资源类型

期刊论文 4

年份

2021 1

2010 2

2008 1

关键词

化疗敏感性 1

吉西他滨 1

外周血单核细胞 1

肝内胆管癌 1

检索范围：

排序： 展示方式：

Hilar cholangiocarcinoma: Pathology and tumor biology

Dong KUANG, Guo-Ping WANG,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 371-377 doi: 10.1007/s11684-010-0130-6

摘要： Hilar cholangiocarcinoma, first described by Klatskin in 1965, is a relatively rare tumor arising from the bile ducts. The histomorphological features of hilar cholangiocarcinoma are identical with other extra- and intra-hepatic bile duct carcinomas. The most common disease associated with cholangiocarcinoma is primary sclerosing cholangitis. The development of cholangiocarcinoma is a multistep process associated with several mutations in oncogenes and tumor-suppressor genes. Based on macroscopic appearance, three distinct subtypes have been described: sclerosing, nodular, and papillary. Microscopically, more than 95% of tumors are adenocarcinomas. Hilar cholangiocarcinoma is a slowly growing tumor and tends to spread longitudinally along the bile ducts with neural, perineural, and subepithelial extension. Lymph node invasion can be found in 30%–50% patients at the time of diagnosis, but blood-born metastases are rare and usually occur at late stages.

关键词： hilar cholangiocarcinoma     morphology     primary sclerosing cholangitis     metastasis     growth    

HTML PDF 收藏

Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 457-462 doi: 10.1007/s11684-010-0240-1

摘要： This study was performed to determine the prognostic role of preoperative serum carbohydrate antigen (CA) 19-9 levels in the survival of patients with cholangiocarcinoma. Articles published up to June 1, 2010 that evaluated preoperative CA19-9 levels and the prognosis of cholangiocarcinoma were collected for meta-analysis. The required information for calculating individual relative risk (RR) was extracted from the studies, and a combined overall RR was estimated. Nine eligible studies were included. One study dealt with extra-hepatic cholangiocarcinoma, while the other eight studies analyzed intra-hepatic cholangiocarcinoma. The mean methodological quality score was 74.1%, ranging from 65.5% to 82.5%. The overall RR for the nine studies was 1.28 (95% confidence interval= 1.10–1.46), and the Z-score for overall effect was 13.83 (<0.001). The association between serum CA19-9 level and lymph node involvement was also assessed. The combined RR was 1.471 (95% confidence interval= 0.411–5.264) and Z-score for overall effect was 0.59 ( = 0.553). CA19-9 levels were associated significantly with the prognosis of patients with cholangiocarcinoma. This meta-analysis shows that elevation of preoperative CA19-9 levels is correlated with a poor prognosis of patients with cholangiocarcinoma. However, larger scale and randomized studies are needed to draw a more substantive conclusion.

关键词： cholangiocarcinoma     prognostic factors     serum carbohydrate antigen 19-9    

HTML PDF 收藏

Diagnosis and treatment for advanced hilar cholangiocarcinoma: experience of 24 cases

ZHANG Zongming, ZHU Jianping, SU Yanming, GUO Jinxing, JIANG Nan, ZHANG Zichao, XING Hailin, LIU Kai, YUAN Haiming

《医学前沿（英文）》 2008年 第2卷 第2期   页码 134-138 doi: 10.1007/s11684-008-0025-y

摘要： The aim of this paper is to evaluate the efficacy of the surgical treatment for advanced hilar cholangiocarcinoma (CCA) in order to improve the resection rate and curative effect. A retrospective analysis was performed on the data of 24 patients who had undergone surgical treatment for advanced hilar CCA. According to the Bismuth classification, there were four cases of type IIIa, six cases of type IIIb, and 14 cases of type IV. Based on the treatment approaches, these patients were divided into three groups: $` Radical resection group: There were five cases (one type IIIa, three type IIIb, and one type IV). The tumor visible to the naked eyes was resected thoroughly and the cut margin was free of tumor by microscopic examination. Then, Roux-en-Y hepatico-jejunal anastomosis was performed to restore the bile flow. $a Palliative resection group: There were 11 cases. The bile flow was restored by Roux-en-Y hepatico-jejunal anastomosis directly in five cases (two type IIIa, three type IIIb) and by internal drainage through a hepatico-jejunal bridge in the other six cases (one type IIIa, five type IV). $b Simple internal biliary drainage group: There were eight cases of type IV, including three cases with the internal drainage through hepatico-jejunal bridge by laparotomy, three cases with endoscopic retrograde biliary drainage (ERBD), two cases with percutaneous transhepatic biliary drainage (PTBD). The rate of radical resection was 20.8% and the overall resection rate was 66.7%. All of the 24 patients were followed-up. The cumulative surviving rates were significantly different among these three groups (Log-rank = 17.56, = 0.0002). For advanced hilar CCA, the best choice of treatment is radical resection. If radical resection is impractical, palliative resection combined with partial hepatectomy can significantly prolong the survival time. Internal drainage through a hepatico-jejunal bridge can enhance the surgical resection rate and decrease the occurrence rate of postoperative biliary leakage.
HTML PDF 收藏

外周血免疫特征预测肝内胆管癌患者化疗敏感性 Article

吴彤, 杨应成, 郑博, 施学兵, 李炜, 马文聪, 王珊, 李祉萱, 朱妍静, 吴建民, 汪凯婷, 赵燕, 伍睿, 隋成军, 莘似韵, 吴璇, 陈磊, 袁振刚, 王红阳

《工程（英文）》 2021年 第7卷 第10期   页码 1381-1393 doi: 10.1016/j.eng.2021.01.014

摘要：

肝内胆管癌（ICC）是第二常见肝癌。化疗仍然是晚期ICC患者的主要治疗方法，但是化疗敏感性因人而异。在本研究中，我们使用飞行时间质谱仪（CyTOF）在单细胞水平上建立ICC患者在化疗前、化疗中和化疗后指定时间点外周血单核细胞（PBMC）的免疫谱；应用多重免疫荧光染色展现某些特定免疫亚群的空间分布；使用组织微阵列（TMA）评估患者预后。本研究共招募了20名接受吉西他滨（GEM）治疗的ICC患者，其中8例对化疗反应良好（R），12例无反应（NR）。我们观察到化疗后患者PBMC组成发生了巨大变化，比如CD4/CD8 双阳性T细胞（DPT）水平增加。治疗前CD4+CD45RO+CXCR3+T细胞水平较高的患者对化疗反应良好。我们的研究确定了T细胞亚群的百分比与患者化疗反应性之间存在正相关关系，这表明通过评估PBMC中细胞亚群的比例来预测ICC患者化疗反应性是可行的。

关键词： 肝内胆管癌     吉西他滨     化疗敏感性     外周血单核细胞    

HTML PDF 收藏

标题 作者 时间 类型 操作

Hilar cholangiocarcinoma: Pathology and tumor biology

Dong KUANG, Guo-Ping WANG,

期刊论文

Serum carbohydrate antigen (CA) 19-9 as a prognostic factor in cholangiocarcinoma: A meta-analysis

Shang-Long LIU, Zi-Fang SONG, Qing-Gang HU, Shao-Bo HU, Jun LI, Qi-Chang ZHENG, Duo SHAN,

期刊论文

Diagnosis and treatment for advanced hilar cholangiocarcinoma: experience of 24 cases

ZHANG Zongming, ZHU Jianping, SU Yanming, GUO Jinxing, JIANG Nan, ZHANG Zichao, XING Hailin, LIU Kai, YUAN Haiming

期刊论文

外周血免疫特征预测肝内胆管癌患者化疗敏感性

吴彤, 杨应成, 郑博, 施学兵, 李炜, 马文聪, 王珊, 李祉萱, 朱妍静, 吴建民, 汪凯婷, 赵燕, 伍睿, 隋成军, 莘似韵, 吴璇, 陈磊, 袁振刚, 王红阳

期刊论文