2023, Volume 20, Issue 1
Engineering >> 2023, Volume 20, Issue 1 doi: 10.1016/j.eng.2022.05.013
Physical Activity, Sedentary Behavior, and the Risk of Cardiovascular Disease in Type 2 Diabetes Mellitus Patients: The MIDiab Study
a Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China
b Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
c Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
d Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, China
e Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, China
f Endocrinology Department, The Southwest Hospital of AMU, Chongqing 400038, China
g Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China
h Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China
i Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
j Department of Endocrinology, The First People’s Hospital of Yinchuan, Yinchuan 750001, China
k Department of Endocrinology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital (the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine), Nanjing 210046, China
l Department of Endocrinology and Metabolism & Institute of Endocrinology, the First Hospital of China Medical University, Shenyang 110000, China
m Department of Endocrinology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
n Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
o Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, China
p Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
q Department of Endocrinology and Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
r Division of Endocrinology, Department of Internal Medicine, Inner Mongolia Autonomous Region People’s Hospital, Hohhot 010017, China
s Department of Endocrinology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
t Department of Endocrinology & Beijing Institute of Geriatrics, National Health Commission, Beijing Hospital, Beijing 100000, China
u Division of Endocrinology, Department of Internal Medicine, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China
v National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100032, China
w Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China
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Abstract
The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) time with a history of cardiovascular disease (CVD) and multifactorial (i.e., blood pressure (BP), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), and glycated hemoglobin A1c (HbA1c)) control status among type 2 diabetes mellitus (T2DM) patients in China. A cross-sectional analysis of 9152 people with type 2 diabetes from the Multifactorial Intervention on Type 2 Diabetes (MIDiab) study was performed. Patients were grouped according to their self-reported MVPA time (low, < 150 min·week−1; moderate, 150 to < 450 min·week−1; high, ≥ 450 min·week−1) and SED time (low, < 4 h·d–1; moderate, 4 to < 8 h·d–1; high, ≥ 8 h·d–1). Participants who self-reported a history of CVD were identified as having a CVD risk. Odds ratios (ORs) and 95% confidence intervals (95% CI) of CVD risk and multifactorial control status associated with MVPA time and SED time were estimated using mixed-effect logistic regression models, adjusting for China’s geographical region characteristics. The participants had a mean ± standard deviation (SD) age of (60.87 ± 8.44) years; 44.5% were women, and 25.1% had CVD. After adjustment for potential confounding factors, an inverse association between high MVPA time and CVD risk that was independent of SED time was found, whereas this association was not observed in the moderate-MVPA group. A higher MVPA time was more likely to have a positive effect on the control of BMI. Compared with the reference group (i.e., those with MVPA time ≥ 450 min·week−1 and SED time < 4 h·d–1), CVD risk was higher in the low-MVPA group: The OR associated with an SED time < 4 h·d–1 was 1.270 (95% CI, 1.040–1.553) and that associated with an SED time ≥ 8 h·d–1 was 1.499 (95% CI, 1.149–1.955). We found that a high MVPA time (i.e., ≥ 450 min·week−1) was associated with lower odds of CVD risk regardless of SED time among patients with T2DM.
Keywords
Type 2 diabetes ; Physical activity ; Sedentary time ; Cardiovascular disease
SupplementaryMaterials
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