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Antibiotic adjuvant 1

Chelerythrine 1

Colistinmcr-1 1

Conjugation inhibitor 1

Dual effects 1

adjuvant treatment 1

adjuvant-induced arthritis 1

alum-stabilised emulsion 1

breast 1

cervical cancer 1

chemotherapy 1

concurrent chemoradiotherapy 1

hepatic resection 1

hepatocellular carcinoma 1

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metabolism 1

neo-adjuvant therapy 1

neoadjuvant therapy 1

neuroendocrine carcinoma 1

oleic to linoleic acid ratio 1

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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 112-116 doi: 10.1007/s11684-014-0345-z

Abstract: The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response

Keywords： neuroendocrine carcinoma     neo-adjuvant therapy     breast    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versusEligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery.adjuvant CCRT group.In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferiorAdjuvant chemotherapy alone is a favorable alternative post-operative treatment.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 155-169 doi: 10.1007/s11684-021-0848-3

Abstract: In this review, we evaluated the available evidence for the efficiency of adjuvant treatments to preventThe efficacy of molecular targeted drugs as an adjuvant therapy deserves further study.Adjuvant adoptive immunotherapy can significantly improve the clinical prognosis in the early stage.Adjuvant hepatic artery infusion chemotherapy might be beneficial in patients with vascular invasion.The efficiency of other adjuvant treatments needs to be further confirmed by large RCT studies.

Keywords： hepatocellular carcinoma     adjuvant treatment     hepatic resection     recurrence    

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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced

Keywords： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced    

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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 430-435 doi: 10.1007/s11684-010-0700-7

Abstract: This study aimed to investigate the effect of adjuvant therapy on the treatment of stage II pancreaticThe MST was 399 days for those with adjuvant therapy, 210 days for those without adjuvant therapy, 390The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of theIn the bypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improveThe proper adjuvant therapy can be suggested according to the general condition of the patients after

Keywords： pancreatic neoplasms     neoadjuvant therapy     survival    

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Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance Article

Huangwei Song,Xueyang Wang,Muchen Zhang,Zhiyu Zou,Siyuan Yang,Tian Yi,Jianfeng Wang,Dejun Liu,Yingbo Shen,Chongshan Dai,Zhihai Liu,Timothy R. Walsh,Jianzhong Shen,Congming Wu,Yang Wang,

Engineering 2024, Volume 32, Issue 1,   Pages 163-173 doi: 10.1016/j.eng.2023.06.012

Abstract:

The emergence and spread of the mobile colistin-resistance gene, mcr-1, and its variants pose a challenge to the use of colistin, a last-resort antibiotic used to treat severe infections caused by extensively drug-resistant (XDR) Gram-negative pathogens. Antibiotic adjuvants are a promising strategy to enhance the efficacy of colistin against colistin-resistant pathogens; however, few studies have considered the effects of adjuvants on limiting resistance-gene transmission. We found that chelerythrine (4 mg∙L−1) derived from Macleaya cordata extract, which is used as an animal feed additive, reduced the minimal inhibitory concentration (MIC) of colistin against an mcr-1 positive E. coli strain by 16-fold (from 2 to 0.125 mg∙L−1), eliminated approximately 104 colony-forming units (CFUs) of an mcr-1-carrying strain in a murine intestinal infection model, and inhibited the conjugation of an mcr-1-bearing plasmid in vitro (by >100-fold) and in a mouse model (by up to 5-fold). A detailed analysis revealed that chelerythrine binds to phospholipids on bacterial membranes and increases cytoplasmic membrane fluidity, thereby impairing respiration, disrupting proton motive force (PMF), generating reactive oxygen species (ROS), and decreasing intracellular adenosine triphosphate (ATP) levels, which subsequently downregulates mcr-1 and conjugation-associated genes. These dual effects of chelerythrine can expand the use of antibiotic adjuvants and may provide a new strategy for circumventing mobile colistin resistance.

Keywords： Chelerythrine     Antibiotic adjuvant     Conjugation inhibitor     Colistinmcr-1     Dual effects    

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Title Author Date Type Operation

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

Journal Article

Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Journal Article

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

Journal Article

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Journal Article

Dual Effects of Feed-Additive-Derived Chelerythrine in Combating Mobile Colistin Resistance

Huangwei Song,Xueyang Wang,Muchen Zhang,Zhiyu Zou,Siyuan Yang,Tian Yi,Jianfeng Wang,Dejun Liu,Yingbo Shen,Chongshan Dai,Zhihai Liu,Timothy R. Walsh,Jianzhong Shen,Congming Wu,Yang Wang,

Journal Article