Resource Type

Journal Article 233

Conference Videos 1

Year

2024 11

2023 17

2022 23

2021 27

2020 16

2019 23

2018 14

2017 16

2016 14

2015 12

2014 8

2013 6

2012 4

2011 3

2010 7

2009 6

2008 6

2007 8

2006 2

2005 2

open ︾

Keywords

Antibiotic resistance genes 14

immunotherapy 8

immune checkpoint inhibitor 5

COVID-19 4

Antibiotic resistance genes (ARGs) 3

Advanced oxidation processes 2

Anti-inflammation 2

Antibiotic 2

Antibiotic resistance 2

Antibiotic resistant bacteria 2

Antibiotics 2

Drinking water distribution system 2

Epstein-Barr virus 2

Metagenome 2

Microbiota 2

Mobile genetic elements 2

PD-L1 2

Pathogen 2

Sulfonamide resistance genes 2

open ︾

Search scope:

排序： Display mode:

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsnon-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

HTML PDF Collect

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 896-908 doi: 10.1007/s11684-022-0944-z

Abstract: Results showed that FGF13 was lowly expressed in patients with AML and that its elevated expression was relatedmutation and functional analyses indicated that FGF13 was not associated with AML driver mutations but was relatedAs for immunity, FGF13 was remarkably associated with T cell count, immune checkpoint genes, and cytokinesOverall, FGF13 could serve as an independent prognostic factor for AML, and it was closely related to

Keywords： acute myeloid leukemia     FGF13     prognosis     immune-related genes     bone marrow niches    

HTML PDF Collect

Multi-target combinatory strategy to overcome tumor immune escape

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 208-215 doi: 10.1007/s11684-022-0922-5

Abstract: Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancerMany immune checkpoints were identified in the last decade since ipilimumab, which is the first immuneAlong with the characterization of more immune checkpoints, the combinatory treatment of multi-immunecheckpoints and their related inhibitors, and discusses the advantages of combination therapy, as wellas the risk of immune-related adverse events.

Keywords： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

HTML PDF Collect

Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 131-136 doi: 10.15302/J-FASE-2016096

Abstract: The accumulation of AsA, the expression patterns of the nine genes related to AsA metabolism as well1,4-lactone dehydrogenase, ascorbate peroxidase and monodehydro-ascorbate reductase are the crucial genes

Keywords： Chinese jujube     ascorbic acid     metabolism     gene     enzyme    

HTML PDF Collect

Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major

Jing Ma,Fei Liu,Xin Du,Duan Ma,Likuan Xiong

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 74-86 doi: 10.1007/s11684-017-0503-1

Abstract:

β-thalassemia is caused by β-globin gene mutations. However, heterogeneous phenotypes were found in individuals with same genotype, and still undescribed mechanism underlies such variation. We collected blood samples from 30 β-thalassemia major, 30 β-thalassemia minor patients, and 30 matched normal controls. Human lncRNA Array v2.0 (8 × 60 K, Arraystar) was used to detect changes in long non-coding RNAs (lncRNAs) and mRNAs in three samples each from β-thalassemia major, β-thalassemia minor, and control groups. Compared with normal controls, 1424 and 2045 lncRNAs were up- and downregulated, respectively, in β-thalassemia major patients, whereas 623 and 349 lncRNAs were up- and downregulated, respectively, in β-thalassemia minor patients. Compared with β-thalassemia minor group, 1367 and 2356 lncRNAs were up- and downregulated, respectively, in β-thalassemia major group. We selected five lncRNAs that displayed altered expressions (DQ583499, X-inactive specific transcript (Xist), lincRNA-TPM1, MRFS16P, and lincRNA-RUNX2-2) and confirmed their expression levels in all samples using real-time polymerase chain reaction. Based on coding-non-coding gene co-expression network and gene ontology biological process analyses, several signaling pathways were associated with three common organ systems exhibiting β-thalassemia phenotypes: hematologic, skeletal, and hepatic systems. This study implicates that abnormal expression levels of lncRNAs and mRNA in β-thalassemia cases may be correlated with its various clinical phenotypes.

Keywords： β-thalassemia     long non-coding RNA     mRNA     phenotypic heterogeneity     pathway    

HTML PDF Collect

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 883-895 doi: 10.1007/s11684-022-0919-0

Abstract: We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients throughimmunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis ofMoreover, we demonstrated that autophagy-related genes were activated by SEs and that the inhibition

Keywords： osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

HTML PDF Collect

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Frontiers of Medicine 2024, Volume 18, Issue 3,   Pages 430-445 doi: 10.1007/s11684-023-1049-z

Abstract: Crosstalk between cancer cells and the immune microenvironment is determinant for liver cancer progressionEmerging evidence demonstrates that the interaction between liver CSCs and immune cells plays a crucialThis review sheds light on the bidirectional crosstalk between liver CSCs and immune cells for liver

Keywords： liver cancer     cancer stem cell     immune cell     immunotherapy    

HTML PDF Collect

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1,   Pages 4-4 doi: 10.1007/s11783-021-1438-y

Abstract: Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs).However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system

Keywords： Antibiotic resistance genes     Metal resistance genes     Metagenomic analysis     Microplastics     Mariculture    

HTML PDF Collect

Occurrence and possible sources of antibiotic resistance genes in seawater of the South China Sea

Frontiers of Environmental Science & Engineering doi: 10.1007/s11783-024-1868-4

Abstract:

● The highest absolute abundance of ARGs in seawater reached 2.3 × 104 copies/mL.

Keywords： The South China Sea     Antibiotic resistance genes     Mobile genetic element     Source apportionment    

HTML PDF Collect

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

HTML PDF Collect

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 816-819 doi: 10.1007/s11684-020-0823-4

HTML PDF Collect

Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

HTML PDF Collect

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract: MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune

Keywords： molecular classification     precision medicine     pembrolizumab     PD-1/PD-L1     MSI-H    

HTML PDF Collect

The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis

Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing

Strategic Study of CAE 2014, Volume 16, Issue 5,   Pages 99-104

Abstract: miRNA databases such as miRanda，MirTarget2 and TargetScan are chosen to predict hsa- miR- 197 target genes；meanwhile，the intersection genes of these miRNA databases are chosen，and GO and Pathway analysis ofthese genes are carried out to explore the potential role of hsa-miR-197 playing in regulating the uterine

Keywords： uterine leiomyomas     hsa-miR-197     bioinformatics analysis     target genes    

HTML PDF Collect

Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline

Mengli Wang, Ruying Li, Qing Zhao

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1127-2

Abstract:

Sludge digestion is critical to control the spread of ARGs from wastewater to soil.

Fate of ARGs in three pretreatment-AD processes was investigated.

UP was more efficient for ARGs removal than AP and THP in pretreatment-AD process.

The total ARGs concentration showed significant correlation with 16S rRNA gene.

The bacteria carrying ARGs could be mainly affiliated with Proteobacteria.

Keywords： Tetracycline resistance genes     Sulfonamide resistance genes     16S rRNA gene     Sludge pretreatment     Anaerobic    

HTML PDF Collect

Title Author Date Type Operation

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches

Journal Article

Multi-target combinatory strategy to overcome tumor immune escape

Journal Article

Expression profiles of genes and enzymes related to ascorbic acid metabolism in fruits of

Yingying CHEN,Zhihui ZHAO,Jin ZHAO,Mengjun LIU

Journal Article

Changes in lncRNAs and related genes in β-thalassemia minor and β-thalassemia major

Jing Ma,Fei Liu,Xin Du,Duan Ma,Likuan Xiong

Journal Article

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

Journal Article

Cancer stem cell-immune cell crosstalk in the tumor microenvironment for liver cancer progression

Journal Article

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Journal Article

Occurrence and possible sources of antibiotic resistance genes in seawater of the South China Sea

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Persistence of humoral and cellular immune response after SARS-CoV-2 infection: opportunities and challenges

Tangchun Wu

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article

Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Journal Article

The expression mode of hsa-miR-197 in uterine leiomyomas tissue and related bioinformatics analysis

Xu Qing,Fu Ziyi,Wu Xiaoli,Huangfu Yushuang and Ling Jing

Journal Article

Distribution and removal of antibiotic resistance genes during anaerobic sludge digestion with alkaline

Mengli Wang, Ruying Li, Qing Zhao

Journal Article