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《工程管理前沿(英文)》 页码 67-81 doi: 10.1007/s42524-022-0240-2
关键词: logistics network design post-disruption response strategy two-stage stochastic programming conditional value at risk robust constraint
Modeling of the resilient supply chain system from a perspective of production design changes
《工程管理前沿(英文)》 页码 96-106 doi: 10.1007/s42524-022-0235-z
关键词: resilient supply chain supply chain disruption domain modeling product design changes
Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in
LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan
《环境科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 433-440 doi: 10.1007/s11783-013-0594-0
关键词: sewage sludge in vitro bioassay endocrine disruption dioxin-like effect
Shen Huang,Xudong Feng,Chun Li
《化学科学与工程前沿(英文)》 2015年 第9卷 第4期 页码 501-510 doi: 10.1007/s11705-015-1544-0
关键词: β-glucuronidase glycyrrhetic acid monoglucuronide cell disruption purification chromatography
CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells
null
《医学前沿(英文)》 2017年 第11卷 第4期 页码 554-562 doi: 10.1007/s11684-017-0543-6
T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advanced refractory B cell malignancy. However, many challenges remain in extending its application toward the treatment of solid tumors. The immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-T efficacy. One negative regulator of T cell activity is lymphocyte activation gene-3 (LAG-3). We successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using CRISPR-Cas9 mediated gene editing and found that the viability and immune phenotype were not dramatically changed during in vitro culture. LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity in cell culture and in murine xenograft model, which is comparable to standard CAR-T cells. Our study demonstrates an efficient approach to silence immune checkpoint in CAR-T cells via gene editing.
关键词: CAR-T CRISPR-Cas9 LAG-3
Wan N. A. Kadir, Man K. Lam, Yoshimitsu Uemura, Jun W. Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee
《化学科学与工程前沿(英文)》 2021年 第15卷 第5期 页码 1257-1268 doi: 10.1007/s11705-020-2015-9
航空公司不正常航班管理——模型和解决方法综述 Review
苏艺, 谢可欣, 王洪建, 梁哲, Wanpracha Art Chaovalitwongse, Panos M. Pardalos
《工程(英文)》 2021年 第7卷 第4期 页码 435-447 doi: 10.1016/j.eng.2020.08.021
航班的正常运行可能会受到各种不可预测因素的影响,导致如机场关闭、临时飞机维护等不正常航班情况发生。当不正常航班产生时,航空公司运行控制中心会采取多种方法来调整资源(包括航班时刻、飞机和机组等)的分配并重新安排旅客以实现航班计划的恢复。本文首先介绍了不正常航班生成的可能场景和一系列常见的恢复手段,接着回顾了飞机路径恢复、机组恢复和多资源整合恢复的基本模型和相关扩展研究,旨在为航空公司实际运行中不同的恢复场景提供合适的模型和方法。此外,本文还对相关课题的未来研究方向提出了建议。
Metro train rescheduling by adding backup trains under disrupted scenarios
Jiateng YIN, Yihui WANG, Tao TANG, Jing XUN, Shuai SU
《工程管理前沿(英文)》 2017年 第4卷 第4期 页码 418-427 doi: 10.15302/J-FEM-2017044
关键词: train rescheduling backup train metro line disruption timetable
Omnichannel retail operations with ship-to-store and ship-from-store options under supply disruption
《工程管理前沿(英文)》 页码 158-170 doi: 10.1007/s42524-022-0238-9
关键词: supply chain disruption omnichannel fulfillment option ship-from-store ship-to-store
山奈酚作为新型ADAM10抑制剂治疗金黄色葡萄球菌感染 Article
王婷婷, 王建锋, 许湘竹, 蒋帆, 吕红发, 齐清辉, 张灿, 吕强华, 邓旭明
《工程(英文)》 2023年 第28卷 第9期 页码 206-221 doi: 10.1016/j.eng.2023.03.006
宿主靶向疗法(HDT)是近年来兴起一种的治疗多重耐药金黄色葡萄球菌(S. aureus,简称“金葡菌”)感染的新策略。去整合素和金属蛋白酶10(ADAM10)作为α-毒素(Hla)不可或缺的特异性细胞受体,可通过多种机制促进金葡菌感染。ADAM10在致病机制中发挥的关键作用使其成为基于HDT治疗金葡菌感染的有力靶点。本研究首次证明ADAM10在金葡菌诱导的坏死性调亡中也发挥重要作用,这一发现拓宽了人们对ADAM10在金葡菌感染中作用的认识。通过荧光底物分解试验,我们进一步筛选出了一种强效ADAM10抑制剂——山奈酚,该化合物可抑制Hla引起的屏障破坏和细胞坏死性调亡,有效保护小鼠免受金葡菌感染。总的来说,本研究提出了一种新的宿主靶向治疗策略,并提供了有较高应用前景的候选化合物山奈酚。
标题 作者 时间 类型 操作
Two-stage stochastic programming with robust constraints for the logistics network post-disruption response
期刊论文
Evaluation of endocrine disruption and dioxin-like effects of organic extracts from sewage sludge in
LIU Cao,XU Yiping,MA Mei,HUANG Bingbin,WU Jingdong,MENG Qingyi,WANG Zijian,GEARHEART Robert Alan
期刊论文
Simultaneous harvesting and cell disruption of microalgae using ozone bubbles: optimization and characterization
Wan N. A. Kadir, Man K. Lam, Yoshimitsu Uemura, Jun W. Lim, Peck L. Kiew, Steven Lim, Siti S. Rosli, Chung Y. Wong, Pau L. Show, Keat T. Lee
期刊论文
Metro train rescheduling by adding backup trains under disrupted scenarios
Jiateng YIN, Yihui WANG, Tao TANG, Jing XUN, Shuai SU
期刊论文
Omnichannel retail operations with ship-to-store and ship-from-store options under supply disruption
期刊论文