Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 1

Year

2014 1

Keywords

central composite design 1

curcuminoids 1

multi-component drug development 1

turmeric 1

Search scope:

排序： Display mode:

Development of a multi-component drug from turmeric using central composite design

Xiaohang ZHANG,Shengnan HAN,Yan LI,Jianlan JIANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3, Pages 362-368 doi: 10.1007/s11705-014-1439-5

Abstract: A methodology to develop multi-component drugs based on traditional Chinese medicines has been developed using central composite design. Several active components from the traditional Chinese medicine turmeric were chosen for use in a multi-component antitumor drug. Response surface methodology based on a central composite design was applied to determine the quantitative composition-activity relationships in order to optimize the amount of each component in the drug. An MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to measure the pharmacological activity as the response value. The experimental antitumor activity of the optimum combination was 92.85% in the MTT assay and superior to the activities of each single component. These results demonstrate that response surface methodology based on a central composite design is suitable for the design of multi-component drugs.

Keywords： multi-component drug development central composite design turmeric curcuminoids