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High-intensity focused ultrasound tumor ablation: Review of ten years of clinical experience

Lian ZHANG, Zhi-Biao WANG

《医学前沿（英文）》 2010年第4卷第3期页码 294-302 doi: 10.1007/s11684-010-0092-8

摘要： High-intensity focused ultrasound (HIFU) is a technique to destroy tissue at depth within the body, selectively and without harming overlying and adjacent structures within the path of the beam because the ultrasonic intensity at the beam focus is much higher than that outside of the focus. Diagnostic ultrasound is the first imaging modality used for guiding HIFU ablation. In 1997, a patient with osteosarcoma was first successfully treated with ultrasound imaging-guided HIFU in Chongqing, China. Over the last decade, thousands of patients with uterine fibroids, liver cancer, breast cancer, pancreatic cancer, bone tumors, and renal cancer have been treated with ultrasound imaging-guided HIFU. Based on several research groups’ reports, as well as our ten-year clinical experience, we conclude that this technique is safe and effective in treating human solid tumors. HIFU is a promising technique. Most importantly, HIFU offers patients another alternative when those patients have no other treatment available.

关键词： high-intensity focused ultrasound (HIFU) ultrasound imaging-guided HIFU (USgHIFU) magnetic resonance imaging-guided HIFU (MRgHIFU)

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基于超声引导的高精度机器人辅助HIFU 乳腺癌治疗系统 Article

Tianhan Tang,Takashi Azuma,Toshihide Iwahashi,Hideki Takeuchi,Etsuko Kobayashi,Ichiro Sakuma

《工程（英文）》 2018年第4卷第5期页码 702-713 doi: 10.1016/j.eng.2018.07.008

摘要：高强度聚焦超声（波）（HIFU）是一种很有前景的非介入式治疗方法。为了提高HIFU 治疗的精确度和降低治疗成本，开发了一套基于超声引导（US）的五自由度辅助HIFU 系统。搭建了一套功能齐全的样机，它可以轻松地实现三维超声图像重建、目标分割、治疗路径生成和HIFU 自动照射等功能。利用线模型实现点定位，并且在异构组织模型上对凝固区域进行评估。在超声引导下，HIFU 治疗区域的中心偏离目标治疗区域中心不到2 mm。规划治疗区域周围出现的超调值远低于在临床使用的允许值。对于乳腺癌的治疗，本系统有足够的准确性。

关键词： HIFU 乳腺癌超声引导医疗机器人准确性评估