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IgA nephropathy 1

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antiproliferative activity 1

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building information modelling 1

cohesive zone model 1

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Toward deep impacts of BIM on education

Žiga TURK, Andreja ISTENIČ STARČIČ

Frontiers of Engineering Management 2020, Volume 7, Issue 1, Pages 81-88 doi: 10.1007/s42524-019-0035-2

Abstract: Building information models (BIM) provide a way to represent buildings and communicate about them. In teaching engineering, we also need representations of buildings and are communicating knowledge about them. While teaching engineering we refer to the very same real-world objects that have an explicit conceptualization in BIM. This explicit conceptualization did not exist in the age when design communication relied on drawings and documents. The question that this paper asks is this: due to BIM, communication in the industry has changed. Should communication of engineering knowledge – teaching – change as well and how? While much has been written about teaching BIM and incorporating BIM into the curricula, this paper is exploring the general impact of BIM on engineering education. It grounds earlier work (Turk, 2018) on insights from pedagogy. Five scenarios of the interplay between BIM-influenced engineering communication and teaching are presented. The paper argues that ignoring BIM may create a cognitive dissonance between academic learning and industrial work. We are finding that the impact of BIM is twofold: vertically there is a need to establish a reference between knowledge concepts (in teaching building) and information objects (in building information models). Horizontally BIM is an integration technology that allows for a more holistic design and planning. Both the language of individual courses as well as cross references and synergies among courses should change. A “T” style structure of the courses around BIM is proposed as a basis for integrated curriculum. Pedagogical approaches based on deep learning, model based learning and project based learning are suggested.

Keywords： engineering education building information modelling engineering communication curriculum development

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DQB1*060101 may contribute to susceptibility to immunoglobulin A nephropathy in southern Han Chinese

Wei Wang,Ming Li,Li Wang,Xueqing Yu

Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 507-516 doi: 10.1007/s11684-016-0475-6

Abstract:

Immunoglobulin A nephropathy (IgAN) is a common form of chronic glomerulonephritis with unknown pathogenesis. Accumulating evidences have shown the ethnic-specific association between certain human leukocyte antigen (HLA) alleles and IgAN susceptibility. This study was designed to explore the relationship between HLA-DQB1 alleles and disease susceptibility and clinical manifestations of patients with IgAN in southern Han Chinese. A PCR sequence-based typing technique was used to detect HLA-DQB1 alleles in 217 IgAN patients and 229 healthy subjects. Clinical data were collected from each patient at the time of renal biopsy. Twenty HLA-DQB1 alleles were detected in IgAN patients and healthy subjects. High frequency of HLA-DQB1*060101 and low frequency of HLA-DQB1*030101 were observed in IgAN patients compared with healthy controls. Further stratification analysis revealed that the frequency of DQB1*060101 was significantly higher in patients with urine protein≥1.0 g/24 h than in patients with urine protein<1.0 g/24 h. In combination with our previous DRB1 results, we also analyzed the association of DRB1-DQB1 haplotypes with IgAN. We found that the frequency of haplotype DRB1*090102-DQB1*060101 was significantly higher [odds ratio (OR) = 4.409, Pc = 0.016], whereas that of HLA-DRB1*070101-DQB1*020101 was significantly lower (OR= 0.194, Pc = 0.016) compared with healthy controls. Our study indicated that HLA-DQB1*060101 alleles may be a potential predictor of high-risk IgAN susceptibility in Chinese Han population.

Keywords： DQB1 human leukocyte antigen (HLA) IgA nephropathy haplotype association study

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Isogeometric cohesive zone model for thin shell delamination analysis based on Kirchhoff-Love shell model

Tran Quoc THAI, Timon RABCZUK, Xiaoying ZHUANG

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 2, Pages 267-279 doi: 10.1007/s11709-019-0567-x

Abstract: The isogeometric (IGA) thin shell model is based on Kirchhoff-Love theory.

Keywords： cohesive zone model IGA Kirchhoff-Love model thin shell analysis delamination

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer cell line

IGA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4, Pages 482-489 doi: 10.1007/s11705-013-1342-5

Abstract: In the last years, sugar beet pectins have been the subject of several investigations involving extraction methodologies, chemical composition and functional properties. The structure of pectins, which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancer cell lines like colon, prostate and breast. In this work, sugar beet pectin extraction was performed in the following steps: lipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatment with amyloglucosidase, protease, and pectinase. The enzymatic treatment was carried out with Rohapect DA6L under the following conditions: 50°C, pH 4.0, 2% enzyme/substrate (E/S) ratio, 15 h, and a solid to liquid ratio of 1 ∶ 10. The pectic extract showed a degree of polymerization (DP) profile of 55.8% with DP≥7; 4.9% with DP6; 5.8% between DP2 and DP6 ; 4.7% with DP2; and 28.8% with DP1. The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line. At a concentration range of 12.5–25 mg/mL the pectic extract killed 80.6% of the cells, exhibiting a higher antiproliferative activity than 4-hydroxytamoxifen (4-OHT), a classical anticancer drug, which killed 56.5% of the cells.

Keywords： pectic extracts antiproliferative activity breast cancer enzymatic treatment