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Akkermansia muciniphila 1

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Non-alcoholic fatty liver disease (NAFLD) 1

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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and a commonEmerging evidence indicates the therapeutic potential of A. muciniphila for NAFLD, especiallyHere, the current knowledge on the role of A. muciniphila in the progression of NAFLD was summarizedA. muciniphila abundancy is decreased in animals and humans with NAFLD.A. muciniphila presented benefits in preventing hepatic fat accumulation and inflammation in NAFLD

Keywords： Akkermansia muciniphila NAFLD NASH steatosis inflammation

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6, Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common metabolic diseases currently in theIn addition to the classical “Two-hit” theory, NAFLD has been recognized as a typical gut microbiota-relatedThe mechanisms underlying gut microbiota-mediated development of NAFLD include modulation of host energyAs a result, gut microbiota have been emerging as a novel therapeutic target for NAFLD by manipulatingrecent advances in gut microbiota-mediated mechanisms, as well as gut microbiota-targeted therapies on NAFLD

Keywords： gut microbiota NAFLD obesity insulin resistance bile acids probiotic

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An Update on the Efficacy and Functionality of Probiotics for the Treatment of Non-Alcoholic Fatty Liver Disease Article

Mingfei Yao, Lingling Qv, Yanmeng Lu, Baohong Wang, Björn Berglund, Lanjuan Li

Engineering 2021, Volume 7, Issue 5, Pages 679-686 doi: 10.1016/j.eng.2020.01.017

Abstract:

Non-alcoholic fatty liver disease (NAFLD), which has a global prevalence of 20%–33%, has becometreatment has been established so far, making it urgent to find effective strategies for the treatment of NAFLDWith the identification of the significant role played by the gut microbiota in the pathogenesis of NAFLD, studies on probiotics for the prevention and treatment of NAFLD are increasing in number.have also gained attention due to their potential as therapeutic options for the treatment of NAFLD

Keywords： Non-alcoholic fatty liver disease (NAFLD) Gut microbiota Probiotics Next-generation probiotics (NGPs