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孙学用
《中国工程科学》 2007年 第9卷 第12期 页码 94-96
Fabrication of MIL-100(Fe)@SiO
Yinlong Hu,Shuang Zheng,Fumin Zhang
《化学科学与工程前沿(英文)》 2016年 第10卷 第4期 页码 534-541 doi: 10.1007/s11705-016-1596-9
关键词: metal-organic frameworks heterogeneous catalysis magnetically recoverable catalysts core-shell structure acetalization
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《医学前沿(英文)》 2016年 第10卷 第4期 页码 444-450 doi: 10.1007/s11684-016-0471-x
The incidence rate of pancreatic neuroendocrine neoplasms (pNENs) has increased rapidly in recent years. However, the clinicopathological characteristics of pNENs are poorly understood. Medical records of patients who underwent surgery and were confirmed as pNENs by pathological examination from January 2003 to February 2015 in Qilu Hospital were reviewed retrospectively. A total of 100 patients, 36 males and 64 females, were included with a mean operation age of 46.26±13.41 years. Among the 100 cases, 76 had insulinomas and 24 had non-functional pNENs. Tumor size ranged from 0.5 cm to 9 cm, and the mean size was 2.20±1.40 cm. The percentages of TNM stages I, II, III, and IV tumors were 89.0%, 8.0%, 0.0%, and 3.0%, respectively. Based on the WHO classification, pNENs were classified into three grades: G1, G2, and G3. G1, G2, and G3 tumors were confirmed in 72.9%, 23.7%, and 3.4% patients, respectively. The positive rates of CgA and Syn immunohistochemical staining were 94.5% (69/73) and 100% (74/74), respectively. Compared with insulinoma, non-functional pNENs have larger tumor sizes, more advanced TNM staging, a higher Ki-67 index, and a higher rate of liver metastasis (P<0.05). In conclusion, pNENs are heterogeneous tumors with varying clinical manifestations, diverse tumor biological characteristics, and different prognoses. Non-functional pNENs present a more aggressive behavioral model and have poorer prognosis than functional pNENs.
关键词: pancreatic neuroendocrine neoplasms clinicopathological characteristic Ki-67 liver metastasis outcomes
Regulatory mechanism and functional analysis of
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《医学前沿(英文)》 2017年 第11卷 第1期 页码 87-96 doi: 10.1007/s11684-016-0469-4
S100A9, a calcium-binding protein, participates in the inflammatory process and development of various tumors, thus attracting much attention in the field of cancer biology. This study aimed to investigate the regulatory mechanism of and its function involvement in APL. We used real-time quantitative PCR to determine whether PML/RARα affects the expression of in NB4 and PR9 cells upon ATRA treatment. ChIP-based PCR and dual-luciferase reporter assay system were used to detect how PML/RARα and PU.1 regulate promoter activity. CCK-8 assay and flow cytometry were employed to observe the viability and apoptosis of NB4 cells when was overexpressed. Results showed that was an ATRA-responsive gene, and PML/RARα was necessary for the ATRA-induced expression of in APL cells. In addition, PU.1 could bind to the promoter of , especially when treated with ATRA in NB4 cells, and promote its activity. More importantly, overexpression of induced the apoptosis of NB4 cells and inhibited cell growth. Collectively, our data indicated that PML/RARα and PU.1 were necessary for the ATRA-induced expression of in APL cells. Furthermore, promoted apoptosis in APL cells and affected cell growth.
关键词: S100A9 S100A9 PU.1 PML/RARα ATRA APL
《医学前沿(英文)》 2022年 第16卷 第1期 页码 126-138 doi: 10.1007/s11684-021-0897-7
关键词: type 2 diabetes quality of care macrovascular complication microvascular complication treatment pattern epidemiology
Development of temperature-robust damage factor based on sensor fusion for a wind turbine structure
Jong-Woong PARK,Sung-Han SIM,Jin-Hak YI,Hyung-Jo JUNG
《结构与土木工程前沿(英文)》 2015年 第9卷 第1期 页码 42-47 doi: 10.1007/s11709-014-0285-3
关键词: sensor fusion damage detection structural health monitoring
《化学科学与工程前沿(英文)》 2023年 第17卷 第7期 页码 930-941 doi: 10.1007/s11705-023-2309-9
关键词: lignin electrospinning heterojunctions photo-Fenton catalysis wastewater remediation
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 410-422 doi: 10.1007/s11684-017-0527-6
Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion protein causes lethal hyperfibrinolysis in acute promyelocytic leukemia (APL), but the mechanism is unclear. To facilitate the investigation of regulatory association between ANXA2 and promyelocytic leukemia/retinoic acid receptor a (PML/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2 promoter with rapid amplification of 5′-cDNA ends analysis. Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2 transcripts and translational expressions of both ANXA2 and S100A10, while S100A10 transcripts remained constitutive. The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higher than that by control pSG5 vector or wild-type RARα. The overexpression of ANXA2 in U937 transfected with full-length ANXA2 cDNA was associated with increased S100A10 subunit, although S100A10 transcripts remained constitutive. The tPA-dependent initial rate of plasmin generation (IRPG) in zinc-treated U937/PR9 increased by 2.13-fold, and cell invasiveness increased by 27.6%. Antibodies against ANXA2, S100A10, or combination of both all remarkably inhibited the IRPG and invasiveness in U937/PR9 and NB4. Treatment of zinc-induced U937/PR9 or circulating APL blasts with all-trans retinoic acid (ATRA) significantly reduced cell surface ANXA2 and S100A10 and associated reductions in IRPG and invasiveness. Thus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate S100A10. Increased AIIt promoted IRPG and invasiveness, both of which were partly abolished by antibodies against ANXA2 and S100A10 or by ATRA.
关键词: annexin A2-S100A10 heterotetramer PML/RARα fusion protein plasmin cell invasion acute promyelocytic leukemia
石照耀,费业泰,谢华锟
《中国工程科学》 2003年 第5卷 第9期 页码 13-17
全面概述了过去100年齿轮测量技术的发展历程,给出了6件标志性事情;着重论述了测量原理的演变、实现测量原理技术方式的发展以及测量结果的表述与利用;介绍了当今CNC齿轮测量中心的原理、组成和特点;结合
Two-dimensional SnS2 nanosheets on Prussian blue template for high performance sodium ion batteries
Sim, Kakui Ma, Zhixiang Huang, Shaozhuan Huang, Ye Wang, Huiying Yang
《化学科学与工程前沿(英文)》 2019年 第13卷 第3期 页码 493-500 doi: 10.1007/s11705-019-1826-z
关键词: Prussian blue carbon nanocubes tin disulfide sodium ion batteries
HRT波方法准确预测强震时空强的可行性及其汶川8级等强震的震例
赵玉林,钱复业
《中国工程科学》 2009年 第11卷 第6期 页码 111-122
关键词: “黑箱”与HRT 波预测模型 “PS -100”HRT 波接收网站 波动前兆的发现及其规律性 HRT 波模型的实用性
Sustainability of metal recovery from E-waste
Biswajit Debnath, Ranjana Chowdhury, Sadhan Kumar Ghosh
《环境科学与工程前沿(英文)》 2018年 第12卷 第6期 doi: 10.1007/s11783-018-1044-9
Metal recovery techniques from electronic waste reported in literature. Metal recovery processes followed in Industries from electronic waste. Sustainability analysis of metal recovery processes from electronic waste.
关键词: E-waste Metal recovery Metal Recovery from E-waste (MREW) Sustainability
Lamb wave propagation modeling for structure health monitoring
Xiaoyue ZHANG, Shenfang YUAN, Tong HAO
《机械工程前沿(英文)》 2009年 第4卷 第3期 页码 326-331 doi: 10.1007/s11465-009-0045-6
关键词: Lamb wave modeling LISA/SIM theory finite difference equation finite element
《环境科学与工程前沿(英文)》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1679-z
● Heavy metals and organic toxins may persist in legacy sites for a long time.
关键词: E-waste Human health risk Organ risk Heavy metal toxicity PBDE PCDD/F
标题 作者 时间 类型 操作
Analysis of 100 consecutive cases of resectable pancreatic neuroendocrine neoplasms: clinicopathological
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期刊论文
quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM
期刊论文
Development of temperature-robust damage factor based on sensor fusion for a wind turbine structure
Jong-Woong PARK,Sung-Han SIM,Jin-Hak YI,Hyung-Jo JUNG
期刊论文
Lignin-based electrospun nanofiber membrane decorated with photo-Fenton Ag@MIF-100(Fe) heterojunctions
期刊论文
Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent
null
期刊论文
Two-dimensional SnS2 nanosheets on Prussian blue template for high performance sodium ion batteries
Sim, Kakui Ma, Zhixiang Huang, Shaozhuan Huang, Ye Wang, Huiying Yang
期刊论文
Sustainability of metal recovery from E-waste
Biswajit Debnath, Ranjana Chowdhury, Sadhan Kumar Ghosh
期刊论文
Lamb wave propagation modeling for structure health monitoring
Xiaoyue ZHANG, Shenfang YUAN, Tong HAO
期刊论文