词: 1 4-naphthoquinone derivatives Antibacterial Action mechanism RecA
《环境科学与工程前沿(英文)》 2021年 第15卷 第5期 doi: 10.1007/s11783-020-1341-y
• 1,4-Dioxane was degraded via the photo-Fenton reactive membrane filtration.
标题 作者 时间 类型 操作
carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I
期刊论文
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms
期刊论文
Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4
期刊论文
Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones
Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO
期刊论文
新闻媒体眼中的中国:新冠肺炎疫情下的案例研究
黄宏1,2,3,4,陈哲学1,2,3,4,石宣化1,2,3,4,王晨旭1,2,3,4,何泽鹏1,2,3,4,金海1,2,3,4,张明新5,李宗亚5
期刊论文
4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine
Hui QIU, Hui ZHANG, Zuohua FENG
期刊论文
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
期刊论文
Design, synthesis, and antiviral properties of 2-aryl-1H-benzimidazole-4-carboxamide derivatives
Xianjin LUO, Zhonglü ZHANG, Yutian YANG, Fei XUE, Naiyun XIU, Yuanbin SHE
期刊论文
Evaluation of 1,4-naphthoquinone derivatives as antibacterial agents: activity and mechanistic studies
期刊论文