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Crk-associated substrate, vascular smooth muscle and hypertension

TANG Dale

Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 323-331 doi: 10.1007/s11684-008-0062-6

Abstract: Crk-associated substrate (CAS), the first discovered member of the adapter protein CAS family, has been

Keywords： Contraction stimulation phosphatase-proline molecular structure discovered hypertension

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Growth responses of the newly-discovered Cd-hyperaccumulator Rorippa globosa and its accumulation characteristics

SUN Yuebing, ZHOU Qixing, WEI Shuhe, REN Liping

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 1, Pages 107-113 doi: 10.1007/s11783-007-0020-6

Abstract: has been identified as a newly-found Cd-hyperaccumulating species. In the present study, growth responses of and its accumulation characteristics of Cd and As were examined under joint stress of Cd and As. The results showed that Cd and As had an antagonistic effect on enhancing the growth of plants and Cd uptake and accumulation under the low concentration Cd and As treatments. When the concentration of Cd in the soil was 10 mg/kg and the concentration of As was 50 mg/kg, the highest growing height of the plant was up to 35.9 cm and the dry weight of the shoots was up to 2.2 g/pot, respectively. Meanwhile, the accumulation of Cd in the leaves under the joint stress was higher than that at the same level under single Cd pollution. However, there were synergic adverse effects on plant growth and Cd uptake under the combined pollution from a high concentration of Cd and As. Meanwhile, the accumulation of As in the roots was greater than that in the shoots, the translocation factor (TF) was "d0.3 and the bioaccumulation factor (BF) was "d0.6, thus showing that had an excluding effect on As uptake. These results confirmed that had a strong tolerant ability to the joint stress of Cd and As, and the potential for phytoremediation of soils contaminated by Cd and As.

Keywords： synergic adverse stress present study potential weight

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Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine Review

Jigang Wang, Chengchao Xu, Yin Kwan Wong, Yujie Li, Fulong Liao, Tingliang Jiang,Youyou Tu

Engineering 2019, Volume 5, Issue 1, Pages 32-39 doi: 10.1016/j.eng.2018.11.011

Abstract:

Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and understanding this remarkable phytochemical and its unique chemical and pharmacological properties. Today, even as artemisinin continues to serve as the foundation for antimalarial therapy, numerous challenges have surfaced in the continued application and development of this family of drugs. These challenges include the emergence of delayed treatment responses to artemisinins in malaria and efforts to apply artemisinins for non-malarial indications. Here, we provide an overview of the story of artemisinin in terms of its past, present, and future. In particular, we comment on the current understanding of the mechanism of action (MOA) of artemisinins, and emphasize the importance of relating mechanistic studies to therapeutic outcomes, both in malarial and non-malarial contexts.

Keywords： Artemisinin Mechanism of action Malaria Anti-cancer