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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
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《医学前沿（英文）》 2011年 第5卷 第1期 页码 94-100 doi: 10.1007/s11684-011-0116-z
Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic disease with high morbidity and mortality. Bone marrow is the traditional source of human MSC, but human term placenta appears to be an alternative and more readily available source. Here, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patients with longer duration, islet cell dysfunction, high insulin doses as well as poor glycemic control in order to evaluate the safety, efficacy and feasibility of PD-MSC treatment in type 2 diabetes (T2D). Ten patients with T2D received three intravenous infusions of PDSC, with one month interval of infusion. The total number of PDSC for each patient was (1.22–1.51) × 106/kg, with an average of 1.35 × 106/kg. All of the patients were followed up after therapy for at least 3 months. A daily mean dose of insulin used in 10 patients was decreased from 63.7?±?18.7 to 34.7?±?13.4 IU (P<0.01), and the C-peptide level was increased from 4.1?±?3.7 ng/mL to 5.6?±?3.8 ng/mL (P<0.05) respectively after therapy. In 4 of 10 responders their insulin doses reduced more than 50% after infusion. The mean levels of insulin and C-peptide at each time point in a total of 10 patients was higher after treatment (P<0.05). No fever, chills, liver damage and other side effects were reported. The renal function and cardiac function were improved after infusion. The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple, safe and effective therapeutic approach for T2D patients with islet cell dysfunction. Further large-scale, randomized and well-controlled clinical studies will be required to substantiate these observations.
New medical risks affecting obstetrics after implementation of the two-child policy in China
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《医学前沿（英文）》 2017年 第11卷 第4期 页码 570-575 doi: 10.1007/s11684-017-0552-5
China recently instituted a two-child policy in response to its aging population, declining workforce and demographic dividend, and the need to develop asocial economy. Additionally, women generally delay having a second child because of the overwhelming pressure in their lives. With the improvements in assisted fertility technologies in recent years, the number of elderly women attempting to bear children has increased. The quality of woman’s eggs and a man’s sperm declined dramatically with increasing age, leading to an increased risk of pregnancy-related complications among older women. Therefore, the types of fertility problems experienced by elderly females must be provided with considerable attention by obstetricians. This commentary article focuses on the medical problems faced by older second-child pregnant women. This work discusses their increased rates of infertility, spontaneous abortion, fetal malformation, gestational diabetes, cesarean section, placenta previa, postpartum hemorrhage, postpartum depression, and hypertensive disorders, which complicate pregnancy.
关键词： two-child policy birth defects cesarean delivery placenta previa
Zheng AO, Chengfa ZHAO, Yanmin GAN, Xiao WU, Junsong SHI, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Zicong LI
《农业科学与工程前沿（英文）》 2019年 第6卷 第1期 页码 54-60 doi: 10.15302/J-FASE-2018249
Somatic cell nuclear transfer (SCNT)-derived piglets have significantly higher stillbirth rate and postnatal mortality rate than artificial insemination (AI)-generated piglets. The question whether the low survival rate of SCNT piglets was related to birth weight, umbilical cord or placenta development was investigated. In this study, stillbirth rate, neonatal death rate, birth weight, umbilical cord status, placental parameters and placental gene expression patterns were compared between SCNT and AI piglets. Results showed that mortality rates at birth and during the neonatal stage of SCNT piglets were significantly higher than those of AI piglets. The incidence of abnormal umbilical cord in SCNT and SCNT-liveborn (SCNT-LB) piglets was significantly higher than in AI and AI-liveborn (AI-LB) piglets. Birth weight, placental weight, placental surface area and placental efficiency in SCNT and SCNT-LB piglets were significantly lower than those of AI and AI-LB piglets. Placental expression profiles of imprinting, angiopoiesis and nutrient transport-related genes were defective in SCNT-LB piglets compared with those in AI-LB piglets. Thus, the low survival rate of SCNT piglets may be associated with abnormal umbilical cord and placenta development. These characteristics may have resulted from aberrant expression of angiogenesis, nutrient transport, and imprinting-related genes in the placentas.
SARS-CoV-2 侵入因子——ACE2 和TMPRSS2 在围着床期胚胎和母胎界面存在表达 Article
陈伟,袁鹏,杨铭,严智强,孔思明,严杰,柳溪溪,陈依东,乔杰,闫丽盈
《工程（英文）》 2020年 第6卷 第10期 页码 1162-1169 doi: 10.1016/j.eng.2020.07.013
在全球肆虐的严重急性呼吸系统综合征冠状病毒2（severe acute respiratory syndrome coronavirus 2,SARS-CoV-2）导致了大量人群感染，血管紧张素转化酶2（angiotensin-converting enzyme 2, ACE2）是SARS-CoV和SARS-CoV-2的受体蛋白。然而是否存在SARS-CoV-2的垂直传播仍颇有争议。为了探讨SARS-CoV-2垂直传播的潜在风险，我们利用已发表的单细胞转录组数据观察了围着床期胚胎和母胎界面上ACE2和TMPRSS2（编码跨膜丝氨酸蛋白酶2）的转录表达情况。结果显示，ACE2和TMPRSS2在第6天（D6）围着床期胚胎的滋养外胚层（trophectoderm, TE）细胞、妊娠第8周的合胞滋养层（syncytiotrophoblast at 8 weeks of gestation, STB_8W）细胞以及妊娠第24周的绒毛外滋养层（extravillous trophoblasts at 24 weeks of gestation, EVT_24W）细胞中均存在明显的共表达现象，表明这些细胞类群可能易被SARS-CoV-2感染。在这三个细胞类群中，ACE2阳性表达细胞相对于阴性细胞在自噬和免疫相关过程中存在差异。尽管ACE2的表达水平在围着床期胚胎中没有表现出性别偏差，但是其在D6 TE、第6天围着床期胚胎的原始内胚层（D6 primitive endoderm, D6 PE）细胞以及ACE2阳性表达的STB细胞中存在明显的性别差异。这表明围着床期发育第6天以及妊娠期胚胎对SARS-CoV-2的易感性可能存在性别差异。我们的结果揭示了胚胎移植过程中，围着床期以及妊娠期胚胎面临着SARSCoV-2的潜在感染风险。
关键词： SARS-CoV-2 ACE2 垂直传播 胎盘 围着床期
标题 作者 时间 类型 操作
Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study
null
期刊论文
New medical risks affecting obstetrics after implementation of the two-child policy in China
null
期刊论文
Comparison of birth weight and umbilical and placental characteristics of cloned and artificial insemination-derived piglets
Zheng AO, Chengfa ZHAO, Yanmin GAN, Xiao WU, Junsong SHI, Enqin ZHENG, Dewu LIU, Gengyuan CAI, Zhenfang WU, Zicong LI
期刊论文
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