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The genetic regulation of skeletal muscle development: insights from chicken studies
Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG
《农业科学与工程前沿(英文)》 2017年 第4卷 第3期 页码 295-304 doi: 10.15302/J-FASE-2017159
关键词: chicken epigenetic modification miRNAs skeletal muscle development SNP transcription factor
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Fruit ripening is a complex developmental process made up of genetically programmed physiological and biochemical activities. It culminates in desirable changes in the structural and textural properties and is governed by a complex regulatory network. Much is known about ethylene, one of the most important metabolites promoting the ripening of climacteric fruits. However, the dynamic interplay between phytohormones also plays an important part. Additional regulatory factors such as transcription factors (TFs) and epigenetic modifications also play vital role in the regulation of climacteric fruit ripening. Here, we review and evaluate the complex regulatory network comprising interactions between hormones and the action of TFs and epigenetic modifications during climacteric fruit ripening.
关键词: climacteric fruit ripening / phytohormones / TFs / epigenetic modifications
Yinglin JI, Mingyang XU, Aide WANG
《农业科学与工程前沿(英文)》 页码 314-334 doi: 10.15302/J-FASE-2021386
关键词: climacteric fruit ripening phytohormones TFs epigenetic modifications
《医学前沿(英文)》 2022年 第16卷 第2期 页码 176-184 doi: 10.1007/s11684-021-0885-y
关键词: small noncoding RNAs epigenetic inheritance paternal intergenerational inherence extracellular vesicles
The value of epigenetic markers in esophageal cancer
Xiao-Mei ZHANG, Ming-Zhou GUO,
《医学前沿(英文)》 2010年 第4卷 第4期 页码 378-384 doi: 10.1007/s11684-010-0230-3
关键词: epigenetics DNA methylation esophageal cancer dysplasia
Sustainable functionalization and modification of materials via multicomponent reactions in water
《化学科学与工程前沿(英文)》 2022年 第16卷 第9期 页码 1318-1344 doi: 10.1007/s11705-022-2150-6
关键词: materials multicomponent reactions modification functionalization water
An investigation on modification mechanism of CH
Qiang XIN, Shanghong HUANG
《结构与土木工程前沿(英文)》 2017年 第11卷 第3期 页码 293-300 doi: 10.1007/s11709-017-0403-0
关键词: low temperature coal tar pitch modification road performance
《化学科学与工程前沿(英文)》 2023年 第17卷 第8期 页码 991-1009 doi: 10.1007/s11705-022-2259-7
关键词: low dielectric constant chemical and physical modification cellulose insulating paper transformer nanomaterials.
Innate immune responses in RNA viral infection
Qian Xu, Yuting Tang, Gang Huang
《医学前沿(英文)》 2021年 第15卷 第3期 页码 333-346 doi: 10.1007/s11684-020-0776-7
关键词: innate immune viral infection intercellular signaling metabolic changes epigenetic changes
《化学科学与工程前沿(英文)》 2023年 第17卷 第12期 页码 1837-1865 doi: 10.1007/s11705-023-2347-3
Crystal modification of rifapentine using different solvents
Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 65-69 doi: 10.1007/s11705-009-0302-6
关键词: identical scanning calorimetry different comparative dissolution structure modification
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 231-241 doi: 10.1007/s11684-013-0253-7
Hepatocellular carcinoma (HCC) development is characterized by the presence of epigenetic alterations, including promoter DNA hypermethylation and post-translational modifications of histone, which profoundly affect expression of a wide repertoire of genes critical for cancer development. Emerging data suggest that deregulation of polycomb group (PcG) proteins, which are key chromatin modifiers repressing gene transcription during developmental stage, plays a causative role in oncogenesis. PcG proteins assemble into polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2) to impose the histone H3 lysine 27 trimethylation (H3K27me3) modification for repression. In this review, we will first recapitulate the mechanisms of two key epigenetic pathways: DNA methylation and histone modifications. Specifically, we will focus our discussion on the molecular roles of PcG proteins. Next, we will highlight recent findings on PcG proteins, their clinicopathological implication and their downstream molecular consequence in hepatocarcinogenesis. Last but not least, we will consider the therapeutic potential of targeting enhancer of zeste homolog 2 (EZH2) as a possible treatment for HCC. Improving our understanding on the roles of PcG proteins in hepatocarcinogenesis can benefit the development of epigenetic-based therapy.
关键词: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2)
RNA m6A modification and its function in diseases
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 481-489 doi: 10.1007/s11684-018-0654-8
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modification could be installed by m6A “writers” composed of core catalytic components (METTL3/METTL14/WTAP) and newly defined regulators and removed by m6A “erasers” (FTO and ALKBH5). The function of m6A is executed by m6A “readers” that bind to m6A directly (YTH domain-containing proteins, eIF3 and IGF2BPs) or indirectly (HNRNPA2B1). In the past few years, advances in m6A modulators (“writers,” “erasers,” and “readers”) have remarkably renewed our understanding of the function and regulation of m6A in different cells under normal or disease conditions. However, the mechanism and the regulatory network of m6A are still largely unknown. Moreover, investigations of the m6A physiological roles in human diseases are limited. In this review, we summarize the recent advances in m6A research and highlight the functional relevance and importance of m6A modification in in vitro cell lines, in physiological contexts, and in cancers.
《化学科学与工程前沿(英文)》 2022年 第16卷 第5期 页码 614-633 doi: 10.1007/s11705-021-2115-1
关键词: poly(aryl sulfone) membrane separations modification hydrophilicity water treatment
Study on Big Data-based Behavior Modification in Metro Construction
Lie-yun Ding,Sheng-yu Guo
《工程管理前沿(英文)》 2015年 第2卷 第2期 页码 131-136 doi: 10.15302/J-FEM-2015037
关键词: big data unsafe behavior behavior modification behavior-based safety (BBS) unsafe behavior rate
标题 作者 时间 类型 操作
The genetic regulation of skeletal muscle development: insights from chicken studies
Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG
期刊论文
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
期刊论文
RECENT ADVANCES IN THE REGULATION OF CLIMACTERIC FRUIT RIPENING: HORMONE, TRANSCRIPTION FACTOR AND EPIGENETIC
Yinglin JI, Mingyang XU, Aide WANG
期刊论文
environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational epigenetic
期刊论文
Sustainable functionalization and modification of materials via multicomponent reactions in water
期刊论文
Research progress on low dielectric constant modification of cellulose insulating paper for power transformers
期刊论文
Surface modification techniques of membranes to improve their antifouling characteristics: recent advancements
期刊论文
Crystal modification of rifapentine using different solvents
Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,
期刊论文
Hydrophilic modification of poly(aryl sulfone) membrane materials toward highly-efficient environmental
期刊论文