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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.

Keywords： pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition cancer metastasis cancer stem cell

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Metformin for cancer prevention

Yonghua Yang

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 115-117 doi: 10.1007/s11684-011-0112-3

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.we tested the anticancer activity of orlistat, an FDA-approved anti-obesity drug, in human and mouse cancerand we found that orlistat, as a single agent, inhibited the proliferation and viabilities of lung cancerand other types of cancer.

Keywords： orlistat ferroptosis FAF2 lung cancer

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Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance

Fung Zhao, Eric W.-F. Lam

Frontiers of Medicine 2012, Volume 6, Issue 4, Pages 376-380 doi: 10.1007/s11684-012-0228-0

Abstract:

The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.

Keywords： FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1, Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding

Keywords： non-small cell lung cancer driver mutations treatment strategy resistant mechanism immune-checkpoint

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Low-dose CT for lung cancer screening: opportunities and challenges

Hongbing Shen

Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 116-121 doi: 10.1007/s11684-017-0600-1

Abstract:

Lung cancer is among the most frequently diagnosed cancers worldwide and the leading cause of cancerScreening for lung cancer coupled with earlier intervention has long been studied as an approach to mortalityOn the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populationsThis paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancerComplementary biomarkers and technical improvement are expected in the field of lung cancer screening

Keywords： lung cancer low-dose computerized tomography early detection opportunities challenges

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Developments in cancer prevention and treatment using traditional Chinese medicine

Hongsheng Lin, Jie Liu, Ying Zhang

Frontiers of Medicine 2011, Volume 5, Issue 2, Pages 127-133 doi: 10.1007/s11684-011-0137-7

Abstract: traditional Chinese medicine (TCM) and integrated medicine of oncology, we have made some achievements in cancerCurrently, TCM plays an indispensable role in cancer prevention and treatment.In the future, cancer treated with TCM will face unprecedented opportunities and challenges.This article reviews the developments of TCM in the treatment of cancer.

Keywords： traditional Chinese medicine (TCM) cancer

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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 387-411 doi: 10.1007/s11684-018-0646-8

Abstract: evidence has revealed the critical roles of TGF-β as a pro-tumorigenic factor in various types of cancerof TGF-β in lung and pancreatic cancers, in which TGF-β has been shown to be involved in cancer

Keywords： TGF-β EMT lung cancer pancreatic cancer latent form immune function GARP

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Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 323-332 doi: 10.1007/s11684-011-0172-4

Abstract:

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Lan Wang,Jueheng Wu,Jie Yuan,Xun Zhu,Hongmei Wu,Mengfeng Li

Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 41-51 doi: 10.1007/s11684-016-0429-z

Abstract: ubiquitin-conjugating E2 enzyme linked to tumor progression and a novel interacting partner of breast cancerHowever, the role of MID2 in breast cancer remains unknown.This study investigated the expression, prognostic value, and role of MID2 in breast cancer.The expression of MID2 mRNA and protein was significantly upregulated in breast cancer tissue and establishedThis study indicated that MID2 may be a novel prognostic marker and interventional target in breast cancer

Keywords： breast cancer MID2 proliferation overall survival xenograft

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomesequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy.The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing cancer genome whole genome sequencing exome transcriptome

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Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications

Aixiu Qiao,Feng Gu,Xiaojing Guo,Xinmin Zhang,Li Fu

Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 33-40 doi: 10.1007/s11684-016-0431-5

Abstract:

Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increasedPrevious studies focused on cancer cells, but an increasing number of recent studies have analyzed thecontribution of cancer microenvironment to the initiation and progression of breast cancer.Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various activealso serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer.

Keywords： cancer-associated fibroblast breast cancer progression prognosis

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Hydroxyl radical-involved cancer therapy via Fenton reactions

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3, Pages 345-363 doi: 10.1007/s11705-021-2077-3

Abstract: Therefore, supplying Fenton catalysts and elevating H₂O₂ levels into cancer cellsFurthermore, the challenges and future developments of hydroxyl radical-involved cancer therapy are discussed

Keywords： hydroxyl radical Fenton catalyst hydrogen peroxide cancer therapy