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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2, Pages 130-136 doi: 10.15302/J-FASE-2014013

Abstract: Vacuolar protein sorting 36 (VPS36), a protein primarily known for its role in the Endosomal Sorting

Keywords： chicken Vps36 Ckap2 mRNA follicle

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Autophagy and the nutritional signaling pathway

Long HE,Shabnam ESLAMFAM,Xi MA,Defa LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3, Pages 222-230 doi: 10.15302/J-FASE-2016106

Abstract: During the initiation process, the ATG1/ULK1 (unc-51-like kinase 1) and VPS34 (which encodes a classmechanism of autophagy regulated by nutrient signaling especially for the two important complexes, ULK1 and VPS34

Keywords： Autophagy ULK1 complex VPS34 complex AMPK mTOR nutrient signaling

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A small-molecule pan-HER inhibitor alone or in combination with cisplatin exerts efficacy against nasopharyngeal carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 275-289 doi: 10.1007/s11684-022-0945-y

Abstract: nasopharyngeal carcinoma (NPC) and explored the anti-tumor effects of the novel pan-HER inhibitor HM781-36BHM781-36B inhibited NPC in vitro and in vivo.HM781-36B exerted synergistic effects with cisplatin on inhibiting proliferation and promoting apoptosisIn NPC xenograft models in nude mice, HM781-36B and cisplatin synergistically inhibited tumor growth.The pan-HER inhibitor HM781-36B alone or in combination with cisplatin represents promising therapeutic

Keywords： epidermal growth factor receptor ErbB receptors HM781-36B nasopharyngeal carcinoma molecular targeted