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Leonurine protects ischemia-induced brain injury via modulating SOD, MDA and GABA levels
Shilei ZHENG, Jingru ZHU, Jiao LI, Shuang ZHANG, Yunfei MA
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2, Pages 197-205 doi: 10.15302/J-FASE-2018245
The present study was designed to investigate the protective effects of leonurine, a compound purifiedWe found leonurine significantly improve the general activity of rats in an open-field test, which wasMoreover, serum SOD activity was significantly greater, MDA level lower in the leonurine group as comparedIn addition, GABA content in the cerebral cortex was significantly greater in high-dose leonurine groupand anti-excitotoxicity effects by targeting GABA and leonurine might become a useful adjuvant neuroprotective
Keywords: cerebral ischemia GABA neuroprotection leonurine SOD
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