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2023 2

2011 1

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多模态鉴定 1

宣肺败毒方 1

巨噬细胞活化 1

巨噬细胞迁移 1

炎症 1

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Long noncoding RNA LOC646029 functions as a ceRNA to suppress ovarian cancer progression through the

《医学前沿（英文）》页码 924-938 doi: 10.1007/s11684-023-1004-z

摘要： Long noncoding RNAs (lncRNAs) play a crucial regulatory role in the development and progression of multiple cancers. However, the potential mechanism by which lncRNAs affect the recurrence and metastasis of ovarian cancer remains unclear. In the current study, the lncRNA LOC646029 was markedly downregulated in metastatic ovarian tumors compared with primary tumors. Gain- and loss-of-function assays demonstrated that LOC646029 inhibits the proliferation, invasiveness, and metastasis of ovarian cancer cells in vivo and in vitro. Moreover, the downregulation of LOC646029 in metastatic ovarian tumors was strongly correlated with poor prognosis. Mechanistically, LOC646029 served as a miR-627-3p sponge to promote the expression of Sprouty-related EVH1 domain-containing protein 1, which is necessary for suppressing tumor metastasis and inhibiting KRAS signaling. Collectively, our results demonstrated that LOC646029 is involved in the progression and metastasis of ovarian cancer, which may be a potential prognostic biomarker.

关键词： ovarian cancer lncRNA LOC646029 metastasis microRNA 627-3p SPRED1

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Spectrokinetics study of probable effects of diverse inorganic ions on bleaching of dye

Rafia AZMAT, Masooda QADRI, Fahim UDDIN

《化学科学与工程前沿（英文）》 2011年第5卷第1期页码 131-138 doi: 10.1007/s11705-010-0556-z

摘要： Toluidine blue (TB) is an important anticoagulant metachromasia molecule showing a pronounced variation in the visible spectrum due to the aggregation phenomenon and electrostatic interaction with the charged synthetic and biologic polymers. The current study describes the interactive role of diverse inorganic material ions on the bleaching of toluidine blue (tolonium chloride) (TB ) with urea in acidic and basic media using the spectrophotometric technique. The spectra of TB and urea with different cations and anions were monitored and their characteristic features are presented here. The negative effect of added cations on reduction may be the result of altered electron pathways which led to suppression of the reduction/bleaching of TB, while a slight decrease in dye reduction by added anions may be due to the scavenging of the OH* radical. It has been observed in the case of Co that in addition to the electron-transfer reaction, other processes like layer and precipitate formation also appear to be taking place. The dye bleaching process followed pseudo first order kinetics with respect to TB, urea, and H ion, whereas significant decoloration in the presence of urea proved that reductants control the redox reaction. No decoloration in acidic medium with diverse ions was seen compared to alkaline media, showing that water pH played an important role in the bleaching of dye. The reduction/bleaching of dye was investigated at different temperatures, and energy parameters were evaluated for a TB -Urea reaction, including the energy of activation ( = 39.60 kJ·mol ), enthalpy of activation (? = 34?kJ·mol ), entropy of activation (? = 146.5 kJ mol ·K ), and free energy of activation (ΔG* = -52.35 kJ·mol ). A mechanism of interaction of diverse ions in dye bleaching and a mechanism of reduction based on the above findings is proposed.

关键词： TB diverse ions suppress decoloration

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零相频下离子导体的焦耳加热及其电解反应抑制 Letter

石磊, 韩宗益, 冯逸轩, 张长庚, 张祺, 朱贺, 朱世平

《工程（英文）》 2023年第25卷第6期页码 138-143 doi: 10.1016/j.eng.2022.03.004

摘要：

It is well known that heat is generated when an electric current passes through an electrical conductor. While various applications in our daily lives and industries utilize the heating of electronic conductors, little attention has been paid to the potential of ionic conductors for heating purposes. This is because of the “inevitable” electrochemical reactions, which can result in unwanted electrolysis of conductors, corrosion of electrodes, and surface fouling. This paper reports the Joule heating of ionic conductors without electrochemical reactions. Electricity with a zero-phase frequency is employed to suppress the electrolysis of ionic conductors at high voltages. Demonstrations with various ionic conductors, both liquids and solids, show highly efficient energy conversion free of electrochemical reactions. This heating method is simple, direct, fast, clean, and uniform, and it has great potential in numerous industrial and household applications.

关键词： Joule heating Ionic conductors Electrolytes Zero-phase frequency Electrochemical corrosion

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基于转录组学及多尺度生物测定多模态鉴定宣肺败毒方抑制巨噬细胞免疫反应的活性成分 Article

赵璐, 刘豪, 王迎超, 王书芳, 荀得金, 王毅, 程翼宇, 张伯礼

《工程（英文）》 2023年第20卷第1期页码 63-76 doi: 10.1016/j.eng.2021.09.007

摘要：

宣肺败毒方（XFBD）是一种临床用于治疗新型冠状病毒肺炎（COVID-19）病患的中药方剂，在临床实践中表现出了显著的疗效，但对其潜在的药理学机制尚不清楚。本研究结合网络药理学、转录组学和多模型系统生物测定等综合研究方法，研究了XFBD生物活性物质及其药理作用机制。通过高分辨质谱与分子网络相结合，对XFBD中的主要活性物质进行了分析，共鉴定或初步鉴定了104种化合物，包括黄酮类、萜类、羧酸类和其他类型的成分。基于所鉴定的XFBD化学组分，开展了网络药理学分析并将炎症相关通路确定为主要靶点。在脂多糖诱导的急性炎症小鼠模型中，XFBD明显减轻了肺部炎症，降低了血清促炎细胞因子水平。转录组学分析表明，经XFBD治疗后，与巨噬细胞功能相关的基因表达水平发生改变。在巨噬细胞细胞系和斑马鱼创伤模型中，XFBD对巨噬细胞的激活和迁移均有很强的抑制作用。最终，通过多模型系统筛选，发现XFBD中虎杖、芦根、化橘红显著下调巨噬细胞活化，虎杖苷、异甘草苷、毛蕊花糖苷为活性化合物；青蒿和麻黄显著抑制内源性巨噬细胞迁移，麻黄碱、白术内酯和山奈酚为活性化合物。综上所述，本研究通过多模态方法研究了XFBD调节炎症的活性成分以及相关药理学机制，从而为XFBD的临床疗效提供了生物学例证。

关键词：炎症巨噬细胞活化巨噬细胞迁移多模态鉴定宣肺败毒方