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Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN,Chun WANG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 2, Pages 225-232 doi: 10.1007/s11705-014-1429-7

Abstract: Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

Keywords： controlled release drug delivery semi-solids polymer excipient