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《医学前沿(英文)》 2015年 第9卷 第1期 页码 46-56 doi: 10.1007/s11684-015-0375-1
Sickle cell disease (SCD) is an inherited disorder of hemoglobin in which the abnormal hemoglobin S polymerizes when deoxygenated. This polymerization of hemoglobin S not only results in hemolysis and vaso-occlusion but also precipitates inflammation, oxidative stress and chronic organ dysfunction. Oxidative stress is increasingly recognized as an important intermediate in these pathophysiological processes and is therefore an important target for therapeutic intervention. The transcription factor nuclear erythroid derived- 2 related factor 2 (Nrf2) controls the expression of anti-oxidant enzymes and is emerging as a protein whose function can be exploited with therapeutic intent. This review article is focused on triterpenoids that activate Nrf2, and their potential for reducing oxidative stress in SCD as an approach to prevent organ dysfunction associated with this disease. A brief overview of oxidative stress in the clinical context of SCD is accompanied by a discussion of several pathophysiological mechanisms contributing to oxidative stress. Finally, these mechanisms are then related to current management strategies in SCD that are either utilized currently or under evaluation. The article concludes with a perspective on the potential of the various therapeutic interventions to reduce oxidative stress and morbidity associated with SCD.
关键词: oxidative stress Nrf2 triterpenoids sickle cell disease vaso-occlusion CDDO-Me
《化学科学与工程前沿(英文)》 2023年 第17卷 第3期 页码 314-325 doi: 10.1007/s11705-022-2219-2
关键词: acceptorless alcohol dehydrogenation η5-C5Me5-Co metal–ligand cooperation theoretical calculation
知识推送系统中一种基于多分类径向基神经网络的知识匹配方法 Research Articles
张树有,顾叶,伊国栋,王自立
《信息与电子工程前沿(英文)》 2020年 第21卷 第7期 页码 963-1118 doi: 10.1631/FITEE.1900057
标题 作者 时间 类型 操作
Triterpenoid inducers of Nrf2 signaling as potential therapeutic agents in sickle cell disease: a review
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期刊论文
Effects of ancillary ligands in acceptorless benzyl alcohol dehydrogenation mediated by phosphine-free cobalt complexes
期刊论文