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核能发展国际高端论坛 International Summit on Nuclear Energy Development

会议日期： 2019年05月15日

会议地点：中国

主办单位：中国工程院

核能发展国际高端论坛 International Summit on Nuclear Energy Development

会议日期： 2019年05月15日

会议地点：中国

主办单位：中国工程院

Innovative development path of ethnomedicines: the interpretation of the path

null

《医学前沿（英文）》 2017年第11卷第1期页码 32-47 doi: 10.1007/s11684-016-0495-2

摘要：

One of the primary purposes of the innovative development of ethnomedicines is to use their excellent safety and significant efficacy to serve a broader population. To achieve this purpose, modern scientific and technological means should be referenced, and relevant national laws and regulations as well as technical guides should be strictly followed to develop standards and to perform systemic research in producing ethnomedicines. Finally, ethnomedicines, which are applied to a limited extent in ethnic areas, can be transformed into safe, effective, and quality-controllable medical products to relieve the pain of more patients. The innovative development path of ethnomedicines includes the following three primary stages: resource study, standardized development research, and industrialization of the achievements and efforts for internationalization. The implementation of this path is always guaranteed by the research and development platform and the talent team. This article is based on the accumulation of long-term practice and is combined with the relevant disciplines, laws and regulations, and technical guidance from the research and development of ethnomedicines. The intention is to perform an in-depth analysis and explanation of the major research thinking, methods, contents, and technical paths involved in all stages of the innovative development path of ethnomedicines to provide useful references for the development of proper ethnomedicine use.

关键词： ethnomedicines innovative development path resource study standardized development research industrialization internationalization

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Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

null

《医学前沿（英文）》 2017年第11卷第4期页码 590-594 doi: 10.1007/s11684-017-0537-4

摘要：

Grading of Recommendations Assessment, Development, and Evaluation (GRADE) offers a worldwide approach to guideline development for clinical practice. For the clinical practice of acupuncture therapy, 18 evidence-based guidelines have been developed in China using GRADE. In this study, we review the advantages and limitations of the GRADE approach in the guideline development for acupuncture and moxibustion and propose some solutions to these limitations. Scientific advantages of rating the quality of evidence, outcome-centric direction, overall progression to develop recommendations, and strength of recommendations providing specific clinical guidance are the advantages of GRADE. The limitations of GRADE in the development of guidelines for acupuncture and moxibustion include rating the quality of evidence for ancient literature and literature on famous traditional Chinese medicine experts’ experiences and specific guidelines for formulating recommendations from evidence. In the guideline development for clinical practice with acupuncture and moxibustion, we suggest that a specific method should be explored based on the GRADE approach and the characteristics of acupuncture therapy.

关键词： guideline acupuncture GRADE

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Lean Product Development—Faster, Better … Cleaner?

Geert Letens

《工程管理前沿（英文）》 2015年第2卷第1期页码 52-59 doi: 10.15302/J-FEM-2015007

摘要： To address this challenge, lean product development has emerged to become the leading improvement methodology for companies toward the creation of a competitive advantage on innovation and technology leadership. While lean product development has its origin in the best practice studies of Japanese car manufacturers such as Toyota, it has been further elaborated in defence and aerospace organizations over the last two decades, and recently empirical evidence has become available for successful introductions in sectors different from the traditionally-studied environments. The primary purpose of this work is to untangle the fuzziness that still surrounds lean product development and to ground the key aspects of lean product development based on insights from six studies published in a special issue of the on this topic. This demonstrates how better and faster product development can be achieved through the integration of lean principles with the best of more traditional new product development (NPD) practices, into a holistic system that can be characterised by value-focused and risk-based decision making, the socio-technical integration of people and process, improved project, pipeline and portfolio management, optimized knowledge management, and the creation of a learning organization. Unfortunately, while the increasing global competition offers the potential to improve the quality of life for many, the spirit of faster, better, and cheaper also threatens to endanger the future of our planet as a whole. As the majority of a product’s social and ecological impacts are committed in the design phase, it, therefore, seems imperative to investigate the integration of lean product development and eco-design principles. As a result, this work also explores the symbiosis of both approaches through the identification of tools and methods that can support the triple bottom-line goals for a sustainable future of life and business.

关键词： lean product development sustainability engineering responsible design

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The development and benefits of metformin in various diseases

《医学前沿（英文）》 2023年第17卷第3期页码 388-431 doi: 10.1007/s11684-023-0998-6

摘要： Metformin has been used for the treatment of type II diabetes mellitus for decades due to its safety, low cost, and outstanding hypoglycemic effect clinically. The mechanisms underlying these benefits are complex and still not fully understood. Inhibition of mitochondrial respiratory-chain complex I is the most described downstream mechanism of metformin, leading to reduced ATP production and activation of AMP-activated protein kinase (AMPK). Meanwhile, many novel targets of metformin have been gradually discovered. In recent years, multiple pre-clinical and clinical studies are committed to extend the indications of metformin in addition to diabetes. Herein, we summarized the benefits of metformin in four types of diseases, including metabolic associated diseases, cancer, aging and age-related diseases, neurological disorders. We comprehensively discussed the pharmacokinetic properties and the mechanisms of action, treatment strategies, the clinical application, the potential risk of metformin in various diseases. This review provides a brief summary of the benefits and concerns of metformin, aiming to interest scientists to consider and explore the common and specific mechanisms and guiding for the further research. Although there have been countless studies of metformin, longitudinal research in each field is still much warranted.

关键词： metformin metabolism cancer aging neurological disorder

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Strategic position and development prospects of nuclear energy in China

SHEN Wenquan

《能源前沿（英文）》 2007年第1卷第2期页码 125-128 doi: 10.1007/s11708-007-0015-9

摘要： By analyzing the challenges of China s energy supply, an excellent perspective of nuclear power development in the country has been described. Taking into account the near-, mid-, and long-term development requirements, a comprehensive, coordinated and sustainable nuclear power program is proposed. Thus, our national nuclear industry can not only catch up with the world s advanced level in proper time, but also possess enough stamina for sustainability.

关键词： development excellent perspective long-term development comprehensive national

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SUSTAINABLE DEVELOPMENT OF CROP-LIVESTOCK FARMS IN AFRICA

《农业科学与工程前沿（英文）》 2021年第8卷第1期

摘要：

Crop-livestock farms across Africa are highly variable due to in agroecological and socioeconomic factors, the latter shaping the demand and supply of livestock products. Crop-livestock farms in Africa in the 20-first century are very different from most mixed farms elsewhere in the world. African crop-livestock farms are smaller in size, have fewer livestock, lower productivity and less dependency on imported feed than farms in most countries of Europe, the Americas and the intensive agricultural systems of Asia. This paper discusses the role African crop-livestock farms have in the broader socio-agricultural economy, and how these are likely to change adapting to pressures brought on by the intensification of food systems. This intensification implies increasing land productivity (more food per hectare), often leading to more livestock heads per farm, producing fertilized feeds in croplands and importing feed supplements from the market. This discussion includes (1) the links between crop yields, soil fertility and crop-livestock integration, (2) the increasing demand for livestock products and the land resources required to meet to this demand, and (3) the opportunities to integrate broader societal goals into the development of crop-livestock farms. There is ample room for development of crop-livestock farms in Africa, and keeping integration as part of the development will help prevent many of the mistakes and environmental problems related to the intensification of livestock production observed elsewhere in the world. This development can integrate biodiversity, climate change adaptation and mitigation to the current goals of increasing productivity and food security. The inclusion of broader goals could help farmers access the level of finance required to implement changes.

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Increasing significance of advanced physical/chemical processes in the development and application of

RULKENS Wim

《环境科学与工程前沿（英文）》 2008年第2卷第4期页码 385-396 doi: 10.1007/s11783-008-0073-1

摘要： The awareness of the problem of the scarcity of water of high quality has strongly changed the approach of wastewater treatment. Currently, there is an increasing need for the beneficial reuse of treated wastewater and to recover valuable products and energy from the wastewater. Because microbiological treatment methods are, only to a limited part, able to satisfy these needs, the role and significance of physical/chemical processes in wastewater treatment are gaining more and more interest. The specific future role and aim of the various physical/chemical treatment processes can be categorized in five groups: improvement of the performance of microbiological treatment processes, achievement of the high quality required for reuse of the effluent, recovery of valuable components and energy from the wastewater for beneficial reuse, desalination of brackish water and seawater, and treatment of concentrated liquid or solid waste residues produced in a wastewater treatment process. Development of more environmentally sustainable wastewater treatment chains in which physical/chemical processes play a crucial role, also requires application of process control and modeling strategies. This is briefly introduced by the elaboration of treatment scenarios for three specific wastewaters.

关键词： control beneficial valuable scarcity Development

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Factors affecting early embryonic development in cattle: relevance for bovine cloning

Yanna DANG, Kun ZHANG

《农业科学与工程前沿（英文）》 2019年第6卷第1期页码 33-41 doi: 10.15302/J-FASE-2018228

摘要：

Female infertility represents a major challenge for improving the production efficiency in the dairy industry. Historically, fertility has declined whereas milk yield has increased tremendously due to intensive genetic selection. evidence reveals about 60% pregnancy loss takes place during the first month following fertilization. Meanwhile, early embryo development is significant for somatic cell nuclear transfer in cattle as a large proportion of cloned embryos fail to develop beyond peri-implantation stage. Oocyte quality is of utmost importance for the early embryo to develop to term for both fertilized and cloned embryos. Epigenetic reprogramming is a key process occurring after fertilization and critical roles of epigenetic modifiers during preimplantation development are now clear. Incomplete epigenetic reprogramming is believed to be a major limitation to cloning efficiency. Treatment of cloned embryos with epigenetic modifying drugs (e.g., Trichostatin A) could greatly improve cloning efficiency in both mice and cattle. Recently, the rapid progress in high-throughput sequencing technologies has enabled detailed deciphering of the molecular mechanisms underlying these events. The robust efficiency of genomic editing tools also presents an alternative approach to the functional annotation of genes critical to early development.

关键词： bovine cloning embryo development somatic cell nuclear transfer X-inactive specific transcript

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Review of sentiment analysis: An emotional product development view

《工程管理前沿（英文）》页码 592-609 doi: 10.1007/s42524-022-0227-z

摘要： Conveying consumers’ specific emotions in new products, referred to as emotional product development or emotional design, is strategically crucial for manufacturers. Given that sentiment analysis (SA) can extract and analyze people’s opinions, sentiments, attitudes, and perceptions regarding different products/services, SA-based emotional design may provide manufacturers with real-time, direct, and rapid decision support. Despite its considerable advancements and numerous survey and review articles, SA is seldom considered in emotional design. This study is among the first efforts to conduct a thorough review of SA from the view of emotional design. The comprehensive review of aspect-level SA reveals the following: 1) All studies focus on extracting product features by mixing technical product features and consumers’ emotional perceptions. Consequently, such studies cannot capture the relationships between technical and emotional attributes and thus cannot convey specific emotions to the new products. 2) Most studies use the English language in SA, but other languages have recently received more interest in SA. Furthermore, after conceptualizing emotion as Kansei and introducing emotional product development and Kansei Engineering, a review of the data-driven emotional design is then conducted. A few efforts start to study emotional design with the help of SA. However, these studies only focus on either analyzing consumers’ preferences on product features or extracting emotional opinions from online reviews, thus cannot realize data-driven emotional product development. Finally, some research opportunities are provided. This study opens a broad door to aspect-level SA and its integration with emotional product development.

关键词： sentiment analysis emotion product development Kansei Engineering

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Relationship between the development of energy and mineral resources and ecological conservation redline

Dawei ZHANG

《工程管理前沿（英文）》 2019年第6卷第4期页码 557-563 doi: 10.1007/s42524-019-0077-5

摘要： From a philosophical point of view, this study discusses the dialectical relationship between the development of energy and mineral resources and the ecological conservation redline. We propose that the ecological conservation redline and the development of energy and mineral resources should be guided by ecological civilization construction, that is, the energy and mineral resources should be rationally developed under the condition that the ecological environment is protected. This study analyzes the influence of the development of energy and mineral resources on the ecological environment. The handling of mining rights within the ecological conservation redline based on the law and the reduction of the influence of the development of energy mineral resources on the ecological environment by science and technology are presented. The environmental assessment system and technical standards for energy and mineral development are suggested to implement policies and measures for the disposal of mining rights within the redline and facilitate technological innovations of ecological conservation for energy and mineral development. Hence, a coordinated development between the ecological conservation redline and the development of energy and mineral resources can be promoted.

关键词： ecological conservation redline development of energy and mineral resources coordinated development

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Large-scale geo-energy development: Sustainability impacts

Li JIANG,Liandong ZHU,Erkki HILTUNEN

《能源前沿（英文）》 2019年第13卷第4期页码 757-763 doi: 10.1007/s11708-017-0455-9

摘要： Geothermal energy is a renewable and alternative energy with the potential to replace fossil fuels and help mitigate global warming. However, the development of geothermal energy has environmental, economic and social-cultural consequences, which needs to be predicted beforehand and then mitigated. To guarantee a sustainable development, it is, therefore, essential to consider the relative potential impacts. From a sustainability point of view, in the present study, a comprehensive analysis of consequences of geothermal energy development is conducted, including environmental, economic and societal & cultural dimensions. The geothermal energy industry will prosper only if sustainable aspects can be integrally considered.

关键词： geothermal energy sustainability impact development

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鄂尔多斯盆地油气勘探开发的实践与可持续发展

胡文瑞,翟光明

《中国工程科学》 2010年第12卷第5期页码 64-72

摘要：

鄂尔多斯盆地是我国近10年来石油天然气产量增长最快的盆地，目前已经成为我国第二大油气生产盆地和第一大天然气产区。概述了鄂尔多斯盆地油气勘探开发的历史，总结了盆地发展形成的重要认识、主要技术、开发管理模式、油气产量和取得的经济社会效益，从发展规划、油气资源、非常规油气资源和其他资源方面探讨了盆地发展前景，并对盆地可持续发展提出了建议。

关键词：鄂尔多斯盆地油气勘探开发可持续发展技术管理模式

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A Further Discussion on Trends in the Development of Advanced Manufacturing Technology

YANG Shu-zi, WU Bo, LI Bin

《机械工程前沿（英文）》 2006年第1卷第1期页码 1-5 doi: 10.1007/s11465-005-0002-y

摘要：

This paper is a supplement to Trends in the Development of Advanced Manufacturing Technology (Yang and Wu in Chin. J. Mech. Eng., 39: 73, 2003) but delves deeper into it. It first points out the strategic status of manufacturing industry in state development. Then, a detailed analysis is given on the features and trends in the development of advanced manufacturing technology in a total of 12 points from three aspects: precision, extreme, and culture from the aspect of the product itself; green, rapidness, saving, and efficiency during the manufacturing process; and digit, auto, integration, networking, and intelligence in view of the manufacturing method. In addition, it emphasizes that all the above aspects should be based on two base points: manufacture and machinery. Finally, it puts forth the guiding ideologies for the development of advanced manufacturing technology and the aspects China should give priority to in development, while stressing on the principles of independence, innovation and human orientation.

关键词： Development development integration networking orientation

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标题作者时间类型操作

核能发展国际高端论坛 International Summit on Nuclear Energy Development

2019年05月15日

会议信息

核能发展国际高端论坛 International Summit on Nuclear Energy Development

2019年05月15日

会议信息

Innovative development path of ethnomedicines: the interpretation of the path

null

期刊论文

Application of Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to the guidelinedevelopment for clinical practice with acupuncture and moxibustion

null

期刊论文

Lean Product Development—Faster, Better … Cleaner?

Geert Letens

期刊论文

The development and benefits of metformin in various diseases

期刊论文

Strategic position and development prospects of nuclear energy in China

SHEN Wenquan

期刊论文

SUSTAINABLE DEVELOPMENT OF CROP-LIVESTOCK FARMS IN AFRICA

期刊论文