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Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

《能源前沿（英文）》 2016年第10卷第1期页码 37-45 doi: 10.1007/s11708-015-0390-6

摘要： Compared with the traditional engines, the thermo-acoustic engines are relatively new and can act as the linear compressors for refrigerators. Many institutes have shown great interest in this kind of machine for its absence of moving mechanical part. In this paper, the influence of the dimensions of the main parts of the small-scale Stirling thermo-acoustic engine was numerically simulated using a computer code called DeltaEC. The resonator and the resonator cavity were found to be the most convenient and effective in improving the performance of the engine. Based on the numerical simulation, a small-scale Stirling thermo-acoustic engine were constructed and experimentally investigated. Currently, with a resonator length of only 1 m, the working frequency of the engine was decreased to 90 Hz and the onset temperature difference was decreased to 198.2 K.

关键词： thermo-acoustic Stirling engine small-scale simulation experiment

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Comprehensive comparison of small-scale natural gas liquefaction processes using brazed plate heat exchangers

Jitan WU, Yonglin JU

《能源前沿（英文）》 2020年第14卷第4期页码 683-698 doi: 10.1007/s11708-020-0705-0

摘要： The brazed plate heat exchanger (BPHE) has some advantages over the plate-fin heat exchanger (PFHE) when used in natural gas liquefaction processes, such as the convenient installation and transportation, as well as the high tolerance of carbon dioxide (CO ) impurities. However, the BPHEs with only two channels cannot be applied directly in the conventional liquefaction processes which are designed for multi-stream heat exchangers. Therefore, the liquefaction processes using BPHEs are different from the conventional PFHE processes. In this paper, four different liquefaction processes using BPHEs are optimized and comprehensively compared under respective optimal conditions. The processes are compared with respect to energy consumption, economic performance, and robustness. The genetic algorithm (GA) is applied as the optimization method and the total revenue requirement (TRR) method is adopted in the economic analysis. The results show that the modified single mixed refrigerant (MSMR) process with part of the refrigerant flowing back to the compressor at low temperatures has the lowest specific energy consumption but the worst robustness of the four processes. The MSMR with fully utilization of cold capacity of the refrigerant shows a satisfying robustness and the best economic performance. The research in this paper is helpful for the application of BPHEs in natural gas liquefaction processes.

关键词： liquefied natural gas brazed plate heat exchanger energy consumption economic performance robustness

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新疆煤田火区现状调查研究——小尺度区域热辐射信息分析

钟茂华,符泰然,胡忠斌

《中国工程科学》 2010年第12卷第1期页码 12-17

摘要：

开展煤田火区现状调查，研究其对区域气候变化、生态响应系统的影响是评估自然灾害研究中的重要方面。选择新疆部分煤田火区进行了实地考察，开展了小尺度区域热辐射信息分析，依据现场实测资料分析，给出煤田热隐患状态的适度评定。分析结果表明：小尺度区域热辐射测量方法可用于判别已灭煤田火区的灭火效果分析及新形成火区探测；对于正在燃烧的煤田火区可判断火区的范围并为灭火提供参考依据。

关键词：煤田火区热辐射信息温度小尺度热像仪

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A small-scale silica gel-water adsorption system for domestic air conditioning and water heating by the

Y. YU, Q. W. PAN, L. W. WANG

《能源前沿（英文）》 2020年第14卷第2期页码 328-336 doi: 10.1007/s11708-019-0623-1

摘要： A small-scale silica gel-water adsorption system with modular adsorber, which utilizes solar energy to achieve the cogeneration of domestic air conditioning and water heating effect, is proposed and investigated in this paper. A heat recovery process between two adsorbers and a mass recovery process between two evaporators are adopted to improve the overall cooling and heating performance. First, the adsorption system is tested under different modes (different mass recovery, heat recovery, and cogeneration time) to determine the optimal operating conditions. Then, the cogeneration performance of domestic cooling and water heating effect is studied at different heat transfer fluid temperatures. The results show that the optimal time for cogeneration, mass recovery, and heat recovery are 600 s, 40 s, and 40 s, respectively. When the inlet temperature of hot water is around 85°C, the largest cooling power and heating power are 8.25 kW and 21.94 kW, respectively. Under the condition of cooling water temperature of 35°C, the obtained maximum COP , COP , and SCP of the system are 0.59, 1.39, and 184.5 W/kg, respectively.

关键词： silica gel-water heat and mass recovery solar energy domestic cooling and heating

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小尺寸实验烟气浓度分布的影响因素

黄锐,杨立中,冯文兴,方廷勇,范维澄

《中国工程科学》 2003年第5卷第8期页码 54-58

摘要：

通过多组小尺寸实验多点离散测量烟气成分，对有限的实验数据做Lagrange插值分析，得到相同时刻烟气浓度在不同位置的变化规律以及烟气浓度场随时间的分布。考虑燃烧实验存在随机因素影响，提出用某一组分的质量分数相对值来比较不同实验数据所体现的规律，结果表明烟气浓度沿通道的一维分布受可燃物质量与流通开口高度影响较大。

关键词：烟气二维插值多点测量

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微小型机器鼠仿鼠行为学习与生成

高子航, 贾广禄, 谢宏钊, 黄强, 福田敏男, 石青

《工程（英文）》 2022年第17卷第10期页码 232-243 doi: 10.1016/j.eng.2022.05.012

摘要：

现有的仿生机器鼠仅可以执行一些基本的仿鼠运动基元（MP），并通过这些基元的刚性组合来形成简单的行为。为了模拟具有高相似性的典型实验鼠行为，本文提出使用概率模型和运动特征对实验鼠的行为进行参数化。首先，对15 个10 min 的实验鼠运动视频片段的分析表明，一只实验鼠在野外通常有6 种典型的行为，且每种行为都包含8 个运动基元的不同组合。本文首先使用softmax 分类器来获得实验鼠的行为-运动分层概率模型。其次，使用静态和动态的运动参数对运动基元组合进行特征化。本文分别使用分层聚类和模糊C均值（FCM）聚类获得静态和动态运动参数的优势值。这些优势值通过二阶傅里叶级数对实验鼠的脊柱关节轨迹进行拟合，并且通过具有两个隐藏层的反向传播（BP）神经网络对关节轨迹进行泛化。最后，将分层概率模型和泛化的关节轨迹分别作为控制策略和指令映射到机器鼠。本文在机器鼠上实现了6 种典型的仿鼠行为，其结果与实验鼠的行为相比显示出高度相似性。

关键词：仿生学微小型机器鼠神经网络学习行为生成

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Interference coordination in full-duplex HetNet with large-scale antenna arrays Article

Zhao-yang ZHANG, Wei LYU

《信息与电子工程前沿（英文）》 2017年第18卷第6期页码 830-840 doi: 10.1631/FITEE.1700047

摘要：对于未来的第五代通信系统，干扰协调已经成为最具挑战性的问题，而大规模多输入多输出、小蜂窝和全双工技术均是在此背景下充满前景的技术。提出一个针对两层异构网络的干扰协调框架，该异构网络包含了一个装备大规模天线阵列的宏蜂窝基站和大量使用全双工技术的小蜂窝基站。因为带内全双工和带外全双工会产生不同的干扰模式，为了抑制干扰和最大化网络吞吐量，每个小蜂窝基站在无线回程链路的全双工模式都应慎重选择。为解决此模式选择问题，提出两种集中式算法，分别是遗传算法和贪心算法。此外，为了更充分降低宏蜂窝基站的计算开销，进一步提出一种基于代价的分布式图染色算法。仿真结果表明：提出的算法显著提高了系统吞吐量。

关键词：大规模多输入多输出；全双工；小蜂窝；无线回程链路；分布式算法

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Concurrent fatigue crack growth simulation using extended finite element method

Zizi LU, Yongming LIU,

《结构与土木工程前沿（英文）》 2010年第4卷第3期页码 339-347 doi: 10.1007/s11709-010-0078-2

摘要： In this paper, a concurrent simulation framework for fatigue crack growth analysis is proposed using a novel small time scale model for fatigue mechanism analysis and the extended finite element method (X-FEM) for fatigue crack growth simulation. The proposed small time scale fatigue model does not require the cycle counting as those using the classical fatigue analysis methods and can be performed concurrently with structural/mechanical analysis. The X-FEM greatly facilitates crack growth simulation without remeshing requirements ahead of the crack tip as in the classical finite element method. The basic concept and theory of X-FEM was briefly introduced and numerical predictions of stress intensity factors are verified with reference solutions under both uniaxial and multiaxial loadings. The small time scale fatigue model is integrated into the numerical simulation algorithm for concurrent fatigue crack growth analysis. Model predictions are compared with available experimental observations for model validation.

关键词： small time scale model extended finite element method (X-FEM) crack growth multiaxial

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岩浆镍铜铂族矿床成矿过程中流体的作用——对小岩体超大型矿床的启示

张铭杰,汤庆艳,李文渊、余明、胡沛青、李建平

《中国工程科学》 2015年第17卷第2期页码 40-49

摘要：

超大型岩浆镍、铂族元素（PGE）硫化物矿床控制了Ni-PGE的资源量，本文根据地幔岩浆事件中Ni、Cu和PGE等在部分熔融、岩浆结晶和硫化物熔离过程的行为，讨论了岩浆Ni-Cu-PGE硫化物矿床的成矿岩浆类型与规模、成矿金属元素聚集的方式、岩浆演化过程中硫饱和度与硫化物液相不混溶的控制因素，探讨了流体对成矿金属的运移聚集作用等。认为地幔大规模的高度部分熔融（即要求高Mg岩浆）促使地幔硫化物及橄榄石中巨量的Ni和PGE进入岩浆，硫化物熔离富集成矿金属形成大型层状（或通道）岩体赋存的超大型Ni-Cu-PGE硫化物矿床；地幔超临界流体可能大范围内搬运聚集大量Ni-PGE金属元素，对岩浆硫化物矿床成矿可能有重要贡献，是小规模岩浆（小岩体）成矿的可能机制。

关键词：流体；小岩体；成矿作用

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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

null

《医学前沿（英文）》 2015年第9卷第1期页码 108-111 doi: 10.1007/s11684-014-0344-0

摘要：

Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.

关键词： gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib

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Discovery of small molecule degraders for modulating cell cycle

《医学前沿（英文）》页码 823-854 doi: 10.1007/s11684-023-1027-5

摘要： The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

关键词： PROTAC molecular glue degrader cell cycle CDK cyclin

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

《医学前沿（英文）》 2022年第16卷第3期页码 339-357 doi: 10.1007/s11684-022-0926-1

摘要： During mitosis, the allocation of genetic material concurs with organelle transformation and distribution. The coordination of genetic material inheritance with organelle dynamics directs accurate mitotic progression, cell fate determination, and organismal homeostasis. Small GTPases belonging to the Ras superfamily regulate various cell organelles during division. Being the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associated with cell organelle disruption in neoplastic and non-neoplastic diseases, such as cancer and Alzheimer’s disease. Recent discoveries shed light on the molecular properties of small GTPases as sophisticated modulators of a remarkably complex and perfect adaptors for rapid structure reformation. This review collects current knowledge on small GTPases in the regulation of cell organelles during mitosis and highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics during mitosis.

关键词： small GTPase cell organelle mitosis

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Gut microbiota and its implications in small bowel transplantation

null

《医学前沿（英文）》 2018年第12卷第3期页码 239-248 doi: 10.1007/s11684-018-0617-0

摘要：

The gut microbiota is mainly composed of a diverse population of commensal bacterial species and plays a pivotal role in the maintenance of intestinal homeostasis, immune modulation and metabolism. The influence of the gut microbiota on solid organ transplantation has recently been recognized. In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation (SBT) is closely associated with the alterations in microbial patterns in the gut. In this review, we focused on the recent findings regarding alterations in the microbiota following SBT and the potential roles of these alterations in the development of acute and chronic allograft rejection. We also reviewed important advances with respect to the interplays between the microbiota and host immune systems in SBT. Furthermore, we explored the potential of the gut microbiota as a microbial marker and/or therapeutic target for the predication and intervention of allograft rejection and chronic dysfunction. Given that current research on the gut microbiota has become increasingly sophisticated and comprehensive, large cohort studies employing metagenomic analysis and multivariate linkage should be designed for the characterization of host–microbe interaction and causality between microbiota alterations and clinical outcomes in SBT. The findings are expected to provide valuable insights into the role of gut microbiota in the development of allograft rejection and other transplant-related complications and introduce novel therapeutic targets and treatment approaches in clinical practice.

关键词： gut microbiota small bowel transplantation acute rejection chronic rejection mucosal immunity biomarker microbiota-targeted therapy

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

null

《医学前沿（英文）》 2013年第7卷第2期页码 157-171 doi: 10.1007/s11684-013-0272-4

摘要：

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.

关键词： non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling

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Performance prediction of switched reluctance generator with time average and small signal models

Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM

《能源前沿（英文）》 2013年第7卷第1期页码 56-68 doi: 10.1007/s11708-012-0216-8

摘要： This paper presents the complete mathematical model and predicts the performance of switched reluctance generator with time average and small signal models. The complete mathematical model is developed in three stages. First, a switching model is developed based on quasi-linear inductance profile. Next, based on the switching behaviour, a time average model is obtained to measure the difference between the excitation and generation time in each switching cycle. Finally, to track control voltage and current wave shapes, a small signal model is designed. The effectiveness of the complete multilevel model combining electrical machine, power converter, load and control with programming language is demonstrated through simulations. A PI controller is used for controlling the voltage of the generator. The results presented show that the controller exhibits accurate tracking control of load voltage under different operating conditions. This demonstrates that the proposed model is able to perform an accurate control of the generated output voltage even in transient situations. The simulation is performed to choose the control parameters and study the performance of switched reluctance generator prior to its actual implementation. Initial experimental results are presented using NI-Data acquisition card to control the output power according to load requirements.

关键词： generator reluctance switching model small signal model time average model