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The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 433-444 doi: 10.1007/s11684-013-0288-9

Abstract: When obesity occurs, the functions of adipose tissue may be deregulated, which is termed as adiposopathyAdiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseasesIn overweight or obese subjects with adiposopathy, hyperlipidemia exerts lipotoxicity in pancreatic isletWhen adiposopathy occurs, abnormal changes in the serum adipokine profile correlate with the developmentThe current paper briefly discusses the latest findings regarding the effects of adiposopathy-related

Keywords： obesity adiposopathy lipotoxicity adipokines diabetes