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2023 1

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ALDOB 1

cell proliferation 1

kidney cancer 1

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 503-517 doi: 10.1007/s11684-022-0947-9

Abstract: Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCCWe previously showed that ALDOB inhibited proliferation through a mechanism independent of its enzymaticWe showed that the corepressor C-terminal-binding protein 2 (CtBP2) is a novel ALDOB-interacting proteinFurthermore, ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2Mechanistically, our findings showed that ALDOB recruited acireductone dioxygenase 1, which catalyzes

Keywords： ALDOB     kidney cancer     cell proliferation    

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Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2

Journal Article