Search | Engineering

Subscribe Submit

Home Journals Focus Achievement Fronts About Us 中文版

Resource Type

Journal Article 2

Year

2016 1

2007 1

Keywords

Complex 1

control 1

function 1

nanomedicine 1

parenteral 1

poly(ethylene glycol) 1

poly(lactic acid) 1

production 1

reformulation 1

surgical 1

open ︾

Search scope:

排序： Display mode:

Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular

CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming

Frontiers of Medicine 2007, Volume 1, Issue 3, Pages 287-293 doi: 10.1007/s11684-007-0055-x

Abstract: The aim of this study was to explore the effects of parenteral nutrition (PN) with and without growth

Keywords： control function production surgical Complex

HTML PDF Collect

Polymeric micelle nanocarriers in cancer research

Dae Hwan Shin, Yu Tong Tam, Glen S. Kwon

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 3, Pages 348-359 doi: 10.1007/s11705-016-1582-2

Abstract: Amphiphilic block copolymers (ABCs) assemble into a spherical nanoscopic supramolecular core/shell nanostructure termed a polymeric micelle that has been widely researched as an injectable nanocarrier for poorly water-soluble anticancer agents. The aim of this review article is to update progress in the field of drug delivery towards clinical trials, highlighting advances in polymeric micelles used for drug solubilization, reduced off-target toxicity and tumor targeting by the enhanced permeability and retention (EPR) effect. Polymeric micelles vary in stability in blood and drug release rate, and accordingly play different but key roles in drug delivery. For intravenous (IV) infusion, polymeric micelles that disassemble in blood and rapidly release poorly water-soluble anticancer agent such as paclitaxel have been used for drug solubilization, safety and the distinct possibility of toxicity reduction relative to existing solubilizing agents, e.g., Cremophor EL. Stable polymeric micelles are long-circulating in blood and reduce distribution to non-target tissue, lowering off-target toxicity. Further, they participate in the EPR effect in murine tumor models. In summary, polymeric micelles act as injectable nanocarriers for poorly water-soluble anticancer agents, achieving reduced toxicity and targeting tumors by the EPR effect.

Keywords： nanomedicine parenteral poly(ethylene glycol) poly(lactic acid) reformulation