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Journal Article 1

Year

2007 1

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BT325 1

Fibrillary 1

GFAP-Baxα 1

apoptotic 1

specificity 1

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Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 49-53 doi: 10.1007/s11684-007-0010-x

Abstract: We constructed a combined promoter 6HRE-GFAP (Hypoxia Responsive Element, Glial Fibrillary Acidic Proteinmicroenvironment in glioma and tested its efficacy and specificity in cultured cells, and then constructed GFAP-BaxαOur primary results showed that in U251 and BT325 cell lines, the activity of GFAP promoter was 16.40The activities of 6HRE-GFAP-promoter increased by 3.08 and 1.30-fold under 2% O condition compared withThe glioma cells showed typical apoptotic signs 90 hours after the transient transfection of GFAP-Baxα

Keywords： GFAP-Baxα     BT325     Fibrillary     apoptotic     specificity    

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Construction of 6HRE-GFAP-Baxα system specific for glioma gene therapy

TIAN Yongji, LI Guilin, GAO Jun, WANG Renzhi, KONG Yanguo, ZHANG Zhenxing, LI Shifang, TIAN Shiqiang, DOU Wanchen, ZHANG Bo

Journal Article