Search | Engineering

订阅投稿

首页工程期刊工程焦点工程成就工程前沿关于我们 English

资源类型

期刊论文 15

会议视频 1

年份

2023 5

2022 2

2021 2

2019 1

2018 1

2014 2

2007 1

2002 1

2000 1

展开︾

关键词

N-聚糖模型 1

Kdn 1

N-糖基化 1

N-聚糖 1

Windows'95 1

丙氨酸转移酶 1

亲水相互作用液相色谱法 1

信息处理 1

信息技术 1

傅立叶红外光谱 1

全基因组关联研究 1

全尺寸 1

共热解 1

前列腺特异性抗原 1

前列腺癌 1

加速湿热老化 1

助燃剂 1

协同发展 1

双抗原 1

展开︾

检索范围：

排序：展示方式：

TG-MS研究生物质组分与聚乙烯共热解特性

范洪刚,顾菁,王亚琢,袁浩然,何明阳,孙富安

《中国工程科学》 2018年第20卷第3期页码 102-108 doi: 10.15302/J-SSCAE-2018.03.015

摘要：

为了探索生物质主要组分在与塑料共热解过程中的协同效应和小分子气体产物的变化规律，笔者采用热重-质谱联用（TG-MS）技术研究纤维素、木聚糖纤维素热解的小分子产物中H2O和CO2的产量增大；木聚糖和聚乙烯在共热解过程中会促进对方分解，H₂O，CH₄，H₂和C₂

关键词：纤维素木聚糖木质素聚乙烯共热解

HTML PDF 收藏

多文种不同编辑方向的Windows´95处理平台的设计与实现

吾守尔·斯拉木,伊力哈木·牙生

《中国工程科学》 2000年第2卷第2期页码 56-59

摘要：

文章叙述了具有不同编辑方向的维、哈、阿、汉和英多文种信息处理的Windows´95平台开发与应用，不等宽民文信息处理在Windows环境中面临的问题及其解决方法，以及民文显示技术、民文处理机制及其创新点。

关键词：多文种 Windows'95 信息处理零宽度扩充编码民文处理系统

HTML PDF 收藏

碱处理对桉木纤维挤压结合机理的影响

彭万喜,林芝,李年存

《中国工程科学》 2014年第16卷第4期页码 64-68

摘要：

采用桉木纤维为原料，探讨碱处理对板材挤压结合机理的影响。结果表明：碱处理对木质素、半纤维素都有不同程度的降解作用；在热压制板过程中，经过降解作用的木材成分经适当的热压工艺能够发生聚合反应从而粘合成板；强碱（NaOH）对桉木纤维的影响大于弱碱溶液（Na2CO3），且处理时间为10 h 较适宜；碱处理过程产生的活性羟基，热压后可以缔合形成氢键，增加了纤维之间的结合力，有利于桉木纤维自身粘合成板。

关键词：桉木纤维碱处理傅立叶红外光谱扫描电子显微镜（SEM）

HTML PDF 收藏

助燃剂对木垛火燃烧特性影响研究

张小芹,宗若雯,方廷勇,王荣辉,廖光煊

《中国工程科学》 2007年第9卷第2期页码 90-97

摘要：

采用木垛火作为火源，比较添加与未添加助燃剂两种情况下其燃烧特性，研究助燃剂对可燃物燃烧特性的影响。

关键词：木垛助燃剂全尺寸燃烧特性数值模拟

HTML PDF 收藏

可去除染料——N-聚糖多方法深入分析中的缺失环节 Article

Samanta Cajic, René Hennig, Valerian Grote, Udo Reichl, Erdmann Rapp

《工程（英文）》 2023年第26卷第7期页码 132-150 doi: https://doi.org/10.1016/j.eng.2023.02.016

摘要：

As the roles of glycans in health and disease continue to be unraveled, it is becoming apparent that glycans' immense complexity cannot be ignored. To fully delineate glycan structures, we developed an integrative approach combining a set of cost-effective, widespread, and easy-to-handle analytical methods. The key feature of our workflow is the exploitation of a removable fluorescent label—exemplified by 9-fluorenylmethyl chloroformate (Fmoc)—to bridge the gap between diverse glycoanalytical methods, especially multiplexed capillary gel electrophoresis with laser-induced fluorescence detection (xCGE-LIF) and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Through the detailed structural analysis of selected, dauntingly complex N-glycans from chicken ovalbumin, horse serum, and bovine transferrin, we illustrate the capabilities of the presented strategy. Moreover, this approach "visualizes" N-glycans that have been difficult to identify thus far—such as the sulfated glycans on human immunoglobulin A—including minute changes in glycan structures, potentially providing useful new targets for biomarker discovery.

关键词：糖蛋白 N-聚糖可逆标签亲水相互作用液相色谱法毛细管凝胶电泳质谱法

HTML PDF 收藏

血清N-聚糖生物标志物诊断ALT水平正常慢性乙型肝炎患者显著肝纤维化和肝硬化的临床意义 Article

王林, 刘艺琪, 顾启馨, 张驰, 徐蕾, 王蕾, 陈翠英, 刘学恩, 赵鸿, 庄辉

《工程（英文）》 2023年第26卷第7期页码 151-158 doi: 10.1016/j.eng.2023.03.008

摘要：

本研究目的是探讨血清N-聚糖模型在285例丙氨酸转移酶（alanine aminotransferase, ALT）水平正常应用基于DNA测序仪的荧光糖电泳技术检测患者血清N-聚糖图谱，每例患者的血清样本中共鉴定出9个N-聚糖峰。），并比较血清N-聚糖模型和其他纤维化标志物的诊断效能。在诊断肝硬化（≥F5）时，血清N-聚糖RF-B模型的AUROC为0.97，与肝组织活检的符合率为88.94%。在ALT水平正常的慢性乙肝患者中，血清N-聚糖模型可作为诊断显著肝纤维化或肝硬化的潜在生物标志物。

关键词：肝纤维化慢性乙型肝炎血清N-聚糖 N-聚糖模型丙氨酸转移酶

HTML PDF 收藏

对格尔木市水问题的思考

孙雪涛

《中国工程科学》 2002年第4卷第3期页码 32-35

摘要：

在气候干旱的内陆区，水资源如何配置是城市各项事业首要考虑的问题。格尔木市是西北地区的新兴城市之一，通过对格尔木市水资源开发利用与城市发展定位关系的研究和分析，认为其用水方式粗放，用水效率低，水资源紧缺，将会成为正在高速发展的格尔木市的制约因素，未来发展如不慎重用水，后果不堪设想。

关键词：格尔木市水资源发展模式

HTML PDF 收藏

人类蛋白质N-糖基化的十二年全基因组关联研究 Review

Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko

《工程（英文）》 2023年第26卷第7期页码 17-31 doi: 10.1016/j.eng.2023.03.013

摘要：

Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycans. Glycosylation influences the physical and chemical properties of proteins, as well as their biological functions. Unsurprisingly, alterations in protein glycosylation have been implicated in a growing number of human diseases, and glycans are increasingly being considered as potential therapeutic targets, an essential part of therapeutics, and biomarkers. Although glycosylation pathways are biochemically well-studied, little is known about the networks of genes that guide the cell- and tissue-specific regulation of these biochemical reactions in humans in vivo. The lack of a detailed understanding of the mechanisms regulating glycome variation and linking the glycome to human health and disease is slowing progress in clinical applications of human glycobiology. Two of the tools that can provide much sought-after knowledge of human in vivo glycobiology are human genetics and genomics, which offer a powerful data-driven agnostic approach for dissecting the biology of complex traits. This review summarizes the current state of human populational glycogenomics. In Section 1, we provide a brief overview of the N-glycan's structural organization, and in Section 2, we give a description of the major blood plasma glycoproteins. Next, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylation genome-wide association studies (GWASs) that provide novel knowledge of the genetic regulation of the populational variation of glycosylation. Until now, such studies have been limited to an analysis of the human blood plasma N-glycome and the N-glycosylation of immunoglobulin G and transferrin. While these three glycomes make up a rather limited set compared with the enormous multitude of glycomes of different tissues and glycoproteins, the study of these three does allow for powerful analysis and generalization. Finally, in Section 4, we turn to genes in the established loci, paying particular attention to genes with strong support in Section 5. At the end of the review, in Sections 6 and 7, we describe special cases of interest in light of new discoveries, focusing on possible mechanisms of action and biological targets of genetic variation that have been implicated in human protein N-glycosylation.

关键词：糖组学聚糖 N-糖基化基因组学遗传学全基因组关联研究

HTML PDF 收藏

淀粉基API胶合木胶接结构破坏模式及失效机理

时君友,徐文彪,王淑敏

《中国工程科学》 2014年第16卷第4期页码 40-44

摘要：

以淀粉基水性高分子异氰酸酯（API）胶合木胶接结构为研究对象，以胶接的压缩剪切强度为评估指标，通过加速湿热老化试验对胶接结构的破坏模式和失效机理进行了研究

关键词：胶接结构加速湿热老化断裂性质破坏模式

HTML PDF 收藏

工业互联网安全技术发展研究

董悦,王志勤,田慧蓉,李姗,秦国英,吾守尔·斯拉木

《中国工程科学》 2021年第23卷第2期页码 65-73 doi: 10.15302/J-SSCAE-2021.02.009

摘要：

随着云计算、大数据等新一代信息技术与传统工业运营技术的深度融合，工业互联网已成为工业企业数字化转型升级的新动能；与此同时工业互联网安全问题日趋凸显，提升工业互联网安全技术保障能力成为我国工业互联网高质量发展的前提和保障。为深入了解我国工业互联网安全技术的发展情况，本文研判了我国工业互联网的发展需求，系统梳理了工业互联网安全防护技术、安全评测技术、安全监测技术的发展现状，剖析了工业互联网安全技术的发展趋势、技术难点和面临的挑战，提出了工业互联网安全关键技术的攻关路径。研究建议，工业互联网安全技术需结合工业特点及场景，开展定制化服务；紧密融合大数据、人工智能等新技术，实现主动防御；打造内生安全能力，助力工业互联网安全建设，推动我国工业互联网安全健康发展。

关键词：工业互联网安全，安全防护技术，安全评测技术，安全监测技术

HTML PDF 收藏

工业互联网设备的网络安全管理与防护研究

马娟,于广琛,柯皓仁,杨冬梅,吾守尔·斯拉木

《中国工程科学》 2021年第23卷第2期页码 81-87 doi: 10.15302/J-SSCAE-2021.02.011

摘要：

新一代信息通信技术与工业体系深度融合，工业互联网推动“人、机、物”的泛在深度互联和全面感知；工业互联网设备的网络化、数字化、智能化应用不断泛化，设备自身网络安全设计、应用过程管理与防护成为关注重点。本文从工业互联网设备的安全防护视角出发，明晰了工业互联网设备的内涵、防护范畴及需求，梳理了国内外工业互联网在安全监管和审查、安全检测认证等方面的发展现状；结合工业互联网设备的网络安全相关实践，剖析了我国工业互联网设备网络安全面临的问题。本文论证了我国工业互联网设备网络安全管理与防护的具体实施路径，并提出发展建议：从国家层面完善工业互联网设备的网络安全准入机制，建立设备网络安全检测认证体系，促进设备的网络安全架构研究和工程应用，强化设备的网络安全风险监测感知。

关键词：工业互联网设备网络安全管理防护认证

HTML PDF 收藏

智简无线网络理论与技术 Editorial

张平1,彭木根1,崔曙光2,张朝阳3,毛国强4,全智5,Tony Q. S. QUEK6,荣波7

《信息与电子工程前沿（英文）》 2022年第23卷第1期页码 1-4 doi: 10.1631/FITEE.2210000

摘要： With the acceleration of a new round of global scientific, technological, and industrial revolution, the next generation of information and communication technology, i.e., 6G, will inject new momentum into industry transformation and upgrad-ing, as well as into economic innovation and development. This will subsequently promote a global industrial integration. Wireless communication will be ubiquitous in all areas of future society, supporting novel applications with various performance requirements, such as immersive- or interactive-experience applications requiring a large bandwidth, autonomous driving and vehicle-to-everything applications requiring ultra-high reliability and ultra-low latency, and applications for industrial Internet requiring massive machine-type connectivity. Facing the challenges of the post-Moore and post-pandemic era, wireless communication needs breakthroughs in network architecture to improve the intelligence, security, robustness, bandwidth, and heterogeneity. With this background, several important tendencies have emerged in the development of 6G wireless communications: 1. Future wireless networks will evolve from “human-to-human” communications into intelligent “human-to-machine” communications. In addition to enabling communications among humans, future wireless networks will be able to support close connections among humans and machines. The behavior and intent of humans will be sensed and communicated to machines that will accordingly adjust their operations. Typical scenarios include smart building, intelligent transportation, mixed reality (MR), and others. 2. Network nodes will evolve from carrying out only traditional communications to carrying out communication, sensing, computation, management, and caching in an integrated manner. To meet the diverse service requirements of mobile MR, intelligent transportation, industrial Internet of Things, and other areas, future networks will possess multiple functionalities. For example, by sensing human head position, pre-caching necessary content, and rendering high-quality images, network nodes can provide fully immersive MR experiences. In addition, with artificial intelligence (AI), network nodes can manage multi-dimensional resources in an on-demand fashion, where intent-driven network management and control can be realized. 3. Network architecture will focus on collaborations between the cloud and the network edge, which will become more heterogenous. To shorten latency and alleviate the backhaul/fronthaul burden, the network edge must collaborate with the cloud. The first method of collaboration is that the cloud finishes AI model training and then deploys AI models into the network edge, which supports the so-called edge intelligence. In the second method, users demanding high throughput are served via a cloud radio access mode, while users requiring ultra-low latency can benefit from edge computation and caching. As for architecture heterogeneity, future networks are envisioned to incorporate unmanned aerial vehicle (UAV) networks, satellite communica-tion networks, and dense cellular networks, bringing three-dimensional and hierarchical network coverage. In short, the evolution of existing 5G technolo-gies and the development of 6G need to address more stringent and diverse application scenarios, a more strict energy constraint, and the orchestration of multi-dimensional resources. These challenges call for an intellicise wireless network operation paradigm, where “intellicise” is a new adjective that we coin, standing for intelligence-endogenous and primitive-concise. Built upon the integration of AI and next-generation networking technologies, an intellicise wireless network continually explores and exploits new intelligent primitives, e.g., semantic base (Seb) in semantic communications, proactively takes sys-tematic entropy reduction as the global optimization objective, adaptively reshapes the core models of information systems, and ultimately endows itself with endogenous intelligence and primitive conciseness. In this context, the journal has organized a special feature on the theory and techniques for intellicise wireless networks. This special feature covers information theory, architecture design, and intellicise wireless networks for achieving air-space-ground-sea integration, resource management, hardware testbeds and platforms, as well as related applications. In addition, this feature is intended to provide a review of advancements and future research directions in the research field of intellicise wireless networks. After a rigorous review process, six papers have been selected for this feature, including one review article and five research articles.

HTML PDF 收藏

羊种布鲁氏菌双抗原纳米结合疫苗的生物合成与免疫效果评估 Article

黄竞, 王玉飞, 王康丰, 李淑磊, 孙鹏, 郭艳, 刘建凯, 杨瑞馥, 曾明, 潘超, 王恒樑, 朱力

《工程（英文）》 2023年第29卷第10期页码 95-109 doi: 10.1016/j.eng.2023.04.007

摘要：首先，我们使用蛋白-聚糖生物偶联技术将抗原多糖与外膜蛋白Omp19共价偶联，然后通过SpyTag/SpyCatcher系统将其装载到纳米载体上。

关键词：蛋白-聚糖偶联技术（PGCT）双抗原纳米结合疫苗羊种布鲁氏菌

HTML PDF 收藏

藏北高原草地生态治理与畜牧业协同发展模式研究

干珠扎布,胡国铮,高清竹,江村旺扎,旦久罗布,参木友,巴桑旺堆,杨富裕,魏学红,杨永平

《中国工程科学》 2019年第21卷第5期页码 93-98 doi: 10.15302/J-SSCAE-2019.05.013

摘要：

藏北高原是我国重要的生态安全屏障和高原特色畜牧业基地，而高寒草地退化严重制约着其生态和生产功能，给生态保护和畜牧业发展带来了挑战。本文在深入分析藏北高原生态治理与畜牧业发展状况的基础上，探讨了藏北高寒草地生态与生产功能的主要影响因素，提出了藏北高原草地生态治理与畜牧业协同发展的模式体系。研究表明，通过草地生态恢复、优化放牧管理方式、人工牧草种植、低海拔农区种草高海拔牧区养畜的“低草高牧”模式、冬季半舍饲养殖等一系列措施，能够推进高寒草地生态功能提升、促进草地畜牧业转型升级，实现“保护中发展”与“发展中保护”。相关研究将为治边稳藏、保障国家生态安全、增加牧民收入提供战略引导和科技支撑。

关键词：藏北高原生态修复草地畜牧业协同发展

HTML PDF 收藏

人体前列腺特异性抗原携带含酮基-脱氧壬酮糖酸的N-聚糖 Article

Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer

《工程（英文）》 2023年第26卷第7期页码 119-131 doi: 10.1016/j.eng.2023.02.009

摘要：

Ketodeoxynononic acid (Kdn) is a rather uncommon class of sialic acid in mammals. However, associations have been found between elevated concentrations of free or conjugated Kdn in relation to human cancer progression. Hitherto, there has been a lack of conclusive evidence that Kdn occurs on (specific) human glycoproteins (conjugated Kdn). Here, we report for the first time that Kdn is expressed on prostate-specific antigen (PSA) N-linked glycans derived from human seminal plasma and urine. Interestingly, Kdn was found only in an α2,3-linkage configuration on an antennary galactose, indicating a highly specific biosynthesis. This unusual glycosylation feature was also identified in a urinary PSA cohort in relation to prostate cancer (PCa), although no differences were found between PCa and non-PCa patients. Further research is needed to investigate the occurrence, biosynthesis, biological role, and biomarker potential of both free and conjugated Kdn in humans.

关键词：酮基-脱氧壬酮糖酸 Kdn 糖基化前列腺癌前列腺特异性抗原