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Etiology of invasive candidosis agents in Russia: a multicenter epidemiological survey

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《医学前沿（英文）》 2018年第12卷第1期页码 84-91 doi: 10.1007/s11684-017-0612-x

摘要：

A multicenter prospective epidemiological survey on the etiologic agents of invasive candidosis was conducted in Russia in the period of 2012–2014. Samples were collected from 284 patients with invasive candidosis and Candida species isolated by culture. The species were identified by DNA sequencing and MALDI-TOF mass-spectrometry. A total of 322 isolates were recovered, in which 96% of Сandida species belonged to six major species, namely, C. albicans (43.2%), C. parapsilosis (20.2%), C. glabrata (11.5%), C. tropicalis (9.6%), C. krusei (6.2%), and C. guilliermondii (5.3%). Most Candida species were isolated from blood samples (83.23%). Notably, the prevalence rate of C. albicans reduced from 52.38% to 32.79% (2012 vs. 2014) (P=0.01) whereas that of non-C. albicans increased from 47.62% (2012) to 67.21% (2014) (P<0.01). Species distribution differed among geographical regions; specifically, the prevalence rate of C. albicans as an etiologic agent of invasive candidosis in Siberian Federal region was significantly higher than that in other Federal regions. Results indicated a shift from C. albicans to non-C. albicans. Therefore, a detailed investigation on the contributing factors and appropriate treatment of invasive candidosis is needed.

关键词： prevalence &Scy andida species invasive candidosis nosocomial etiology MALDI-TOF mass-spectrometry candidemia

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Update on Mayer–Rokitansky–Küster–Hauser syndrome

《医学前沿（英文）》 2022年第16卷第6期页码 859-872 doi: 10.1007/s11684-022-0969-3

摘要： This review presents an update of Mayer–Rokitansky–Küster–Hauser (MRKH) syndrome on its etiologic, clinical, diagnostic, psychological, therapeutic, and reproductive aspects. The etiology of MRKH syndrome remains unclear due to its intrinsic heterogeneity. Nongenetic and genetic causes that may interact during the embryonic development have been proposed with no definitive etiopathogenesis identified. The proportion of concomitant extragenital malformations varies in different studies, and the discrepancies may be explained by ethnic differences. In addition to physical examination and pelvic ultrasound, the performance of pelvic magnetic resonance imaging is crucial in detecting the presence of rudimentary uterine endometrium. MRKH syndrome has long-lasting psychological effects on patients, resulting in low esteem, poor coping strategies, depression, and anxiety symptoms. Providing psychological counseling and peer support to diagnosed patients is recommended. Proper and timely psychological intervention could significantly improve a patient’s outcome. Various nonsurgical and surgical methods have been suggested for treatment of MRKH syndrome. Due to the high success rate and minimal risk of complications, vaginal dilation has been proven to be the first-line therapy. Vaginoplasty is the second-line option for patients experiencing dilation failure. Uterine transplantation and gestational surrogacy are options for women with MRKH syndrome to achieve biological motherhood.

关键词： MRKH (Mayer–Rokitansky–Küster–Hauser) syndrome etiology clinical characteristic diagnosis treatment psychological effect

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针刀医学体系概论

朱汉章

《中国工程科学》 2006年第8卷第7期页码 1-15

摘要：

针刀医学是在中医基本理论指导下，吸收现代科技成果，包括西医学的新成果，再创造而形成的新的医学理论体系；经过30年的发展，形成了一套完整的理论体系，是中医在基本理论方面实现现代化的成功范例之一；包括四大基础理论和六大组成部分：四大基础理论是闭合性手术理论，慢性软组织损伤的病因病理学理论，骨质增生新的病因学理论，脊柱区带病因学及人体存在庞大的电生理线路的理论；六大组成部分是针刀医学病理生理学，针刀医学影像学，针刀医学手法学，针刀医学诊断学，针刀医学治疗学和针刀医学护理学；经过临床实践和深入研究，其理论不断深化，治疗技术逐渐提高，适应症范围不断扩大，形成了一门独特的医学新学科，为解决当今医学上的各种难题开辟了一条新路，在临床研究和实验研究方面取得了多项成果。

关键词：针刀医学闭合性手术脊柱区带病因学电生理线路中医现代化

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基于正交质谱的N-糖组谱揭示哈夫病潜在病原学 Article

刘思, 刘圆圆, 林佳静, 刘笔锋, 何振宇, 吴晓旻, 刘欣

《工程（英文）》 2023年第26卷第7期页码 63-73 doi: 10.1016/j.eng.2022.09.012

摘要：

食用煮熟的小龙虾可能导致哈夫病（HD），该病被认为是由不明毒素引起的，而病因尚不清楚。N-糖组的剖析将促进破译疾病的分子机制，而HD相关的糖基化从未被探索过。2019—2020年期间，本研究团队招募了来自武汉市疾病预防控制中心的90份HD患者和对照组血清样本。本文中，采用基于高通量的正交质谱对HD中血清和血清衍生的IgG的N-糖组谱进行了表征。数据显示，HD与总血清糖蛋白的核心岩藻糖基化和单半乳糖醇化升高有关。血清IgG水平是HD患者的良好指标。此外，IgG的差异半乳糖基化和唾液酸化与HD密切相关。值得注意的是，IgG1和IgG2的半乳糖基化和唾液酸化的变化具有亚类特异性。有意义的是，IgG2或IgG3/4的唾液酸化和半乳糖基化改变与HD的临床标志物密切相关。本研究表明差异化IgG N-糖基化与HD的关联，为这种罕见疾病的病因提供了新的见解。

关键词：哈夫病全血清 IgG抗体糖基化疾病病原学