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Antimicrobial use in food animal production: situation analysis and contributing factors
Ziping WU
《农业科学与工程前沿(英文)》 2018年 第5卷 第3期 页码 301-311 doi: 10.15302/J-FASE-2018207
By measuring the quantity and ways in which antimicrobials are used, and reviewing different technical and socioeconomic factors influencing antimicrobial use at farm level, this study discusses the main knowledge gaps in antimicrobial use in food animal production and provides recommendations for future research and policy development. The review reveals that antimicrobial use in food animals exhibit strong regional and species differences, and there are still large information gaps concerning the current state of antimicrobial use. Factors associated with animal health (including antimicrobial resistance), animal health improvement, economic costs and benefits relevant to animal diseases, and potential technological alternatives or alternative systems all have an impact on antimicrobial use on the farm. There is a clear need to resolve the data gap by monitoring antimicrobial use and developing an analytical framework to better understand farmer behaviors under different technical, economic and environmental circumstances.
关键词: antimicrobial use drivers for antimicrobial use food animal production
Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 2101-2113 doi: 10.1007/s11705-023-2361-5
关键词: ursolic acid antibacterial activities reactive oxygen species apoptosis
Li SHENG,Shuhang HUANG,Minghao SUI,Lingdian ZHANG,Lei SHE,Yong CHEN
《环境科学与工程前沿(英文)》 2015年 第9卷 第4期 页码 625-633 doi: 10.1007/s11783-014-0711-8
关键词: multiwalled carbon nanotubes copper nanoparticles antimicrobial activity Escherichia coli (E. coil)
Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO
《化学科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 186-191 doi: 10.1007/s11705-009-0004-0
关键词: microwave-assisted synthesis naphthyl thiazolidin-4-one antimicrobial
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 517-521 doi: 10.1007/s11684-016-0480-9
This study aimed to compare the antimicrobial activities of topical agents against Propionibacterium acnes isolated from patients admitted to a hospital in Shanghai, China. The minimal inhibitory concentrations of the cultured P. acnes were determined in accordance with the Clinical and Laboratory Standards Institute. Susceptibilities to clindamycin and erythromycin were compared in terms of gender, age, disease duration, previous treatment, and disease severity. A total of 69 P. acnes strains were isolated from 98 patients (70.41%). The susceptibility to triple antibiotic ointment (neomycin/bacitracin/polymyxin B) and bacitracin was 100%. The susceptibility to fusidic acid was 92.7%. The resistance rates to neomycin sulfate, erythromycin, and clindamycin were 11.7%, 49.3%, and 33.4%, respectively. The high resistance rate to clindamycin and erythromycin was significantly affected by gender, previous treatment, and disease severity rather than by age and disease duration. Topical antibiotics should not be used separately for long-term therapy to avoid multiresistance. The use of topical antibiotics should be determined by clinicians on the basis of clinical conditions.
关键词: antimicrobial susceptibility/resistance Propionibacterium acnes topical antibiotics in vitro study
越南广平和顺化两省猪场分离副猪嗜血杆菌的抗生素耐药表型和耐药基因之间的相关性研究 Article
Chao Nguyen Van, 张丽君, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, 黄琦, 周锐
《工程(英文)》 2020年 第6卷 第1期 页码 40-48 doi: 10.1016/j.eng.2019.10.014
副猪嗜血杆菌是一种对全球养猪业造成重大经济损失的病原菌。副猪嗜血杆菌防控失败的原因之一是细菌耐药性不断加重。越南拥有亚洲排名第二的生猪产量,但是缺乏针对副猪嗜血杆菌耐药性的相关研究和数据。本研究的目的是调查越南副猪嗜血杆菌的耐药性,并分析耐药性和耐药性基因之间的关系。本研究所使用的副猪嗜血杆菌分离菌株来自我们之前研究中从越南广平省和顺化省猪场分离到的菌株。本研究分别利用肉汤微稀释法和聚合酶链反应(PCR)法检测了这些菌株对25种抗生素的耐药性及相关耐药基因的存在情况。结果显示,这些分离株对甲氧苄啶/磺胺甲恶唑的耐药率达高到94.6%,其次是黏菌素、氯霉素、庆大霉素、青霉素、林可霉素和阿莫西林。这些菌株中相关联耐药基因的检出率分别为blaTEM-1 94.6%、int 76.8%、gyrA 58.9%以及rmtD 50.0%。头孢呋辛、氯霉素和妥布霉素的耐药性表型分别与耐药基因blaROB-1 [优势比(OR) = 26.3, 95% 置信区间(CI)2.7~255.7, p = 0.002]、catl (OR = 25.1, 95% CI 2.4~258.9, p = 0.004)以及strB (OR = 23.5, 95% CI 2.6~212.6, p = 0.001)呈显著正相关。本研究首次揭示了越南中部地区副猪嗜血杆菌的耐药性情况,有助于该疾病的临床控制,能够为降低越南中部的养猪业中该菌的耐药性以及为相关政策制定和临床用药提供指导。
关键词: 副猪嗜血杆菌,抗药性,耐药基因,越南
吖啶– 核定位序列偶联构建的高活性抗菌肽 Artical
Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang
《工程(英文)》 2015年 第1卷 第4期 页码 500-505 doi: 10.15302/J-ENG-2015106
多重耐药菌的出现迫切需要发现具有新作用机制的抗生素。在本研究中,笔者将疏水的吖啶分子连接到核定位序列 (NLS) 的N末端合成了一种新型的抗菌药物Acr3-NLS。为了进 一步提高该试剂的抗菌活性,笔者将两个单体Acr3-NLS分子通过二硫键连接合成了二聚体(Acr3-NLS)2。结果显示,与NLS相比,Acr3-NLS,特别是(Acr3-NLS)2,对革兰阴性菌和革兰阳性菌表现出显著的抗菌活性。随后,其作用机制的研究表明,Acr3-NLS 和(Acr3-NLS)2 可通过细胞膜破坏方式和DNA 结合方式杀死细菌。作用于细胞膜和细胞内DNA的双靶点抑杀机制可以降低细菌对Acr3-NLS 和(Acr3-NLS)2 产生耐药性的风险。总之, 本研究提供了一种新的策略,可用于设计具有双重作用机制的高效抗菌药物。
细菌耐药性威胁人类健康 Editorial
沈建忠, Timothy R. Walsh
《工程(英文)》 2022年 第15卷 第8期 页码 1-2 doi: 10.1016/j.eng.2022.06.003
Strategies on designing multifunctional surfaces to prevent biofilm formation? ?
Yang Lu,Zhanguo Yue,Wei Wang,Zhiqiang Cao
《化学科学与工程前沿(英文)》 2015年 第9卷 第3期 页码 324-335 doi: 10.1007/s11705-015-1529-z
Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition
Ana Mora-Boza, Francisco J. Aparicio, María Alcaire, Carmen López-Santos, Juan P. Espinós, Daniel Torres-Lagares, Ana Borrás, Angel Barranco
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 330-339 doi: 10.1007/s11705-019-1803-6
关键词: plasma polymers conformal plasma deposition chlorhexidine bactericide PDMS biocompatibility
微生物耐药性在人与动物间的传播——我们为什么需要知道更多? Views & Comments
Julian Parkhill
《工程(英文)》 2022年 第15卷 第8期 页码 11-12 doi: 10.1016/j.eng.2022.04.007
《农业科学与工程前沿(英文)》 2021年 第8卷 第4期 页码 603-622 doi: 10.15302/J-FASE -2021397
The COVID-19 infections caused by SARS-CoV-2 have resulted in millions of people being infected and thousands of deaths globally since November 2019. To date, no unique therapeutic agent has been developed to slow the progression of this pandemic. Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated. This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19. These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission. This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns. In addition, the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed. Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection. Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat.
微生物源性抗菌肽在可持续农业中的生物前景 Review
林书华, 陈选, 陈惠敏, 蔡茜茜, 陈旭, 汪少芸
《工程(英文)》 2023年 第27卷 第8期 页码 222-233 doi: 10.1016/j.eng.2022.08.011
为满足可持续农业发展体系构建的需求,本文开发了一种可用于替代传统抗生素的策略。该策略指出了一种可用作传统抗生素的替代品——抗菌肽(AMPs),其具有广谱抗菌活性和多靶点抗菌机制的特点。长期以来,研究人员一直致力从微生物中开发抗菌肽,该类微生物代谢活跃可适应各种极端环境。因此,在前人研究基础上,本文基于微生物源抗菌肽的的生物活性、抗菌机制、制备方法和其在农业生产应用中面临的挑战,开发了一种策略,以期为可持续农业发展中抗菌肽的应用提供理论指导。
2014—2016年食品动物源RE-cmeABC阳性弯曲菌流行与耐药性现状 Article
刘德俊, 刘蔚雯, 李星, 姚红, 沈张奇, 汪洋, 沈建忠
《工程(英文)》 2020年 第6卷 第1期 页码 34-39 doi: 10.1016/j.eng.2019.10.013
弯曲菌是引起人类胃肠炎的一类重要食源性致病菌。RE-CmeABC是近年来弯曲菌中新发现的一种增强型耐药外排泵,可介导对兽医和人医临床治疗弯曲菌感染的重要药物,如氟喹诺酮类、酰胺醇类、大环内酯类及四环素类等药物的高水平耐药,而目前尚未有对该外排泵的大范围流行病学调查。因此,本研究调查了2014—2016年连续三年间我国山东、上海和广东等三个重点养殖区食品动物源RE-cmeABC阳性弯曲菌的流行与耐药性现状。结果显示,在1088株弯曲菌(931株结肠弯曲菌与157株空肠弯曲菌)中共检测出122株(11.2%)RE-cmeABC阳性菌株,包括111株(70.7%)空肠弯曲菌与11株(1.2%)结肠弯曲菌,空肠弯曲菌中RE-cmeABC的阳性率显著高于结肠弯曲菌。111株RE-cmeABC阳性空肠弯曲菌与46株RE-cmeABC阴性空肠弯曲菌相比在氟苯尼考、克林霉素和红霉素的耐药率上具有显著差异(P < 0.05),而在环丙沙星、四环素和庆大霉素的耐药率上无显著差异。然而,携带RE-cmeABC的菌株可以使环丙沙星与四环素对弯曲菌的MIC值分布趋于更高水平范围。脉冲场凝胶电泳分型(PFGE)结果显示RE-cmeABC阳性菌株在上海和广东地区以水平传播为主,在山东地区以克隆传播为主;三株分离于上海和广东的阳性菌为同一克隆型,4株分离于上海和山东的阳性菌为同一克隆型。本研究表明RE-cmeABC已在我国食品动物源弯曲菌中广泛流行,对公共卫生安全具有潜在威胁。
关键词: RE- cmeABC 弯曲菌 环丙沙星 氟苯尼考
T. G. YUDINA, Danyang GUO, N. F. PISKUNKOVA, I. B. PAVLOVA, L. L. ZAVALOVA, I. P. BASKOVA
《化学科学与工程前沿(英文)》 2012年 第6卷 第2期 页码 203-209 doi: 10.1007/s11705-012-1277-2
关键词: recombinant destabilase-lysozyme (rec.Dest-Lys) antimicrobial activity antifungal activity medicinal leech heated-up derivative of rec.Dest-Lys (T-rec.Dest-Lys)
标题 作者 时间 类型 操作
Antimicrobial use in food animal production: situation analysis and contributing factors
Ziping WU
期刊论文
Discovery of novel ursolic acid derivatives as effective antimicrobial agents through a ROS-mediated
期刊论文
of copper nanoparticles on multiwalled carbon nanotubes modified with poly (acrylic acid) and their antimicrobial
Li SHENG,Shuhang HUANG,Minghao SUI,Lingdian ZHANG,Lei SHE,Yong CHEN
期刊论文
Microwave-assisted synthesis and antimicrobial activities of 2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin
Hua CHEN, Yanan LI, Jie BAI, Lian ZHAO, Xiangguo YUAN, Xiaoliu LI, Keqiang CAO
期刊论文
Antimicrobial activity of topical agents against Propionibacterium acnes: an in vitro study of clinical
null
期刊论文
越南广平和顺化两省猪场分离副猪嗜血杆菌的抗生素耐药表型和耐药基因之间的相关性研究
Chao Nguyen Van, 张丽君, Tam Vu Thi Thanh, Hung Pham Hoang Son, Tuan Tran Ngoc, 黄琦, 周锐
期刊论文
吖啶– 核定位序列偶联构建的高活性抗菌肽
Wei Zhang,Xiaoli Yang,Jingjing Song,Xin Zheng,Jianbo Chen,Panpan Ma,Bangzhi Zhang,Rui Wang
期刊论文
Strategies on designing multifunctional surfaces to prevent biofilm formation? ?
Yang Lu,Zhanguo Yue,Wei Wang,Zhiqiang Cao
期刊论文
Multifunctional antimicrobial chlorhexidine polymers by remote plasma assisted vacuum deposition
Ana Mora-Boza, Francisco J. Aparicio, María Alcaire, Carmen López-Santos, Juan P. Espinós, Daniel Torres-Lagares, Ana Borrás, Angel Barranco
期刊论文
ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2: A SYSTEMATIC REVIEW
期刊论文