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The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from

Sheng-Xuan LIU, Zhi-Hua HUANG

Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 342-345 doi: 10.1007/s11684-010-0099-1

Abstract: The aim of this study was to investigate the value of technetium etifenin injection ( Tc-EHIDA) hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis between infantile hepatitis syndrome and biliary atresia. Tc-EHIDA hepatobiliary scintigraphy in combination with duodenal fluid examination was used for evaluation in 84 infants with persistent infantile jaundice. For diagnosing biliary atresia, the sensitivity and specificity of scintigraphy were 100% and 74.5%, respectively; the sensitivity and specificity of scintigraphy in combination with duodenal fluid examination were 100% and 100%, respectively. In conclusion, hepatobiliary scintigraphy, which is a noninvasive, safe, valuable examination method, in combination with examination of duodenal fluid, is of value for the differential diagnosis between infantile hepatitis syndrome and biliary atresia.

Keywords： jaundice radionuclide hepatobiliary scintigraphy duodenal drainage

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A model of

Jingyu WANG,Hongwei FANG,Guojian HE,Lei HUANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 6, Pages 845-853 doi: 10.1007/s11783-014-0708-3

Abstract: The impact on the environment of radionuclide release from nuclear power plants has attracted increasedThis coefficient has significant effects on the distribution of radionuclide in seawater, suspended sediment

Keywords： distribution coefficient Daya Bay hydrodynamic sediment transport radionuclide transport

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Magnetotactic bacteria: Characteristics and environmental applications

Xinjie Wang, Yang Li, Jian Zhao, Hong Yao, Siqi Chu, Zimu Song, Zongxian He, Wen Zhang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1235-z

Abstract: • Magnetotactic bacteria (MTB) synthesize magnetic nanoparticle within magnetosomes. • The morphologic and phylogenetic diversity of MTB were summarized. • Isolation and mass cultivation of MTB deserve extensive research for applications. • MTB can remove heavy metals, radionuclides, and organic pollutants from wastewater. Magnetotactic bacteria (MTB) are a group of Gram-negative prokaryotes that respond to the geomagnetic ﬁeld. This unique property is attributed to the intracellular magnetosomes, which contains membrane-bound nanocrystals of magnetic iron minerals. This review summarizes the most recent advances in MTB, magnetosomes, and their potential applications especially the environmental pollutant control or remediation. The morphologic and phylogenetic diversity of MTB were first introduced, followed by a critical review of isolation and cultivation methods. Past research has devoted to optimize the factors, such as oxygen, carbon source, nitrogen source, nutrient broth, iron source, and mineral elements for the growth of MTB. Besides the applications of MTB in modern biological and medical fields, little attention was made on the environmental applications of MTB for wastewater treatment, which has been summarized in this review. For example, applications of MTB as adsorbents have resulted in a novel magnetic separation technology for removal of heavy metals or organic pollutants in wastewater. In addition, we summarized the current advance on pathogen removal and detection of endocrine disruptor which can inspire new insights toward sustainable engineering and practices. Finally, the new perspectives and possible directions for future studies are recommended, such as isolation of MTB, genetic modification of MTB for mass production and new environmental applications. The ultimate objective of this review is to promote the applications of MTB and magnetosomes in the environmental fields.

Keywords： Magnetotactic bacteria Magnetosome Heavy metal Radionuclide Organic pollutants

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Development Strategy for Innovation System of Radiopharmaceuticals in China

Peng Shuming, Yang Yuchuan, Yang Xia, Qian Dazhi, Zheng Gangyang, Zhao Xiangeng

Strategic Study of CAE 2022, Volume 24, Issue 6, Pages 116-126 doi: 10.15302/J-SSCAE-2022.06.010

Abstract:

Nuclear medicine plays an irreplaceable role in the diagnosis, therapy, and prognosis of various diseases. Radiopharmaceuticals are the cornerstone of nuclear medicine; their systematic development could accelerate the innovation and clinical application of radiopharmaceuticals to ensure people's health. In this study, we conducted in-depth research on the literature on the research direction of radiopharmaceuticals, visited over 10 domestic universities, institutes, hospitals, and enterprises related to nuclear medicine, and invited experts to conduct consultation, exchange, and industry discussion, to grasp the development trend and pattern of the research and application of radiopharmaceuticals in a relatively comprehensive way. Based on the analysis of the current status, technical level, and trend of radiopharmaceuticals in China and abroad, the development status of radiopharmaceuticals in China is summarized and the urgent problems faced are identified. This study introduces the contents that need to be focused on from two aspects: the technology research and development (R&D) system and the technology supervision system, and proposes key technological breakthroughs including the study on radiopharmaceutical targets and development of targeted structures; new radio-labelling; automatic, intelligent, and large-scale controllable preparation of radiopharmaceuticals; detection and evaluation of radiation dose of radiopharmaceuticals; and combined diagnosis and therapy of radiopharmaceuticals. The study suggests to (1) encourage the innovative development of interdisciplinary integration with a clinical orientation; (2) accelerate the construction of a technological innovation system for radiopharmaceuticals; and (3) strengthen the construction of a professional team for the R&D of radioactive drugs, so as to promote the overall improvement of nuclear medicine.

Keywords： nuclear medicine radiopharmaceuticals radiopharmaceutical evaluation targeted medicine radionuclide