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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy of rats with renovascular hypertension

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: pCon groups (with injection of the corresponding plasmid 4 mg/kg respectively into the tail vein), and valsartanThree weeks after drug administration, pAT1a-shRNA1, pAT1a-shRNA2 and valsartan respectively resultedThe carotid artery pressures of pAT1a-shRNA1, pAT1a-shRNA2 and valsartan groups were all significantlyratio of left ventricle weight to body weight (LV/BW) of the rats in pAT1a-shRNA1, pAT1a-shRNA2, and valsartanall < 0.01); however, there were no significant differences in expression levels of AT1 receptor in valsartan

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy of rats with renovascular hypertension

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article