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期刊论文 3

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2018 1

2008 1

关键词

遥感，地理信息系统，水土评估工具，水文模拟，SUFI-2，GLUE，ParaSol，产沙量 1

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Therapeutic effect of medical glue combined with the great omentum in severe tunica muscularis injury

REN Peitu, LU Baochun, RUAN Xinxian, CHEN Zhiliang, MA Yuliang, FU Hong

《医学前沿（英文）》 2008年 第2卷 第2期   页码 143-146 doi: 10.1007/s11684-008-0027-9

摘要： Twenty-seven patients with severe colon trauma treated in the Shaoxing People’s Hospital from 1995 to 2006 were retrospectively analyzed. The patients with severe tunica muscularis injury were treated by medical glue combined with the greater omentum during operations. The initial result was encouraging. All patients were cured with no anastomotic leakage or abscess. Therefore, reasonable use of medical glue combined with the greater omentum can not only improve the curative rate but also reduces postoperative complications for patients with colon injury.

关键词： abscess     initial     muscularis     anastomotic     medical    

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Discovery of small molecule degraders for modulating cell cycle

《医学前沿（英文）》   页码 823-854 doi: 10.1007/s11684-023-1027-5

摘要： The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

关键词： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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恒河流域水文模型SWAT模型标定技术的比较

Nikita Shivhare,Prabhat Kumar Singh Dikshit,Shyam Bihari Dwivedi

《工程（英文）》 2018年 第4卷 第5期   页码 643-652 doi: 10.1016/j.eng.2018.08.012

摘要：

The Ganga河流是印度最长的河流，人为活动和气候变化极为严峻，特别是在瓦拉纳西地区。预期的气候变化和人口增长将进一步阻碍水的有效利用。在这项研究中，将水文模型应用到北方邦南部15 161.612 km 2 恒河流域的土壤和水评估工具（SWAT）模型中。这项研究的主要目标是：①为了测试SWAT模型在预测径流和泥沙产量方面的执行性和适用性；和②比较和确定三种流行算法中的最佳校准算法。

关键词： 遥感，地理信息系统，水土评估工具，水文模拟，SUFI-2，GLUE，ParaSol，产沙量    

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标题 作者 时间 类型 操作

Therapeutic effect of medical glue combined with the great omentum in severe tunica muscularis injury

REN Peitu, LU Baochun, RUAN Xinxian, CHEN Zhiliang, MA Yuliang, FU Hong

期刊论文

Discovery of small molecule degraders for modulating cell cycle

期刊论文

恒河流域水文模型SWAT模型标定技术的比较

Nikita Shivhare,Prabhat Kumar Singh Dikshit,Shyam Bihari Dwivedi

期刊论文