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三态组织 1

跨模态检索；鲁棒学习；对齐修正；贝塔混合模型 1

近β锻造 1

钛合金 1

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Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

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《医学前沿（英文）》 2011年第5卷第1期页码 101-105 doi: 10.1007/s11684-011-0111-4

摘要：

It has been demonstrated that β-elemene could protect against carbon tetrachloride (CCl₄)-induced liver fibrosis in our laboratory work, and the aim of this paper is to reveal the protective mechanisms of β-elemene. The hepatic fibrosis experimental model was induced by the hypodermical injection of CCl₄ in Wistar male rats. β-elemene was intraperitoneally administered into rats for 8 weeks (0.1 mL/100 g bodyweight per day), and plasma endotoxin content was assayed by biochemistry. The serum TNF-α level was detected using radioactive immunity. CD14 expression in rat livers was measured by immunohistochemistry and Western blot. The results showed that β-elemene can downregulate the levels of plasma endotoxins, serum TNF-α, and hepatic CD14 expression in rats with liver fibrosis. β-elemene plays an important role in downregulating the lipopolysaccharide signal transduction pathway, a significant pathway in hepatic fibrosis development.

关键词： liver fibrosis beta-elemene endotoxin CD14

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Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

《医学前沿（英文）》 2009年第3卷第1期页码 36-40 doi: 10.1007/s11684-009-0020-y

摘要： This study aims to investigate the influence of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptor type 1 (AT1R) in hepatic stellate cells (HSCs). , HSC-T6 were cultured for 24 hours and then treated with different doses of β-elemene (2.5, 5 and 10 mg/L). A control group was also set up. The secretion of ANG II in the supernatant was detected by radioimmunoassay. The mRNA expression of AT1R at 4, 12 and 24 h after treatment was detected by reverse transcription-polymerase chain reaction (RT-PCR), respectively. The protein expression of AT1R was detected by western blot. At the 4th h, the ANG II secretion in the supernatant was significantly inhibited by 10 mg/L β-elemene compared with the control group ( <0.05), while 5.0 mg/L and 2.5 mg/L β-elemene had no inhibitory effect on the secretion of ANG II ( >0.05). At the time point of the 12th h, the secretion of ANG II in the supernatant treated with 10 mg/L and 5.0 mg/L β-elemene was significantly lower than the control ( <0.01, <0.05). Following the treatment with 5.0 mg/L and 2.5 mg/L β-elemene for 24 h, significant inhibition of ANG II secretion was observed ( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1R mRNA in HSCs after the treatment for 4, 12, and 24 h in a dose-dependent manner. The expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene can inhibit the secretion of ANG II and the gene and protein expression of AT1R, which may be the mechanism by which β-elemene prevents the progress of hepatic fibrosis.

关键词： liver cirrhosis beta-elemene hepatic stellate cells angiotensin II receptor angiotensin type 1

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Beta-cyclodextrin adsorbents to remove water pollutants—a commentary

《化学科学与工程前沿（英文）》 2022年第16卷第9期页码 1407-1423 doi: 10.1007/s11705-022-2146-2

摘要： Beta-cyclodextrin-based adsorbent is a promising adsorbent because it has unique characteristics and able to form host-guest complexes with various organic compounds. Adsorption using beta-cyclodextrin-based adsorbent has continuously improved by various preparation strategies and crosslinking agents. This commentary aims to highlight the preparation strategies, properties, and adsorption mechanisms of beta-cyclodextrin-based adsorbents. The adsorbents can be generally classified according to the preparation methods and display high adsorption capacity especially for dyes. Particularly, composite/nanocomposite beta-cyclodextrin-based adsorbents exhibit outstanding adsorption capacity even though the surface area is lower than that of porous and magnetic beta-cyclodextrin-based adsorbents. The beta-cyclodextrin/chitosan functionalized graphene oxide hydrogel with specific surface of 17.6 m²·g^–1 yields an extraordinarily maximum adsorption capacity of 1499 mg·g^–1 methylene blue, while beta-cyclodextrin/chitosan modified with iron(II, III) oxide nanoparticles displays a much greater maximum adsorption capacity at 2780 mg·g^–1. The hydrophobic interaction, functional groups, hydrogen bonding, and electrostatic interaction govern the adsorption to a greater capacity. Although this commentary is not exhaustive, the preparation strategies and illustrated mechanisms provide useful insights into the adsorbent–adsorbate interactions, cost-effective analysis, challenges, and future directions of beta-cyclodextrin-based adsorbents in wastewater treatment.

关键词： beta-cyclodextrin adsorbent adsorption inclusion complex mechanism water pollutant wastewater treatment

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Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

《医学前沿（英文）》 2007年第1卷第1期页码 41-45 doi: 10.1007/s11684-007-0008-4

摘要： The dendritic cell vaccine is a treatment vaccine with potent clinical applications. Functional cytokines can enhance dendritic cell anti-tumor immune responses. This experiment was conducted to study the effects of bone marrow-deriv

关键词： Functional experiment anti-tumor dendritic clinical

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K on the low-temperature hydrothermal stability of Cu/SAPO-34 and its synergic application with Fe/Beta

Chen Wang, Jun Wang, Jianqiang Wang, Meiqing Shen

《环境科学与工程前沿（英文）》 2021年第15卷第2期 doi: 10.1007/s11783-020-1322-1

摘要： Abstract • K+ hinder the structural degradation of Cu/SAPO-34 under humid condition<100°C. • K+ on Cu/SAPO-34 brings lower acidity and inferior SCR activity at high temperature. • Fe/Beta was used to compensate the low activity of Cu/SAPO-34 at high temperature. • The hybrid catalysts with KCu/SAPO-34 and Fe/Beta show a great potential for using. K ions were introduced onto Cu/SAPO-34 catalysts via the ion-exchange process in order to improve their stability under low-temperature hydrothermal aging. The changes in structure and copper-species contents of these catalysts upon hydrothermal aging were probed in order to investigate their effects on selective catalytic reduction (SCR) activity. For the fresh Cu/SAPO-34 catalysts, K ions had little influence on the chabazite framework but effected their acidities by exchanging with acid sites. After hydrothermal aging, the structural integrity and amount of active sites decreased on pure Cu/SAPO-34. While the K-loaded catalysts showed improved chabazite structure, acidity, and active site conservation with increasing K loading. However, although the 0.7 wt% K catalyst maintained the same crystallinity, active site abundance, and low-temperature SCR activity as the fresh catalyst upon aging, an apparent decrease in SCR activity at high temperature was observed because of the inevitable decrease in the number of Brönsted acid sites. To compensate for the activity disadvantage of K-loaded Cu/SAPO-34 at high temperature, Fe/Beta catalysts were co-employed with K-loaded Cu/SAPO-34, and a wide active temperature window of SCR activity was obtained. Thus, our study reveals that a combined system comprising Fe/Beta and K-loaded Cu/SAPO-34 catalysts shows promise for the elimination of NOx in real-world applications.

关键词： Selective catalytic reduction Cu/SAPO-34 catalyst Ion-exchanged K Low-temperature hydrothermal stability Fe/Beta catalyst

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Detection of presumed genes encoding beta-lactamases by sequence based screening of metagenomes derived

Gastón Azziz, Matías Giménez, Héctor Romero, Patricia M. Valdespino-Castillo, Luisa I. Falcón, Lucas A. M. Ruberto, Walter P. Mac Cormack, Silvia Batista

《环境科学与工程前沿（英文）》 2019年第13卷第3期 doi: 10.1007/s11783-019-1128-1

摘要：

• Beta-lactamase genes were found in all samples from distant places in Antarctica.

• Class C beta-lactamase coding genes were the most frequently found.

• Diversity of sequences exceeds that of the beta-lactamases from clinical environment.

关键词： Beta-lactamases Antibiotic resistance coding genes Metagenomes Antarctic microbial mats

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Subsurface damage pattern and formation mechanism of monocrystalline -GaO in grinding process

《机械工程前沿（英文）》 2022年第17卷第2期 doi: 10.1007/s11465-022-0677-3

摘要： Monocrystalline beta-phase gallium oxide (β-Ga₂O₃) is a promising ultrawide bandgap semiconductor material. However, the deformation mechanism in ultraprecision machining has not yet been revealed. The aim of this study is to investigate the damage pattern and formation mechanism of monocrystalline β-Ga₂O₃ in different grinding processes. Transmission electron microscopy was used to observe the subsurface damage in rough, fine, and ultrafine grinding processes. Nanocrystals and stacking faults existed in all three processes, dislocations and twins were observed in the rough and fine grinding processes, cracks were also observed in the rough grinding process, and amorphous phase were only present in the ultrafine grinding process. The subsurface damage thickness of the samples decreased with the reduction in the grit radius and the grit depth of cut. Subsurface damage models for grinding process were established on the basis of the grinding principle, revealing the mechanism of the mechanical effect of grits on the damage pattern. The formation of nanocrystals and amorphous phase was related to the grinding conditions and material characteristics. It is important to investigate the ultraprecision grinding process of monocrystalline β-Ga₂O₃. The results in this work are supposed to provide guidance for the damage control of monocrystalline β-Ga₂O₃ grinding process.

关键词： monocrystalline beta-phase gallium oxide grinding process subsurface damage nanocrystals amorphous phase

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Pelagic-benthic coupling of the microbial food web modifies nutrient cycles along a cascade-dammed river

《环境科学与工程前沿（英文）》 2022年第16卷第4期 doi: 10.1007/s11783-021-1484-5

摘要：

• Structure of multi-trophic microbial groups were analyzed using DNA metabarcoding.

关键词： Reservoir Multi-trophic Beta diversity Predator-prey Nutrient accumulation

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基于对齐自修正的鲁棒跨模态检索 Research Article

郭金一1,丁洁玉2

《信息与电子工程前沿（英文）》 2023年第24卷第10期页码 1403-1415 doi: 10.1631/FITEE.2200514

摘要：跨模态检索通过为不同模态数据建立一致的对齐方式来实现模态间的相互检索。目前多种跨模态检索方法已被提出并取得良好性能。这些方法使用干净对齐的跨模态数据进行训练。虽然这些数据在语义上是匹配的，但相较于互联网上容易获得的噪声对齐的数据（即成对但在语义上不匹配），标注成本很高。当用噪声对齐的数据训练这些模型时，它们的性能会急剧下降。因此，本文提出一种对齐自修正的鲁棒跨模态检索算法（RCAR），显著降低了噪声数据对模型的影响。具体来说，RCAR首先进行多任务学习，减缓模型对噪声数据的过拟合，使数据分离。然后，利用两成分的贝塔混合模型将数据分为干净数据和噪声数据，并根据后验概率修正对齐标签。此外，在噪声对齐范式中定义两种噪声类型：部分噪声数据和完全噪声数据。实验结果表明，与当下流行的跨模态检索方法相比，RCAR在两种类型的噪声下都能取得更稳健的性能。

关键词：跨模态检索；鲁棒学习；对齐修正；贝塔混合模型

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近β锻造推翻陈旧理论发展了三态组织

周义刚,曾卫东,俞汉清

《中国工程科学》 2001年第3卷第5期页码 61-66

摘要：近β锻造的组织不再是等轴α量过多，或是为零的网篮条状α的结构模式；而是约含20%等轴α、50%～60%条状α构成的网篮和β转变基体组成的三态组织近β锻造适用于（α+β)型合金，还可应用于α、近α和近β型合金，其研究成果已用于制造了多种发动机盘件、飞机和导弹等重要结构件。

关键词：钛合金近β锻造三态组织

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Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation

Dai-Hai YU PhD, Jian-Feng HUANG MD, Ji-Chun CHEN MS, Jie CAO MS, Shu-Feng CHEN PhD, Dong-Feng GU MD, PhD, for the GenSalt Collaborative Research Group, De-Pei LIU PhD, Lai-Yuan WANG PhD, Jing CHEN MD, MSc, Jiang HE MD, PhD, Cashell E. JAQUISH PhD, Dabeeru C. RAO PhD, Charles GU PhD, James E. HIXSON PhD, Chung-Shiuan CHEN MS⁸, Paul K. WHELTON MD, MSc⁹,

《医学前沿（英文）》 2010年第4卷第1期页码 59-66 doi: 10.1007/s11684-010-0015-8

摘要： Dietary potassium-supplementation has been associated with a decreased risk of hypertension and other cardiovascular outcomes. However, blood pressure (BP) responses to potassium supplementation vary among individuals. This study was designed to examine the association between 12 single nucleotide polymorphisms (SNPs) in the adducin 1 alpha (ADD1) and guanine nucleotide binding protein (G protein) beta polypeptide 3 (GNB3) genes and systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP) responses to potassium-supplementation. We conducted a 7-day high-sodium intervention (307.8 mmol sodium/day) followed by a 7-day high-sodium with potassium-supplementation (60 mmol potassium/day) among 1906 Han Chinese participants from rural north China. BP measurements were obtained at the end of each intervention period using a random-zero sphygmomanometer. We identified significant associations between ADD1 variant rs17833172 and SBP, DBP, and MAP responses to potassium-supplementation (all <0.0001) that remained significant after adjustment for multiple comparisons. In participants that were heterozygous or homozygous for the G allele of this marker, SBP, DBP, and MAP response to potassium-supplementation were −3.52 (−3.82, −3.21), −1.41 (−1.66, −1.15) and −2.12 (−2.37, −1.87), respectively, as compared to the corresponding responses of 1.99 (0.25, 3.73), −0.65 (−0.10, −0.21), and −0.23 (−0.37, 0.83), respectively, for those who were homozygous for A allele. In addition, participants with at least one copy of the G allele of rs12503220 of the ADD1 gene had significantly increased DBP and MAP response to potassium-supplementation ( = 0.0041 and 0.01, respectively), which was also significant after correction for multiple testing. DBP and MAP responses to potassium-supplementation were −1.36 (−1.63, −1.10) and −2.07 (−2.32, −1.82) for those with at least G allele compared to corresponding responses of 0.86 (−0.68, 2.40) and −0.45 (−1.74, 0.84) for those who were homozygous for A allele. In summary, our study identified novel associations between genetic variants of the ADD1 gene and BP response to potassium-supplementation, which could have important clinical and public health implications. Future studies aimed at replicating these novel findings are warranted.

关键词： blood pressure genetics polymorphism die-tary potassium potassium sensitivity adducin 1 alpha (ADD1) guanine nucleotide binding protein beta polypeptide 3 (GNB3)

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标题作者时间类型操作

Downregulation effects of beta-elemene on the levels of plasma endotoxin, serum TNF-alpha, and hepatic

null

期刊论文

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

期刊论文

Beta-cyclodextrin adsorbents to remove water pollutants—a commentary

期刊论文

Immunotherapeutic effects on murine pancreatic carcinoma by β-elemene combined with dendritic cells modified

TAN Guang, WANG Zhongyu, CHE Luanqing, YIN Shuo

期刊论文

K on the low-temperature hydrothermal stability of Cu/SAPO-34 and its synergic application with Fe/Beta

Chen Wang, Jun Wang, Jianqiang Wang, Meiqing Shen

期刊论文

Detection of presumed genes encoding beta-lactamases by sequence based screening of metagenomes derived

Gastón Azziz, Matías Giménez, Héctor Romero, Patricia M. Valdespino-Castillo, Luisa I. Falcón, Lucas A. M. Ruberto, Walter P. Mac Cormack, Silvia Batista

期刊论文

Subsurface damage pattern and formation mechanism of monocrystalline -GaO in grinding process

期刊论文

Pelagic-benthic coupling of the microbial food web modifies nutrient cycles along a cascade-dammed river

期刊论文

基于对齐自修正的鲁棒跨模态检索

郭金一1,丁洁玉2

期刊论文

近β锻造推翻陈旧理论发展了三态组织

周义刚,曾卫东,俞汉清

期刊论文

Genetic variants in the ADD1 and GNB3 genes and blood pressure response to potassium supplementation