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cardiac fibrosis 1

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Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 387-411 doi: 10.1007/s11684-018-0646-8

Abstract:

Transforming growth factor (TGF)-β regulates a wide variety of cellular responses, includingAlthough tumor-suppressive roles of TGF-β have been extensively studied and well-characterized inmany cancers, especially at early stages, accumulating evidence has revealed the critical roles of TGFTGF-β is produced as latent high molecular weight complexes, and the latent TGF-β complex expressedInhibition of the TGF-β activities through regulation of the latent TGF-β complex activation

Keywords： TGF-β     EMT     lung cancer     pancreatic cancer     latent form     immune function     GARP    

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initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Frontiers of Medicine 2018, Volume 12, Issue 5,   Pages 559-565 doi: 10.1007/s11684-017-0562-3

Abstract: The FYVE protein SARA regulates the TGF-β signaling pathway by recruiting Smad2/3 and accelerating theirphosphorylation, thereby altering their susceptibility to TGF-β-mediated T cell suppression.Zfyve16 binds to Smad4 and their binding affects the formation of Smad2/3-Smad4 complex in TGF-β signalingThis finding is consistent with the role of Zfyve16 in facilitating TGF-β signaling.These results suggest that Zfyve16 inhibits the proliferation of T cells, possibly through the TGF-β

Keywords： Zfyve16     endofin     hematopoiesis     TGF-β     lymphocytes    

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Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGFIn isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 154-165 doi: 10.1007/s11684-008-0029-7

Abstract: 1 (TGF-?1) and collagen I (Col I) protein was detected by immunohistochemistry.The effect of soluble egg antigen (SEA) and PAE on the production of TGF-?The effect of TGF-?-SMA, TGF-?1 and Col I protein in the pre-treatment group.TGF-?1 could be secreted from PM?s stimulated by SEA. Meanwhile, the production of TGF-?1 from PM?

Keywords： cercariae     collagen     hyaluronic     OPMCM     soluble    

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Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 327-334 doi: 10.15302/J-FASE-2017163

Abstract: Longer porcine carcasses may be expected to have more vertebrae. Therefore, vertebrae number in pigs is an economically important trait. To examine the genetic basis of this trait, we genotyped 578 F Large White × Minzhu pigs using the Porcine SNP60K BeadChip. A genome-wide association study (GWAS) identified 36 significant single nucleotide polymorphisms (SNPs) on the chromosomes SSC1 (294.28–300.32 Mb) and SSC7 (102.22–109.39 Mb). A 6.04-Mb region that contained all 13 significant SNPs on SSC1 also contained the gene , previously reported to influence the number of vertebrae in pigs. However, the reported putative casual mutation of c.748C>T showed no genome-wide significant association with the trait, suggesting it was not a causal mutation in our population. The remaining 23 significant SNPs on SSC7 were concentrated in a 7.17-Mb region, which was within a quantitative trait locus interval for number of vertebrae. was the closest gene to the most significant SNP and might be a candidate. Haplotype sharing and block analysis refined the QTL to an interval of about 3 Mb containing 29 candidate genes. Of these 29 genes, the previously reported possible casual mutation of g.19034A>C was not found to be a causal mutation in our population. Exploration of these genes via additional genetic and functional studies in mammals revealed that could be a good candidate on SSC7. A mutation of c.1749G>A was detected by GWAS and could be proposed as a candidate causal mutation, or as closely linked to a causal mutation, for the number of vertebrae in pigs.

Keywords： genome-wide association study     number of vertebrae     pig     SSC7     TGFβ3    

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Title Author Date Type Operation

Intracellular and extracellular TGF-β signaling in cancer: some recent topics

Kohei Miyazono, Yoko Katsuno, Daizo Koinuma, Shogo Ehata, Masato Morikawa

Journal Article

initial activation by exosomal CD19 antigen but impair the function of CD19-specific CAR T-cells via TGF-β

Journal Article

Zfyve16 regulates the proliferation of B-lymphoid cells

Xuemei Zhao, Donghe Li, Qingsong Qiu, Bo Jiao, Ruihong Zhang, Ping Liu, Ruibao Ren

Journal Article

Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforming growth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice

CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang

Journal Article

Genome-wide search for candidate genes determining vertebrae number in pigs

Longchao ZHANG, Jingwei YUE, Xin LIU, Jing LIANG, Kebin ZHAO, Hua YAN, Na LI, Lei PU, Yuebo ZHANG, Huibi SHI, Ligang WANG, Lixian WANG

Journal Article