Rett syndrome is a progressive neurodevelopmental disorder that lacks effective treatments. Although deep-brain stimulation can alleviate some symptoms in Rett model mice, this interventional manipulation requires deliberate surgical operations. Here, we report that electro-acupuncture stimulation (EAS) can ameliorate symptoms of an Mecp2-knockout rat model of Rett syndrome from the remote acupoints Baihui (GV 20), Yongquan (KI 1), and Shenmen (HT 7). We find that EAS not only prolongs the survival time of Rett rats, but also improves their behavior ability, including locomotion, motor coordination, and social interaction. Neural activation was observed in the substantia nigra of the midbrain, corpus striatum, and cerebral cortex of wild-type and Rett model rats, as reflected by the increased expression of the c-Fos protein. Hence, EAS provides a potential promising therapeutic tool for treating neurodevelopmental diseases.

Yanhong Sun ,   Zhifang Chen   et al.

Collaborative unmanned systems have emerged to meet our society’s wide-ranging grand challenges, with their advantages including high performance, efficiency, flexibility, and inherent resilience. Increasing levels of group/team autonomy have also been achieved due to the embodiment of artificial intelligence (AI). However, the current networked unmanned systems still do not have sufficient human-level intelligence and human needs fulfillment for the challenging missions in our lives. We propose in this paper a vision of human-centric networked unmanned systems: Unmanned Intelligent Clusters (UnIC). Within this vision, distributed unmanned systems and humans are connected via knowledge to achieve cognition. This paper details UnIC’s concept, sources of intelligence, and layered architecture, and review enabling technologies for achieving this vision. In addition to the technological aspects, the social acceptance is highlighted.

Fubiao Zhang ,   Jing Yu   et al.

This article reports the development of a novel switchable Pickering emulsion with rapid CO2/N2 responsiveness, which is stabilized using alumina nanoparticles hydrophobized in situ with a trace amount of a switchable superamphiphile via electrostatic interactions. With the introduction of CO2 for 30 s, the Pickering emulsion can be spontaneously demulsified with complete phase separation; the emulsion can then be reconstructed in response to N2 purging for 10 min followed by homogenization. Moreover, the stable Pickering emulsion can be stored for more than 60 days at room temperature without any visible change. The CO2/N2-responsive behavior of the switchable Pickering emulsion is attributed to the reversible desorption/adsorption of the switchable surfactants on the surfaces of the alumina nanoparticles upon the alternative bubbling of CO2 or N2. Thanks to the simple fabrication of the surfactant and the hydrophobization of the alumina nanoparticles, this research has developed an extremely facile and cost-efficient method for preparing a rapidly CO2/N2-responsive switchable Pickering emulsion. The dosage of the switchable surfactants has been significantly reduced by nearly 1500 times (from 150 to 0.1 mmol∙L−1) as compared with the dosage used in previous studies. Moreover, the as-prepared CO2/N2-responsive switchable Pickering emulsion is environmentally friendly, mild, and nontoxic; thus, it holds great potential for practical applications with considerable economic and environmental benefits, such as oil transport, fossil fuel production, environmental gases detection, and the encapsulation and release of active ingredients.

An Chen ,   Duo Wang   et al.


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