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Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Frontiers of Medicine 2016, Volume 10, Issue 3, Pages 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tailextracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmicintegrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic
Keywords： integrin β3 signal transduction trans-dominant inhibition model
Treatment of gingival hyperplasia induced by cyclosporine A
MA Jingzhi, LI Ming, CAO Yingguang
Frontiers of Medicine 2008, Volume 2, Issue 3, Pages 290-294 doi: 10.1007/s11684-008-0055-5
Keywords： post-transplantation Gingival cytoplasmic CsA-induced further
Embryo-mediated genome editing for accelerated genetic improvement of livestock
Zachariah MCLEAN, Björn OBACK, Götz LAIBLE
Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2, Pages 148-160 doi: 10.15302/J-FASE-2019305
Selecting beneficial DNA variants is the main goal of animal breeding. However, this process is inherently inefficient because each animal only carries a fraction of all desirable variants. Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains. To realize rapid genetic gain, precise edits need to be introduced into genomically-selected embryos, which minimizes the genetic lag. However, embryo-mediated precision editing by homology-directed repair (HDR) mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos. This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos. It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism, enable multiplex editing and multiply rare elite genotypes. Such a breeding strategy would enable a more targeted, accelerated approach for livestock improvement that allows stacking of beneficial variants, even including novel traits from outside the breeding population, in the most recent elite genetic background, essentially within a single generation.
Keywords： animal breeding cattle cloning CRISPR/Cas9 cytoplasmic injection embryo genome editing germline chimaeras
Title Author Date Type Operation
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
Jiansong Huang,Yulan Zhou,Xiaoyu Su,Yuanjing Lyu,Lanlan Tao,Xiaofeng Shi,Ping Liu,Zhangbiao Long,Zheng Ruan,Bing Xiao,Wenda Xi,Quansheng Zhou,Jianhua Mao,Xiaodong Xi
Journal Article
Treatment of gingival hyperplasia induced by cyclosporine A
MA Jingzhi, LI Ming, CAO Yingguang
Journal Article
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