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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently underIn addition, BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitroIn the MC38 syngeneic model established in humanized OX40 knock-in mice, BGB-A445 demonstrated robustFurthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody.Taken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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BGB-A445, a novel non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation

Journal Article