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The FGF metabolic axis

Xiaokun Li

Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 511-530 doi: 10.1007/s11684-019-0711-y

Abstract: binding affinity for extracellular matrix heparan sulfate while acquiring affinity for transmembrane α-Klotho

Keywords： FGF19 FGF21 FGF23 FGFR metabolism endocrine Klotho

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1, Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.

Keywords： fibroblast growth factor 23 FGF receptor phosphate metabolism Klotho bone disease