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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 564-574 doi: 10.1007/s11684-018-0676-2

Abstract: modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced

Keywords： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced    

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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 112-116 doi: 10.1007/s11684-014-0345-z

Abstract: The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response

Keywords： neuroendocrine carcinoma     neo-adjuvant therapy     breast    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 93-104 doi: 10.1007/s11684-021-0892-z

Abstract: We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versusEligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery.adjuvant CCRT group.In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferiorAdjuvant chemotherapy alone is a favorable alternative post-operative treatment.

Keywords： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 155-169 doi: 10.1007/s11684-021-0848-3

Abstract: In this review, we evaluated the available evidence for the efficiency of adjuvant treatments to preventThe efficacy of molecular targeted drugs as an adjuvant therapy deserves further study.Adjuvant adoptive immunotherapy can significantly improve the clinical prognosis in the early stage.Adjuvant hepatic artery infusion chemotherapy might be beneficial in patients with vascular invasion.The efficiency of other adjuvant treatments needs to be further confirmed by large RCT studies.

Keywords： hepatocellular carcinoma     adjuvant treatment     hepatic resection     recurrence    

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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

Keywords： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 430-435 doi: 10.1007/s11684-010-0700-7

Abstract: This study aimed to investigate the effect of adjuvant therapy on the treatment of stage II pancreaticThe MST was 399 days for those with adjuvant therapy, 210 days for those without adjuvant therapy, 390The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of theIn the bypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improveThe proper adjuvant therapy can be suggested according to the general condition of the patients after

Keywords： pancreatic neoplasms     neoadjuvant therapy     survival    

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Treatment of gingival hyperplasia induced by cyclosporine A

MA Jingzhi, LI Ming, CAO Yingguang

Frontiers of Medicine 2008, Volume 2, Issue 3,   Pages 290-294 doi: 10.1007/s11684-008-0055-5

Abstract: The clinical therapy for cyclosporine A (CsA)-induced gingival hyperplasia (GH) and the pathologicalNine cases of CsA-induced GH after renal transplantation were subjected to periodontal non-surgical treatment

Keywords： post-transplantation     Gingival     cytoplasmic     CsA-induced     further    

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Influence of fluid-structure interaction on vortex induced vibration and lock-in phenomena in long span

Nazim Abdul NARIMAN

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 4,   Pages 363-384 doi: 10.1007/s11709-016-0353-y

Abstract: It was concluded that the two-way approach predicts earlier vortex induced vibration for lower critical

Keywords： vortex-induced vibration     fluid-structure interaction     Strouhal number     lock-in     kinetic energy    

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Formation of microporous polymeric membranes via thermally induced phase separation: A review

Min Liu,Shenghui Liu,Zhenliang Xu,Yongming Wei,Hu Yang

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 57-75 doi: 10.1007/s11705-016-1561-7

Abstract: A review of recent research related to microporous polymeric membranes formed via thermally induced phase

Keywords： polymer     microporous membrane     thermally induced phase separation    

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An overview of vortex-induced vibration (VIV) of bridge decks

Teng WU, Ahsan KAREEM

Frontiers of Structural and Civil Engineering 2012, Volume 6, Issue 4,   Pages 335-347 doi: 10.1007/s11709-012-0179-1

Abstract: A brief overview of vortex-induced vibration (VIV) of circular cylinders is first given as most of VIV

Keywords： vortex-induced vibration (VIV)     Volterra series     bridge    

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Synthesis and ultraviolet/aggregation-induced emission investigation of novel tetraphenylvinyl hydrazone

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 2061-2073 doi: 10.1007/s11705-023-2366-0

Abstract: sensors for better colorimetric responses, whereas the tetraphenyl unit is in charge of the aggregation-inducedAll the tetrahydrofuran/H2O solutions of the three compounds exhibit aggregation-induced emissionMoreover, good aggregation-induced emission effects are observed in the self-assembly of SC16

Keywords： organogelator     tetraphenylvinyldrazone     single crystal     aggregation-induced emission effect     ion sensing    

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Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

Frontiers of Medicine 2008, Volume 2, Issue 4,   Pages 370-373 doi: 10.1007/s11684-008-0071-5

Abstract: The data suggests that (1) an increase in neutrophil count is an evident feature of hyperoxia-inducedconcentration oxygen exposure can give rise to anorexia and malnutrition, which may play a role in hyperoxia-induced
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Effect of succinic acid deamidation-induced modification on wheat gluten

Lan LIAO, Mouming ZHAO, Haifeng ZHAO, Jiaoyan REN, Chun CUI, Xiao HU,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4,   Pages 386-392 doi: 10.1007/s11705-009-0250-1

Abstract: The effect of succinic acid deamidation-induced modification on wheat gluten was investigated in theMoreover, succinic acid deamidation-induced modification resulted in little change in molecular weight

Keywords： pH     isoelectric     conformation     deamidation-induced modification     molecular flexibility    

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Vortex-induced vibration of stay cable under profile velocity using CFD numerical simulation method

Wenli CHEN, Hui LI,

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 4,   Pages 357-363 doi: 10.1007/s11709-009-0060-z

Abstract: Vortex-induced vibration (VIV) of a stay cable subjected to a wind profile is numerically simulated through

Keywords： stay cable     fluid-structure interaction     numerical simulation     vortex-induced vibration    

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Numerical modeling of current-induced scour around multi-wall foundation using large-eddy simulation

Frontiers of Structural and Civil Engineering 2023, Volume 17, Issue 4,   Pages 546-565 doi: 10.1007/s11709-023-0943-4

Abstract: Scouring is one of the primary triggers of failure for bridges across rivers or seas. However, research concerning the scour mechanism of multi-wall foundations (MWFs) remains scarce, hindering the further application of MWFs. In this study, for the first time, the scouring effect caused by unidirectional flow around MWFs was examined numerically using FLOW-3D involving a large-eddy simulation. Initially, the applicability of the scouring model and input parameters was validated using a case study based on published measured data. Subsequently, the scouring effects of four MWFs with different wall arrangements and inflow angles, including the flow field analysis and scour pit and depth, were investigated thoroughly. It was found that the maximum scour depth of MWFs with an inflow angle of 0° was smaller than that of those with an inflow angle of 45°, regardless of the wall arrangement. Meanwhile, changing the inflow angle significantly affects the scour characteristics of MWFs arranged in parallel. In practical engineering, MWFs arranged in parallel are preferred considering the need for scouring resistance. However, a comparative analysis should be performed to consider comprehensively whether to adopt the form of a round wall arrangement when the inflow angle is not 0° or the inflow direction is changeable.

Keywords： multi-wall foundation     current-induced scour     bridge foundation     large-eddy simulation     numerical analysis    

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Title Author Date Type Operation

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

Journal Article

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

Xiaolong Wei,Chunfa Chen,Didi Xi,Jinwen Bai,Wenhe Huang,Luoxiang Rong,Mingyao Wu,Guojun Zhang

Journal Article

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

Journal Article

Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

Journal Article

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

Journal Article

Treatment of gingival hyperplasia induced by cyclosporine A

MA Jingzhi, LI Ming, CAO Yingguang

Journal Article

Influence of fluid-structure interaction on vortex induced vibration and lock-in phenomena in long span

Nazim Abdul NARIMAN

Journal Article

Formation of microporous polymeric membranes via thermally induced phase separation: A review

Min Liu,Shenghui Liu,Zhenliang Xu,Yongming Wei,Hu Yang

Journal Article

An overview of vortex-induced vibration (VIV) of bridge decks

Teng WU, Ahsan KAREEM

Journal Article

Synthesis and ultraviolet/aggregation-induced emission investigation of novel tetraphenylvinyl hydrazone

Journal Article

Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

Journal Article

Effect of succinic acid deamidation-induced modification on wheat gluten

Lan LIAO, Mouming ZHAO, Haifeng ZHAO, Jiaoyan REN, Chun CUI, Xiao HU,

Journal Article

Vortex-induced vibration of stay cable under profile velocity using CFD numerical simulation method

Wenli CHEN, Hui LI,

Journal Article

Numerical modeling of current-induced scour around multi-wall foundation using large-eddy simulation

Journal Article