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Artemisia annua 1

anti-solvent crystallization 1

artemisinin 1

counter-current chromatography 1

flavonoid glycoside 1

high-speed counter-current 1

macroporous 1

quercetin 1

solubility 1

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Purification of artemisinin from quercetin by anti-solvent crystallization

Chandrakant R. MALWADE, Haiyan QU, Ben-Guang RONG, Lars P. CHRISTENSEN

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1, Pages 72-78 doi: 10.1007/s11705-013-1305-x

Abstract: The effect of an impurity (quercetin) on the performance of anti-solvent crystallization of artemisininThe solubility of quercetin was measured only in pure organic solvents at room temperature.from all four organic solvents and then the experiments were repeated with addition of an impurity (quercetinResults of the present work demonstrated that the presence of quercetin in the solution does not affectHowever, the purity of artemisinin crystals were reduced when quercetin concentration was 50% of its

Keywords： anti-solvent crystallization artemisinin quercetin solubility Artemisia annua

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chromatography coupled with high performance liquid chromatography for the separation and purification of Quercetin

Shengguo DENG, Zeyuan DENG, Yawei FAN, Jing LI, Rong LIU, Dongmei XIONG,

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 4, Pages 375-382 doi: 10.1007/s11705-009-0247-9

Abstract: Quercetin-3--sambubioside Quercetin-3--β-D-xylopyranosyl (1→2)-β-D-glucopyranoside wasQuercetin-3--sambubioside was a novel flavonoid glycoside from the leaves of , and its chemical structure

Keywords： two-phase-solvent flavonoid glycoside high-speed counter-current macroporous counter-current chromatography